EPIDEMIOLOGY OF PROSTATE CANCER IN SEMEY REGION OF EAST KAZAKHSTAN REGION
Background: prostate cancer holds second position out of all cancer morbidity among the world male population. At the same time, taking into account the female population, incidence of prostate cancer is on the fourth place, yielding its position to lung cancer, breast cancer and colorectal cancer. Prostate cancer is most common in the developed world, for which long life expectancy is characteristic, but it is less common in Asian countries, where it locates in the sixth place after cancers of other localizations: lung, stomach, liver, colorectal cancer and esophageal cancer. Unfortunately, the available databases of scientific information contain very scare information about epidemiology of prostate cancer in the countries of Central Asia, which emphasizes the relevance of our study.
Aim: to assess the specific features of prostate cancer cases in patients followed by the Regional Oncology Hospital in Semey over the period of two years (2015-2016).
Materials and methods. The study had crossectional design. To achieve the goal, we conducted an analysis of official medical documentation, presented by 215 prostate cancer cases followed by the Regional Oncology Dispensary Semey city, East Kazakhstan Region for a period of 2 years (2015 to 2016). We revealed all reported cases of prostate cancer presented in the regional oncology hospital in the period from January 1, 2015 to December 31, 2016. The age-sex, ethnic and morphological features of prostate cancer were studied. The statistical processing of the results was carried out using the statistical package SPSS (Statistical Package for the Social Sciences) version 20.0 for Windows (the license of GMU Semey). Pearson’s chi-square was used when comparing two independent groups of nominal variables. Differences between groups were considered reliable if they had a 5% significance level (p <0.05)
Results: During the study period, 215 cases of prostate cancer were followed by the Regional Oncology Dispensary in Semey, of which 35 were fatal. The majority of patients (161 individuals – 74.9%) were in the age group of 60 to 79 years. By the ethnic origin, 47% (n = 101) were Kazakhs, 39% (n = 84) were Russians, while the rest were representatives of other national ethnic groups (14% – 30 patients). The majority of patients (46.5 – 100 individuals) were followed due to IIA stage of the disease, and 19.1% (n = 41) of patients were followed with IIB stage. Third cancer stage held the third position (34 patients – 15.8%).
Conclusions: Prostate cancer is a disease which is likely to become more important in the perspective of the next few years. This is facilitated both by the introduction of screening program and by the aging of country population with the adoption of habits and lifestyle typical of the population of the developed countries of the world. In this regard, it appears to be interesting to study the patterns of disease distribution in order to plan programs aimed at an early identification, timely treatment and rehabilitation.
Key words: prostate cancer, cancer stage, Semey region, cancer screening, PSA.
Erlan А. Ospanov 1, http://orcid.org/0000-0002-1344-5477
Тasbolat А. Аdylkhanov 1, http://orcid.org/0000-0002-9092-5060
Sholpan Е. Тоkanova 1, http://orcid.org/0000-0003-0304-4976
Yuliya М. Semenova 1, http://orcid.org/0000-0003-1324-7806
Marzhan А. Dauletyarova 1, http://orcid.org/0000-0001-8178-4051
Malcolm A. Moore 2,
Ashat A. Kabikenov 3, http://orcid.org/0000-0002-8644-2859
Erganat O. Sabekov 3, http://orcid.org/0000-0002-7934-8610
Daniar T. Raisov 1, http://orcid.org/0000-0002-3872-1263
1 Semey State Medical University, Semey, Republic of Kazakhstan;
2 Asia Pacific Organization for Cancer Prevention, Korean Cancer Center, Director-Coordination, Goyang, Korea;
3Semey Regional Oncology center, Semey, Republic of Kazakhstan
1. Гржибовский А.М., Иванов С.В. Поперечные (одномоментные) исследования в здравоохранении // Наука и Здравоохранение. 2015. № 2. С. 5-18.
2. Гржибовский А.М., Иванов С.В., Горбатова М.А. Описательная статистика с использованием пакетов статистических программ Statistica и SPSS // Наука и Здравоохранение. 2016. № 1. С. 7-23.
3. Ишкинин Е.И., Жылкайдарова А.Ж., Нургалиев Н.С., Ошибаева А.Е. Первые результаты скрининга рака предстательной железы. Вестник КазНМУ. 2016. №1. С.595-598
4. Суконко О.Г., Красный С.А., Океанов А.Е., Моисеев П.И., Поляков С.Л., Евмененко А.А., Тарендь Д.Т. Рак Предстательной Железы В Республике Беларусь: Вчера, Сегодня, Завтра. Здравоохранение (Минск). 2013. №11. С. 34-42
5. Чиссов В.И., Русаков И.Г. Заболеваемость раком предстательной железы в Российской Федерации. Экспериментальная и клиническая урология. 2011. №2-3. С.6-7
6. Anton-Culver H., Chang J., Bray F., Znaor A., Stevens L., Eser S., Silverman B., Nimri O., Pavlou P., Charalambous H., Demetriou A., Ward K., Ziogas A. Cancerburden in four countries of the Middle East Cancer Consortium (Cyprus; Jordan; Israel; Izmir (Turkey)) with comparison to the United States surveillance; epidemiology and end results program. Cancer Epidemiol. 2016 Oct;44:195-202
7. Barry M.J., Simmons L.H. Prevention of Prostate Cancer Morbidity and Mortality: Primary Prevention and EarlyDetection. Med Clin North Am. 2017 Jul;101(4):787-806
