GEOGRAPHICAL DISTRIBUTION OF HBV GENOTYPES AND ASSOCIATION WITH CLINICAL MANIFESTATIONS OF CHRONIC VIRAL HEPATITIS B: REVIEW
Relevance. Chronic viral hepatitis B is a global public health problem due to high rates of infection (over 250 million people) and mortality (about 2 million people).The progression and clinical outcomes of the disease are influenced by many factors, starting still the biological properties of virus to genetic factors.
Aim. Analysis of literature devoted to the study of the prevalence of genotypes and their impact on the clinical course of chronic viral hepatitis B.
Search strategy. Search of scientific publications in the search engines Pub Med, Google Scholar, Google Academia, in the electronic scientific library eLibrary.ru, CyberLeninka. Inclusion criteria: search depth was 15 years (2004-2019); publications were in Russian, Kazakh and English; full-textured epidemiological and clinical studies.Exclusion criteria: publications with animal studies, studies related to the study of hepatitis C virus genotypes, with a response to antiviral therapy, recurring publications, conference proceedings, and clinical cases.
Results.Genotype D is most common and ubiquitous. Genotypes A, B, C have a characteristic geographical distribution in Europe, the countries of the African contingent (genotype A) and Asia, in particular in China (genotype B) and Korea (genotype C). Genotype B is more often associated with a favorable prognosis, while an unfavorable course of the disease is associated with the C genotype.
Conclusion.Thus, genotypes have a characteristic geographical distribution and affect the clinical course and outcomes of chronic viral hepatitis B.
Ainur K. Kumarbekova1, Imdat M. Efendiev1, Lidia A. Mukovozova1
1 «Semey Medical University» NJSC,
Semey city, Republic of Kazakhstan
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Kumarbekova A.K., Efendiev I.M., Mukovozova L.A. Geographical distribution of HBV genotypes and association with clinical manifestations of chronic viral hepatitis B: review // Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 6, pp. 11-23.Related publications:
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