CASE-CONTROL STUDIES IN HEALTH SCIENCES

In this paper we present basic principles of planning and carrying out case-control studies in health sciences as well as analyzing the data collected in these studies. We present practical examples of sample size and effect measures calculation for matched and unmatched case-control studies using online calculators and Epi Info software. Examples of studies using case-control design from international peer-reviewed literature are also presented. This article provides general introduction to case-control studies and does not substitute specialized literature in clinical epidemiology.

A. M. Grjibovski1-3, S. V. Ivanov4, M. A. Gorbatova2

1 Norwegian Institute of Public Health, Oslo, Norway;

2 Northern State Medical University, Arkhangelsk, Russia;

3 International Kazakh – Turkish University, Turkestan, Kazakhstan;

4 North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia

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14.      Cleopas T.J. et al. Statistics Applied to Clinical Trials. 4th ed. Springer, 2009.
15.      Coureau G., Bouvier G., Lebailly P. et al. Mobile phone use and brain tumours in the CERENAT case-control study. Journal of Occupational and Environmental Medicine. 2014. Vol. 0. P. 1–9.
16.      Doll R., Hill R. Smoking and carcinoma of the lung. British Medical Journal, 1950. Sep. 30. P. 739-748.
17.      Jha P., Jacob B., Gajalakshmi V. et al. A nationally representative case-control study of smoking and death in India. New England Journal of Medicine. 2008. Vol. 11. P. 1137-1147.
18.      Kelsey J.L, Whittemore A.S., Evans A.S. et al. Methods in observational epidemiology. Oxford, Oxford University Press, 1996.
19.      Kieler H., Malm H., Artama M. et al. Use of antidepressants and association with elective termination of pregnancy: population based case-control study. International Journal of Obstetrics and Gynaecology. 2014. Nov 14. P. 1-7.
20.      Mann C. J. Observational research methods. Research design II: cohort, cross sectional, and case-control studies. Emergency Medical Journal. 2003. Vol 20. P. 54–60.
Vander Weele T. J. Sample Size and Power Calculations for Case-only Interaction Studies. Epidemiology. 2011. Vol. 6. P. 873-874
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Bibliography link

Grjibovski A. M., Ivanov S. V., Gorbatova M. A. Case-control studies in health sciences. Nauka i Zdravoohranenie [Science & Healthcare]. 2015, 4, pp. 5-17.


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