GENOTYPING OF DRUG-RESISTANT CLINICAL ISOLATES OF M. TUBERCULOSIS IN KAZAKHSTAN
Tuberculosis, especially drug-resistant tuberculosis remains a major health problem in Kazakhstan. The incidence of multidrug-resistant tuberculosis in the country was increased by 8 times over 12 years from 1,7 to 13,5 per 100,000 population between 2003 and 2015. According to investigations in different countries Beijing M.tuberculosis family strains were associated with drug-resistance, specifically with multidrug-resistant tuberculosis. Aim of the study is to conduct genotyping of 192 drug-resistant clinical isolates of M.tuberculosis in Kazakhstan by spoligotyping technique and determine a correlation between drug resistance and Beijing M.tuberculosis genotype. Spoligotyping results demonstrated that Beijing genotype is the most widespread genotype among drug-resistant M. tuberculosis clinical isolates in Kazakhstan (74,48%). Determination of correlation between drug resistance and Beijing M.tuberculosis genotype showed that the genotype was found in more than 50% cases among polyresistant (70,9%) and multidrug resistant (87,75%) isolates.
Ulan Kozhamkulov1, http://orcid.org/0000-0002-9782-7631
Ainur Akhmetova1,2, http:// orcid.org/0000-0002-5557-3338
Venera Bismilda3, Scopus ID: 8441834800
Lyailya Chingissova3, Scopus ID: 39261046300
Ainur Akilzhanova1,2, http://orcid.org/0000-0001-6161-8355
1 Center for Life Sciences, National Laboratory Astana, Nazarbayev University,
Nur-Sultan city, Republic of Kazakhstan;
2Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University,
Nur-Sultan city, Republic of Kazakhstan;
3 National Scientific Center for Phthisiopulmonology of the Republic of Kazakhstan,
Almaty city, Republic of Kazakhstan.
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Kozhamkulov U., Akhmetova A., Bismilda V., Chingissova L., Akilzhanova A. Genotyping of drug-resistant clinical isolates of M. Tuberculosis in Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 4, pp. 71-79. doi 10.34689/SH.2020.22.4.007Related publications:
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