FEATURES OF CHANGES IN HEMATOLOGICAL PARAMETERS OF BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS. LITERATURE REVIEW
Introduction: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with alternating multi-system and broad spectrum clinics. Any tissue in the body could be involved in SLE like musculoskeletal, cutaneous, renal, neurological, hematological, vascular, pulmonary, gastrointestinal and ocular. Hematological abnormalities are common findings in patients with SLE. Sometimes, hematological abnormalities can be caused by the pathophysiology of SLE itself, but at other times they can be found in patients with SLE but not be a manifestation of SLE. Thus, it is important to distinguish hematological abnormalities as either manifestations of SLE, consequence of SLE treatment or as part of another blood cell dyscrasia.
Objective: Review of current literature on the peculiarities of changes in hematological parameters of blood, the level of white blood cells and white blood cell formulas depending on the activity and clinical manifestation of SLE disease.
Materials and methods: Search and analysis of material for writing articles were conducted on the information bases and web sites PubMed, Scopus, Medline, Web of Science, SpringerLink, Web of Knowledge (Thomson Reuters), Medicine, Science Direct, rheumatolog.ru, BMC (biomedcentral.com), cyberleninka.ru, BMJ (ard.bmj.com), Oxford academic (academic.oup.com). The depth of search operations included data for the last 15-20 years. From more than 70 literary sources, 63 were selected as analytical material for this article.
Results: Systemic lupus erythematosus (ICD-10) is an autoimmune disease of unknown etiology arising from genetic disorders of the regulatory process immune system development of immune inflammation in the tissues of many organs, education of special organisms of antibodies to core antigens and immune complexes of cells, with the development of immune inflammation in the tissues of many organs.
Conclusion: Hematological disorders are the most common sign of the disease in patients with SLE. It is important to distinguish between hematological disorders as a manifestation of SLE, the consequences of SLE treatment, or other types of blood dyscrasia. Our review considered the pathogenesis of SLE, leukopenia, neutropenia, lymphocytopenia, and peripheral cytopenia.
Gauhar T. Tassibekova1, https://orcid.org/0000-0002-1301-6496,
Ernest A. Kaliev2,
Aizada N. Kozhakhmetova2, https://orcid.org/0000-0002-0612-0957
1 Al-Farabi Kazakh National University, 2-nd year master's student in the specialty "Biomedicine",
Almaty, Republic of Kazakhstan;
2 Al-Farabi Kazakh National University, Department of Biophysics and Biomedicine,
Almaty, Republic of Kazakhstan.
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42. Mok C.C., Ying K.Y., Mak A., et al. Rheumatology. 2006. № 45 (4). Р. 425-429.
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22. Feletar M., Ibanez D., Urowitz M.B. The impact of the 1997 update of the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus:what has been changed? Arthritis Rheum. 2003. 48:2067–9. doi:10.1002/art.11167
23. Fernández M., Alarcón G.S., Calvo-Alén J., Andrade R., McGwin G Jr., Vilá L.M., Reveille J.D. LUMINA Study Group. A multiethnic, multicenter cohort of patients with systemic lupus erythematosus (SLE) as a model for the study of ethnic disparities in SLE. Arthritis Rheum 2007;57:576-584.
24. Fors Nieves C.E., Izmirly P.M. Mortality in systemic lupus erythematosus: an updated review. Curr. Rheumatol. Rep. 2016. 18, 21
25. Giannouli S., Voulgarelis M., Ziakas D., et al. Ann Rheum Dis. 2006. № 65. Р. 144-148.
26. Govoni M., Bortoluzzi A., Padovan M., Silvagni E., Borrelli M. The diagnosis and clinical management of the neuropsychiatric manifestations of lupus. Journal of Autoimmunity. 2016. 74, 41-72;
27. Haddy T.B., Rana S.R., Castro O. Benign ethnic neutropenia: what is a normal absolute neutrophil count? J Lab Clin Med 1999; 133: 15–22 doi:10.1053/lc.1999.v133.a94931
28. Hahn B.H., Anthony F.S, Stephen H.L, Dan L.L. Systemic lupus erythematosus. Harrison’s Principles of Internal Medicine. 2008. 17 edition. New York, NY, USA: McGraw-Hill;
29. Harvey A.M, Shulman L.E, Tumulty P.A et al. Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine (Baltimore) 1954;33:291–437 doi:10.1097/00005792-195412000-00001
30. Kapouzas G.A., Wallace D.J., Hahn B.H., eds Hematological and Lymphoid Abnomalities in SLE. DUBOIS’ Lupus erythmatosus and Related Syndomes. 8th edn Philadelphia: Elsevier, 2013:426–37.
