FACTORS INFLUENCE ADHERENCE TO THERAPY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Background. Adherence is defined as “the degree to which a person’s behavior meets a doctor’s recommendation”. Poor adherence to therapeutic regimens is a common problem in patients with chronic diseases, including systemic lupus erythematosus (SLE). This leads to a higher risk of disease, hospitalization and poor prognosis in patients with lupus nephritis. Non-compliance with the treatment regimen is multifactorial for most patients and varies depending on unintended and intentional patterns. The level of low adherence of patients with SLE varies from 3% to 76%.
Currently, no studies are being conducted in the Republic of Kazakhstan (RK), factors affecting adherence to treatment of patients with SLE are being studied, and the consequences of low adherence are being evaluated.
The aim of our study was to study the effect of medical and social factors on adherence to therapy in patients with SLE.
Materials and methods. The continuous method, including all patients with a registered diagnosis of SLE. Moriski Treatment Adherence Scale (MMAS-4). The answers received are classified into two groups: “adherents of therapy” - persons who scored 4 points and “non-adherents of therapy” - patients who scored less than 4 points according to the results of the survey. The data processing procedure was performed in SPSS 20.0 for Windows. As a result, the analysis of the described statistics of qualitative and numerical results was carried out. Qualitative variables were presented in absolute numbers and their percentages. The Pearson chi-square test (χ2) was used to evaluate the difference in the groups. The critical value was considered significant at p <0.05.
The results of the study. According to MMAS-4, only 11 participants (16.4%). At the same time, 56 (83.6%) of respondents have a low commitment, periodically forgetting to follow the prescribed treatment, not observing its brevity or ignoring the reception with dangerous side effects. Low adherence was also specific for people with low income, older age, and long-term follow-up at a rheumatologist.
Conclusion. The research results indicate the high relevance of the problems of low adherence of patients with SLE to therapy. It is necessary to conduct national research and develop programs to prevent low adherence to the treatment of connective tissue diseases. Effective public health measures must be taken at the local and state level.
Yeldos A. Khamitov1,
Zaituna A. Khismetova 1,
Maiya V. Goremykina 1, https://orcid.org/0000-0003-1686-528X
Arkady – Avi Kotlyar 2, https://orcid.org/0000-0002-5070-0000
1 «Semey Medical University» NJSC, Semey city, Republic of Kazakhstan
2 Тhe Outpatient Pain Clinic and Institute of Cardiac Rehabilitation, of Kaplan Medical Center, Rehovot, Israel
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Khamitov Ye.A., Khismetova Z.A., Goremykina M.V., Tanysheva G.A.. Kotlyar A. Factors influence adherence to therapy in patients with systemic Lupus Erythematosus // Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 5, pp. 103-109.Related publications:
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