IMMUNOHISTOCHEMISTRY IN DIAGNOSTICS OF COLORECTAL CANCER AND THE ROLE OF PROLIFERATION MARKER Ki-67
Introduction: the paper presents literature review devoted to the significance of biomarkers in colorectal cancer. Based on the analysis of data presented in evidence-based medicine databases, there is a lot of scientific information enabling appropriate solution of treatment modality.
Aim: to carry the systematic search of research papers dedicated to immunohistochemistry in colorectal cancer and to the significance of proliferation marker Ki67.
Materials and methods. To achieve the above described goal, we conducted a systematic literature search in evidence-based medicine electronic databases. The overall number of research papers identified was equal to 4342, of which 55 were included in the present review.
Results: the role of COX2, HER2, SMAD4, ALDH1 and Ki-67 in immunohistochemistry of colorectal cancer is studied to the various extent.
Conclusions: Ki67 expression indices in colorectal cancer still require further exploration, while available literature sources report controversial findings. It might prove to be useful to carry additional scientific research devoted to the establishment of correlation between Ki67 proliferation labeling, clinical and morphological characteristics of malignant tumor, and its prognostic meaning in colorectal cancer.
Kuantkhan T. Zhabagin, http://orcid.org/0000-0002-4304-5132
Yuliya M. Semenova, http://orcid.org/0000-0003-1324-7806
Marzhan A. Dauletyarova, http://orcid.org/0000-0001-8178-4051
Zukhra A. Manambaeva, http://orcid.org/0000-0001-9542-3222
Nurgul К. Zhumykbaeva, http://orcid.org/0000-0001-5627-4877
Nurlybek Keremkhanuly, http://orcid.org/0000-0002-9924-2856
Мukhtargazy Е. Tuleutaev, http://orcid.org/0000-0002-9237-2199
Кorkem S. Salykbaeva, http://orcid.org/0000-0003-3398-3595
Aleksandra A. Seliverstova, http://orcid.org/0000-0002-1677-0830
Zhanar N. Elemesova, http://orcid.org/0000-0003-3503-5097
Semey State Medical University, Semey city, Kazakhstan Republic
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6. Böger C., Behrens H.M., Röcken C. Ki67--An unsuitable marker of gastric cancer prognosis unmasks intratumoral heterogeneity // J Surg Oncol. 2016 Jan;113(1):46-54.
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16. Gissi D.B., Gabusi A., Tarsitano A., Badiali G., Marchetti C., Morandi L., Foschini M.P., Montebugnoli L. Ki67 Overexpression in mucosa distant from oral carcinoma: A poor prognostic factor in patients with long-term follow-up // J Craniomaxillofac Surg. 2016 Sep;44(9):1430-5.
17. Goossens-Beumer I.J., Zeestraten ECM, Benard A., Christen T., Reimers M.S., Keijzer R., et al. Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer. British journal of cancer. 2014;110(12): 2935–2944.
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11. de Azambuja E., Cardoso F., de Castro G. Jr., Colozza M, Mano M.S., Durbecq V., Sotiriou C., Larsimont D., Piccart-Gebhart M.J. Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients. Br J Cancer. 2007 May 21;96(10):1504-13.
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13. Dowsett M., Nielsen T.O., A'Hern R., Bartlett J., Coombes R.C., Cuzick J., Ellis M., Henry N.L., Hugh J.C., Lively T., McShane L., Paik S., Penault-Llorca F., Prudkin L., Regan M., Salter J., Sotiriou C., Smith I.E., Viale G., Zujewski J.A., Hayes D.F. Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group. J Natl Cancer Inst. 2011. Nov 16;103(22):1656-64.
14. Elzagheid A., Emaetig F., Alkikhia L., Buhmeida A., Syrjänen K., El-Faitori O., Latto M., Collan Y., Pyrhönen S. High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer. Anticancer Res. 2013 Aug;33(8):3137-43.
15. Fu H., Qi L., Chen L., He Y., Zhang N., Guo H. Expression of Ovol2 is related to epithelial characteristics and shows a favorable clinical outcome in hepatocellular carcinoma. Onco Targets Ther. 2016 Sep 29;9:5963-5973.
16. Gissi D.B., Gabusi A., Tarsitano A., Badiali G., Marchetti C., Morandi L., Foschini M.P., Montebugnoli L. Ki67 Overexpression in mucosa distant from oral carcinoma: A poor prognostic factor in patients with long-term follow-up. J Craniomaxillofac Surg. 2016 Sep;44(9):1430-5.
17. Goossens-Beumer I.J., Zeestraten ECM, Benard A., Christen T., Reimers M.S., Keijzer R., et al. Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer. British journal of cancer. 2014;110(12): 2935–2944.
18. Grossman H.B., Tangen C.M., Cordon-Cardo C., Cote R., Waldman F.M., De Vere White R.W., Karnad A.B., Glode M., Crawford E.D. Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: a Southwest Oncology Group Study. Oncol Rep. 2006 Oct;16(4):807-10.
19. Hayashi H., Beppu T., Sakamoto Y., Miyamoto Y., Yokoyama N., Higashi T., Nitta H., Hashimoto D., Chikamoto A., Baba H. Prognostic value of Ki-67 expression in conversion therapy for colorectal liver-limited metastases. Am J Cancer Res. 2015 Feb 15;5(3):1225-33.
20. He X., Chen Z., Jia M., Zhao X. Downregulated E-cadherin expression indicates worse prognosis in Asian patients with colorectal cancer: evidence from meta-analysis. PLoS One. 2013 Jul 29;8(7):e70858.
