MODERN ASPECTS OF PREDICTION AND PREVENTION OF PRETERM LABOR ACCORDING TO PUBLISHED DATA. LITERATURE REVIEW.
Introduction. Premature rupture of membranes is one of the most important challenges in obstetric practice. Its relevance is undeniable because of the increase in maternal morbidity, neonatal morbidity and mortality. Births complicated by premature rupture of membranes at term, are according to the who over the last 5 years from 8,2% to 19,6%, with preterm births (before 37 weeks of gestation) from 5 to 35% and do not tend to decrease. It should also be noted that a premature discharge of amniotic fluid tends to re-development in subsequent births with a frequency of up to 20-32%. Purpose of the study: conducting a structured analysis of the literature data of studies of domestic and foreign authors on the prognosis and prevention of premature birth. Search strategy: the analysis of full-text sources in the Google Scholar, The Cochrane library, PudMed, E-library.ru, Ciberlenika databases was carried out. The search depth was 10 years from 2009 to 2019 Inclusion criteria: reports on randomized and cohort studies conducted on large populations, full versions of articles, dissertations, diagnostic protocols in Russian and English with open access. Information was searched by keywords. Exclusion criteria: articles, abstracts and scientific publications describing isolated cases, summaries of reports, personal communications and abstracts. During the search, 250 sources were found, of which 90 sources were selected and analyzed for a more detailed study. Results: Found published studies contained models for early prediction of preterm birth and adverse maternal and perinatal outcomes. The problem was identified in the absence of a clear unified algorithm of preventive measures to prevent premature birth and, consequently, adverse effects, both for the mother and the fetus. Conclusion: as a result of the lack of new solutions in the prevention and prevention of this pathology, this problem is quite relevant, requiring more in-depth study and adoption of a new model to solve it.
Anna S. Nikolaeva1, https://orcid.org/0000-0002-2642-5141 Guliash A.Tanysheva1, http://orcid.org/0000-0002-9074-6302 1 Department of Obstetrics and Gynecology, «Semey Medical University» NJSC, Semey city, Republic of Kazakhstan.
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Nikolaeva A.S., Tanysheva G.A. Modern aspects of prediction and prevention of preterm labor according to published data. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 5, pp. 23-36.

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