31. Katsanis E., Hsu E., Luke K.H. et al. Systemic lupus erythematosus and sickle hemoglobinopathies: a report of two cases and review of the literature. Am J Hematol. 1987;25:211–14 doi:10.1002/ajh.2830250211
32. Lee Y.H., Ota F., Kim-Howard X., et. al. Rheumatology. 2007. № 46 (8). Р. 1274-1276.
33. Lam G.K., Petri M. Assessment of systemic lupus erythematosus. Clin. Exp. Rheumatol. 2005. 23, p 120-132;
34. Liu X., Qin H., Xu J. The role of autophagy in the pathogenesis of systemic lupus erythematosus. International Immunopharmacology. 2016. 40. 351-361
35. Lee H.T, Wu T.H., Lin C.S., Lee C.S., Wei Y.H. The pathogenesis of systemic lupus erythematosus - From the viewpoint of oxidative stress and mitochondrial dysfunction. Mitochondrion. 2016. 30. 1-7.
36. Manson J.J., Rahman A. Systemic lupus erythematosus. Orphanet Journal of Rare Diseases. 2006.1.6. https://doi.org/10.1186/1750-1172-1-6
37. Martinez-Banos D., Crispin J.C., Lazo-Langner A. et al. Moderate and severe neutropenia in patients with systemic lupus erythematosus. Rheumatology (Oxford) 2006;45:994 doi:10.1093/rheumatology/kel016
38. Massardo L., Metz C., Pardo E. et al. Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Lupus. 2009; 18: 539–46 doi:10.1177/0961203308099973
39. Manuel F. Ugarte-Gil, Graciela S. Alarcón. History of Systemic Lupus Erythematosus. MPH. 2016. DOI: 10.1093/med/9780198739180.003.0001
40. Manson J.J, Isenberg D.A. The pathogenesis of systemic lupus erythematosus. Neth J Med. 2003, 61: 343-346
41. Matsuyama W., Yamamoto M., Higashimoto I. et al. TNF-related apoptosis-inducing ligand is involved in neutropenia of systemic lupus erythematosus. Blood 2004;104:184–91 doi:10.1182/blood-2003-12-4274
42. Mok C.C., Ying K.Y., Mak A., et al. Rheumatology. 2006. № 45 (4). Р. 425-429.
43. Petri M., Orbai A.M., Alarcon G.S. et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64:2677–86 doi:10.1002/art.34473 [PMC free article]
44. Petri M. The effect of race on incidence and clinical course in systemic lupus erythematosus. The Hopkins Lupus Cohort. J Am Med Womens Assoc. 1998; 53: 9-12.9.
45. Rivero S.J, Diaz-Jouanen E., Alarcon-Segovia D. Lymphopenia in systemic lupus erythematosus. Clinical, diagnostic, and prognostic significance. Arthritis Rheum 1978;21:295305 doi:10.1002/art.1780210302
46. Romero-Diaz J., Isenberg D., Ramsey-Goldman R. Measures of adult systemic lupus erythematosus. Arthritis Care Res. 2011. 63 (011). doi: 10.1002/acr.20572
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49. Sasidharan P.K., Bindiya M., Sajeeth Kumar. Systemic lupus erythematosus - a hematological problem. J Blood Disorders Transf. 2013,4:6 DOI: 10.4172/2155-9864.1000168
50. Singh S., Kumar L., Khetarpal R., et al. Clinical and immunological profile of SLE: some unusual features. Indian Pediatrics. 1997;34 (11):979–986.
51. Sultan S.M., Begum S., Isenberg D.A. Prevalence, patterns of disease and outcome in patients with systemic lupus erythematosus who develop severe haematological problems. Rheumatology (Oxford). 2003. 42: 230-234.
52. Silva L.M., Garcia A.B., Donadi E.A. Increased lymphocyte death by neglect-apoptosis is associated with lymphopenia and autoantibodies in lupus patients presenting with neuropsychiatric manifestations. J Neurol. 2002;249:1048–54 doi:10.1007/s00415-002-0781-6
53. Starkebaum G., Price T.H., Lee M.Y. et al. Autoimmune neutropenia in systemic lupus erythematosus. Arthritis Rheum. 1978; 21: 504–12 doi:10.1002/art.1780210503
54. Tsao B.P., Grossman J.M. Genetics and systemic lupus erythematosus. Curr Rheumatol Rep. 2001;3:183–190. doi: 10.1007/s11926-001-0017-2.
55. Sugimoto T., Soumura M., Tanaka Y. et al. Early morning neutropenia in a patient with systemic lupus erythematosus. Mod Rheumatol. 2006; 16: 267–8 doi:10.3109/s10165-006-0483-5
56. Tan E.M., Cohen A.S., Fries J.F. et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982; 25:1271–7 doi:10.1002/art.1780251101
57. Tench C.M., McCurdie I., White P.D., D'Cruz D.P. The prevalence and associations of fatigue in systemic lupus erythematosus. Rheumatology. Oxford. 2000. 1249–1254.
58. Tiefenthaler M., Bacher N., Linert H., et al. Lupus. 2003. № 12. Р. 321-441
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Tasibekova G.T., Kaliev E.A., Kozhakhmetova A.N. Features of changes in hematological parameters of blood in Systemic lupus erythematosus. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 5, pp. 57-67. doi:10.34689/SH.2020.22.5.005Related publications:
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