EXPERIMENTAL STUDIES IN HEALTH SCIENCES
In this paper we present basic principles of planning and carrying out experimental studies in health sciences as well as analyzing the data collected in these studies. We present practical examples of sample size and group comparison using online calculators. Examples of experimental studies from international peer-reviewed literature are also presented. This article provides general introduction to experimental studies and does not substitute specialized literature in clinical epidemiology.
A.M. Grjibovski 1-4, S.V. Ivanov 5, M. A. Gorbatova 2
1 Department of International Public Health, Norwegian Institute of Public Health, Oslo, Norway;
2 Northern State Medical University, Arkhangelsk, Russia;
3 International Kazakh – Turkish University, Turkestan, Kazakhstan;
4 North-Eastern Federal University, Yakutsk, Russia;
5 North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia.
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13. Dell R. B., Holleran S., Ramakrishnan R. Sample size determination // ILAR journal. 2002. 43. P. 207-2013.
14. Fleiss J. L. Statistical Methods for Rates and Proportions. 2nd ed. New York: Wiley, 1981.
15. Fuchs C. S., Tomasek J., Yong C. J. et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial // Lancet. 2014. Vol. 383. P 31-39.
16. Hayashi C., Komazawa T., Hayashi F. A new statistical method to estimate the size of animal population // Ann. Inst. Stastist. Math. 1979. Vol. 31. P. 325-348.
17. Kilkenny C., Parsons N., Kadyszewski E. et al. Survey of the quality of experimental design, statistical analysis and reporting of research using animals // PLoS ONE. 2009. Vol. 4. P. 1-11.
18. Lautenschlager N. T., Cox K. L., Flicker L. et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease - a randomized trial // JAMA. 2008. Vol. 9. P. 1027-1-37.
19. Medical Research Council (1948). Streptomycin treatment of pulmonary tuberculosis: a Medical Research Council investigation // Br. Med. J. 1948. Vol. 2. P.769–782.
20. Snedecor G. W., Cochran W. G. Statistical Methods. 8th ed. Ames : Iowa State Press. 1989.
21. Yoon J. S., Sohn W., Lee O. Y. et al. Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial // J. Gastroenterol. Hepatol. 2014. Vol. 1. P. 52-59.
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Grjibovski A. M., Ivanov S. V., Gorbatova M. A. Experimental studies in health sciences. Nauka i Zdravoohranenie [Science & Healthcare]. 2015, 6, pp. 5-17.Related publications:
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