21. Hsi E.D., Jung S.H., Lai R., Johnson J.L., Cook J.R., Jones D, Devos S., Cheson B.D., Damon L.E., Said J. Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study. Leuk Lymphoma. 2008 Nov;49(11):2081-90.
22. Huang L., Ren F., Tang R., Feng Z., Chen G. Prognostic Value of Expression of Cyclin E in Gastrointestinal Cancer: ASystematic Review and Meta-Analysis. Technol Cancer Res Treat. 2016 Feb;15(1):12-9.
23. Kang W.K., Lee J.K., Oh S.T., Lee S.H., Jung C.K. Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse. BMC Gastroenterol. 2015 Jan 22;15:2.
24. Kántor O., Cserpán D., Völgyi B., Lukáts Á., Somogyvári Z. The Retinal TNAP. Subcell Biochem. 2015;76:107-23.
25. Kim H.S., Park S., Koo J.S., Kim S., Kim J.Y., Nam S., Park H.S., Kim S.I., Park B.W. Risk Factors Associated with Discordant Ki-67 Levels between Preoperative Biopsy and Postoperative Surgical Specimens in Breast Cancers. PLoS One. 2016 Mar 8;11(3):e0151054.
26. Kim N.K., Park J.K., Shin E., Kim Y.W. The combination of nuclear factor kappa B, cyclo-oxygenase-2 and vascular endothelial growth factor expression predicts poor prognosis in stage II and III colorectal cancer. Anticancer Res. 2014 Nov;34(11):6451-7.
27. Kunzmann A.T., Murray L.J., Cardwell C.R., McShane C.M, .McMenamin U.C, Cantwell M.M. PTGS2 (Cyclooxygenase-2) expression and survival among colorectal cancer patients: a systematic review. Cancer Epidemiol Biomarkers Prev. 2013 Sep;22(9):1490-7.
28. Liu Y., Yin W., Yan T., Du Y., Shao Z., Lu J. The clinical significance of Ki-67 as a marker of prognostic value and chemosensitivity prediction in hormone-receptor-positive breast cancer: a meta-analysis of the published literature. Curr Med Res Opin. 2013 Nov;29(11):1453-61.
29. Martins S.F., Amorim R., Mota S.C., Costa L., Pardal F., Rodrigues M., Longatto-Filho A. Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival. Biomed Res Int. 2015;2015:131685.
30. Melling N., Kowitz C.M., Simon R., Bokemeyer C., Terracciano L., Sauter G., Izbicki J.R., Marx A.H. High Ki67 expression is an independent good prognostic marker in colorectalcancer. J Clin Pathol. 2016 Mar;69(3):209-14.
31. Nowak K., Casey J., Chitale A., Kalchman I., Buss E., Keith S.W., Hegarty S.E., Curtis M., Solomides C., Shi W., Judy K.D., Andrews D.W., Farrell C.J., Werner-Wasik M. High KI67 Labeling Index in Resected WHO Grade 1 Meningiomas Correlates With a Higher Rate of Recurrence. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E572.
32. O'Dwyer D., Ralton L.D., O'Shea A., Murray G.I. The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. PloS one. 2011;6(11): e27718.
33. Ormenisan C., Kubik M., Legrand S., Kraemer D., Smotherman C., Masood S. The potential of ki67 and p53 assessment in development of individualized targeted therapy in breast cancer patients. Pathologica. 2015 Sep-Dec;107(3-4):177-80.
34. Pap Z., Ilyés I.Á., Mocan S.L., Dénes L., Muică Nagy-Bota M.C., Pávai Z., Szántó A. Changes in immunoexpression of p53, Ki-67, Ets-1, APAF-1 and PTEN in serrated and conventional colon adenomas. Rom J Morphol Embryol. 2015;56(4):1389-96.
35. Papagiorgis P.C. Segmental distribution of some common molecular markers for colorectal cancer(CRC): influencing factors and potential implications. Tumour Biol. 2016 May;37(5):5727-34.
36. Pascale M., Aversa C., Barbazza R., Marongiu B., Siracusano S., Stoffel F., Sulfaro S., Roggero E., Bonin S., Stanta G. The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients. Radiol Oncol. 2016 Jul 19;50(3):313-20.
37. Peng L., Zhou Y., Wang Y., Mou H., Zhao Q. Prognostic significance of COX-2 immunohistochemical expression in colorectal cancer: a meta-analysis of the literature. PLoS One. 2013;8(3):e58891.
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Жабагин К.Т., Семенова Ю.М., Даулетьярова М.А., Манамбаева З.А., Жумыкбаева Н.К., Керемханұлы Н., Тулеутаев М.Е., Салыкбаева К.С., Селиверстова А. А. Елемесова Ж.Н. Иммуногистохимические исследования в диагностике колоректального рака и роль маркера пролиферации Ki-67 / / Наука и Здравоохранение. 2016. № 5. С. 150-163. Zhabagin K.T., Semenova Yu.М., Dauletyarova М.А., Manambaeva Z.А., Zhumykbaeva N.К. Keremkhanuly N., Tuleutaev М.Е., Salykbaeva К.S., Seliverstova А.А., Elemesova Zh.N. Immunohistochemistry in diagnostics of colorectal cancer and the role of proliferation marker Ki-67. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 5, pp. 150-163. Жабагин К.Т., Семенова Ю.М., Даулетьярова М.А., Манамбаева З.А., Жумыкбаева Н.К., Керемханұлы Н., Тулеутаев М.Е., Салыкбаева К.С., Селиверстова А. А. Елемесова Ж.Н. Колоректальді ракты диагностикалаудағы иммуногистохимиялық тексерулер мен Ki-67 пролиферация маркерінің рөлі / / Ғылым және Денсаулық сақтау. 2016. № 5. Б. 150-163.Related publications:
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