INTERRELATION OF INSULIN RESISTANCE AND POLYMORPHISMS OF GENES IN LIPID METABOLISM GENES AND RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. LITERATURE REVIEW
Introduction: Insulin resistance, dyslipidemia, abdominal obesity and arterial hypertension are risk factors, the combination of which is called metabolic syndrome, which increase the risk of developing cardiovascular disease and complications. The reason for the relationship of these risk factors is being studied and the role of gene polymorphisms in this plays not the last role.
The aim: A review of the literature on the molecular genetic basis for the development of insulin resistance in metabolic syndrome and arterial hypertension.
Materials and methods: Literature search was conducted in the databases PubMed (https://www.ncbi.nlm.nih.gov/pubmed/), Scopus (https://www.scopus.com/), Ebscohost (https://search.ebscohost.com/), Medline (https://www.nlm.nih.gov/), The Сocrane Library (http://www.cochranelibrary.com/), SpringerLink (https://link.springer.com/), Web of Knowledge (Thomson Reuters) (https://login.webofknowledge.com), Paragraph Medicine (https://prg.kz/medicine_info), ScienceDirect (https://www.sciencedirect.com/). The depth of the search was from 1998 to 2019. The inclusion criteria were: reports on randomized and cohort studies conducted on large populations; Meta-analyzes and systematic reviews; Articles in English, Russian. Criteria for exclusion were: articles describing single cases and a series of cases; Articles published earlier in 1998; Materials that do not have an evidence base, summaries of reports, abstracts and newspaper articles. Out of 98 literary sources, 56 english articles were selected as analytical material for this article.
Results: A review of the sources showed that even the presence of any polymorphism of a gene may not give a phenotypic trait, here gene-gene interactions may play a role that can influence the phenotypic manifestation of these genes.
Conclusions: A detailed and accurate study of this interesting and important hypothesis should be useful for determining the etiology of common complex diseases and may have a potential impact on the study of genes responsible for complex human diseases.
Aizhan Т. Shakhanova1, http://orcid.org/0000-0001-8214-8575
Nurlan E. Aukenov2, http://orcid.org/0000-0002-3163-2997
Alma U. Nurtazina3, http://orcid.org/0000-0002-9737-4003
Tungyshkhan E. Shakhanov4, http://orcid.org/0000-0002-8698-7541
Dana K. Kozhakhmetova5, http://orcid.org/0000-0002-8367-1461
1Department of Propaedeutics in internal diseases, NCJSC "Medical University of Semey", Semey, Republic of Kazakhstan;
2Department of Science and New Technologies of the Department of Science and Human Resources of the Ministry of Health of the Republic of Kazakhstan, Nur-Sultan, Republic of Kazakhstan;
3Department of Innovation in Science and Clinic, 4Department of Faculty Therapy, 5 Department of Propaedeutics in internal diseases, NCJSC "Medical University of Semey",
Semey City, Republic of Kazakhstan;
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Shakhanova A.Т., Aukenov N.E., Nurtazina A.U., Shakhanov T.E., Kozhakhmetova D.K. Interrelation of insulin resistance and polymorphisms of genes in lipid metabolism genes and renin-angiotensin-aldosterone system. Literature review. Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 4, pp. 50-59.Related publications:
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