8. Bray F., Jemal A., Grey N et al. Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol, (2012). 13:790–801.
9. Bray F., Ren J.S., Masuyer E., Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer, (2013). 132:1133–1145.
10. Center M.M., Jemal A., Lortet-Tieulent J. et al. (2012). International variation in prostate cancer incidence and mortality rates. Eur Urol, 61:1079–1092
11. Chimed T., Sandagdorj T., Znaor A., Laversanne M., Tseveen B., Genden P., Bray F. Cancerincidence andcancercontrol in Mongolia: Results from the National Cancer Registry. 2008-12. Int J. Cancer. 2017. Jan 15;140(2):302-30
12. Cuzick J., Thorat M.A., Andriole G., Brawley O.W., Brown P.H., Culig Z., Eeles R.A., Ford L.G., et al. Prevention and early detection of prostate cancer. Lancet Oncol. 2014 Oct;15(11): e484-92
13. Ekanem I.O., Parkin D.M. Five yearcancerincidence in Calabar, Nigeria (2009-2013). Cancer Epidemiol. 2016 Jun;42:167-72
14. Ferlay J., Soerjomataram I., Ervik Metal. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base. 2013. No.11 [Internet]. Lyon: IARC. Доступно:http://globocan.iarc.fr
15. Forman D., Bray F., Brewster D.H. et al., eds. Cancer Incidence in Five Continents, Vol. X [electronic version].Lyon: IARC. 2013. Доступно: http://ci5.iarc.fr
16. Gasnier A., Parvizi N. Updates on thediagnosisand treatment ofprostate cancer. Br J Radiol. 2017. May 30:20170180
17. Geng E.H., Hunt P.W., Diero L.O. et al. Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009. 2011. J. Int AIDS Soc, 14:46
18. Global Initiative for Cancer Registry Development in Low- and Middle-Income Countries. Доступно:http://gicr.iarc.fr/
19. Global Burden of Disease Cancer Collaboration.Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2017. Apr 1;3(4):524-548
20. Global Burden of Disease Cancer Collaboration. The Global Burden of Cancer 2013. JAMA Oncol. 2015. Jul;1(4):505-27
21. Korir A., Okerosi N., Ronoh V., Mutuma G., Parkin M. Incidence of cancer in Nairobi, Kenya (2004-2008). Int J Cancer. 2015. Nov 1; 137(9):2053-9
22. Lee D.J., Mallin K., Graves A.J., Chang S.S., Penson D.F., Resnick M.J., Barocas D.A. Recent changes inprostate cancer screening practices andprostate cancerepidemiology. J Urol. 2017 May 25
23. Medhanie G.A., Fedewa S.A., Adissu H., DeSantis C.E., Siegel R.L., Jemal A. Cancerincidence profile insub-SaharanAfrican-born blacks in the United States: Similarities and differences with US-born non-Hispanic blacks. Cancer. 2017 Apr 13
24. Omran A.R. The epidemiologic transition. A theory of the epidemiology of population change. Milbank Mem Fund Q., 197149:509–538. 2307/3349375 PMID:5155251
25. Pan R., Zhu M., Yu C., Lv J., Guo Y., Bian Z., Yang L., Chen Y., Hu Z., Chen Z., Li L., Shen H. China Kadoorie Biobank Collaborative Group. CancerIncidence and Mortality: A Cohort Study in China, 2008-2013. Int J Cancer. 2017 Jun 8.
26. Pezaro C., Woo H.H., Davis I.D. Prostate cancer: measuring PSA. Intern Med J. 2014. May;44(5):433-40
27. Printz C. Early-stage prostate cancer, PSA screening rates decline. Cancer. 2016 Mar 15;122(6):825
28. Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J., Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar;65(2):87-108
29. WHO. Global Status Report on Non-Communicable Diseases 2010. Geneva: WHO. 2011. Доступ: http://www.who.int/nmh/publications/ncd_report2010/en/
30. WHO (). The top 10 causes of death. 2013. Доступно: http://www.who.int/mediacentre/factsheets/fs310/en/ (Дата обращения: 22 мая 2018 года)
31. WHO Mortality Database. Доступно: http://www.who.int/healthinfo/statistics/mortality_rawdata/en/index.html (Дата обращения: 22 мая 2018 года)
32. World Cancer Report. 2014. C. 17. http://publications.iarc.fr/Non-Series-Publications/World-Cancer-Reports (Дата обращения: 22 мая 2018 год)
Bibliography link
Библиографическая ссылка:
Оспанов Е.А., Адылханов Т.А., Токанова Ш.Е., Семенова Ю.М., Даулетьярова М.А., Мур M.A., Кабыкенов А.А., Сабеков Е.О., Раисов Д.Т. Эпидемиология рака предстательной железы в Семейском регионе Восточно-Казахстанской области / / Наука и Здравоохранение. 2018. 3 (Т.20). С. 32-44.
Ospanov E.А., Аdylkhanov Т.А., Тоkanova Sh.Е., Semenova Yu.М., Dauletyarova M.А., Moore M.A., Kabikenov A.A., Sabekov E.O., Raisov D.T. Epidemiology of prostate cancer in Semey region of East Kazakhstan region. Nauka i Zdravookhranenie [Science & Healthcare]. 2018, (Vol.20) 3, pp. 32-44.
Оспанов Е.А., Адылханов Т.А., Токанова Ш.Е., Семенова Ю.М., Даулетьярова М.А., Мур M.A., Кабыкенов А.А., Сабеков Е.О. Раисов Д.Т. Семей аймағы бойынша аталық без обырының эпидемилогиясы Шыгыс Қазақстан облысы / / Ғылым және Денсаулық сақтау. 2018. 3 (Т.20). Б. 32-44.