THE SURGICAL TREATMENT OF HODGKIN LYMPHOMA OF THE THYMUS GLAND AND THE LATE POST-OPERATIVE COMPLICATION-RELAXATION OF BOTH DOMES OF THE DIAPHRAGM
This article presents the results of complex treatment of Hodgkin lymphoma involving the thymus gland. At the first stage, a radical operation was performed- removal of a massive mediastinal tumor, followed by chemotherapy. Recurrence-free (14-year) examination of the patient revealed a late postoperative complication-relaxation of both diaphragm domes, which required surgical correction.
Sergey D. Fokeev1, Stanislav Yu. Kapitulin1, Yelena S. Kazantseva2, Elina K. Kapitulina3, Marat K. Syzdykbayev4 1 FSBEI «Altai state medical University» Ministry Of Health Of Russia, Department of faculty surgery named after Professor I. I. Neymark and hospital surgery, with a course of surgery of APE, Barnaul c., Russia; 2ClinicNIITO, Barnaul c., Russian Federation; 3 KGBUZ "City Hospital №5, Barnaul», Barnaul c., Russia; 4 NCJSC «Semey Medical University», Semey, Republic of Kazakhstan.
1. Лазутин Ю.Н., Карташов С.З., Зинькович С.А., Кабанов С.Н., Лейман И.А. Современные подходы к лечению больных с опухолями средостения // Известия Самарского научного центра Российской академии наук. 2009, Т. 11, No5(2), С. 468-471. 2. Мазурок Л.А., Коломейцев О.А., Тумян Г.С., Ковригина А.М. Первичная медиастинальная В-крупноклеточнаялимфома // Онкогематология. 2007. №2. С.18-23. 3. Потешкина Н.Г., Трошина А.А., Маслова М.Ю., Лысенко М.А., Самсонова И.В., Желнова Е.И. Образования средостения в клинической практике // Медицинский Совет. 2018; №5:С. 104-108. 4. Сушко А.А., Прокопчик Н.И., Можейко М.А., Кропа Ю.С., Богатыревич И.Ч. Диагностика и лечение опухолей и опухолевидных образований средостения // Журнал Гродненского государственного медицинского университета. 2015. №3, С. 51-55. 5. Трахтенберг А.Х., Пикин О.В. Злокачественные опухоли средостения. В кн. Клинические рекомендации. Онкология 2006. – под редакцией В.И. Чиссова и С.Л. Дарьяловой. – М., 2006.-С.246-266. 6. Шавлохов В. С., Карагюлян С.Р.,Моисеева Т.Н., Джумабаева Б.Т. Хирургическое лечение рецидивов опухолей средостения и лёгких у больных лимфогранулематозом и диффузной В-клеточной лимфомой // Гематология и трансфузиология. 2012. т. 57, №1 С.18-23 7. Шалыга И.Ф., Гришаков В.В., Мартемьянова Л.А и др. Лимфома Ходжкина с экстранодулярными проявлениями // Проблемы здоровья и экологии. 2017; №2(52): С. 106-110. 8. Allen P.B., Gordon L.I. Frontline Therapy for Classical Hodgkin Lymphoma by Stage and Prognostic Factors // Clinical Medicine Insights: Oncology. SAGE Publications Ltd, 2017. Vol. 11. 9. Aror A.R., Prakasha S.R., Seshadri S., et al. A study of clinical characteristics of mediastinal mass // J. Clin. Diagn. Res.2014; 8: 77–80. 10. Baram A., Tayeb Z.A. Mediastinal Masses: Retrospective Single Center Based Study // J Cancer SciTher 8: 252-256. 2016. 11. Behringer K., Thielen I., Mueller H. et al. Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial // Ann Oncol. 2012;23(7):1818-25. 12. Eichenauer D.A., Engert A., Andre M. et al.Hodgkin’s lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and followup // Ann. Oncol., 2014, 25 (suppl.3): 70-5. 13. Engert A., Haverkamp H., Kobe C. et al. Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin"s lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial // Lancet. 2012;379(9828):1791-1799. 14. Harris N.L. Shades of grey between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications // Mod Pathol. 2013; 26: 57-70. 15. Hu B. et al. Phase-I and randomized phase-II trial of panobinostat in combination with ICE (Ifosfamide, carboplatin, etoposide) in relapsed or refractory classical hodgkin lymphoma // Leuk. Lymphoma. TaylorandFrancisLtd, 2018. Vol. 59, № 4. P. 863– 870. 16. Jagadeesh D., Diefenbach C., Evens A. Hodgkin lymphoma in older patients: challenges and opportunities to improve outcomes // HematOncol 2013;31 (suppl. 1):69-75. 17. Leticia Quintanilla-Martinez, Fend F. Mediastinal Gray Zone Lymphoma // Haematologica April 2011 96: 496-499. 18. Meyer R.M., Gospodarowicz M.K., Connors J.M. et al. ABVD Alone versus Radiation-Based Therapy in Limited-Stage Hodgkin"s Lymphoma // N Engl J Med. 2012; 366:399-408. 19. Nikolaenko L., Chen R. Current strategies for salvage treatment for relapsed classical Hodgkin lymphoma // Ther. Adv. Hematol. 2017. Vol. 8, № 10. P. 293–302. 20. Younes A., Gopal A.K., Smith S.E. et al. Results of a Pivotal Phase II Study of BrentuximabVedotin for Patients With Relapsed or Refractory Hodgkin"s Lymphoma // J ClinOncol 2012;30:2183-2189. References: 1. Lazutin Yu.N., Kartashov S.Z., Zin'kovich S.A., Kabanov S.N., Leiman I.A. Sovremennye podkhody k lecheniyu bol'nykh s opukholyami sredosteniya [Modern approaches to the treatment of patients with mediastinal tumors]. Izvestiya Samarskogo nauchnogo tsentra Rossiiskoi akademii nauk [Bulletin of the Samara Scientific Center of the Russian Academy of Sciences]. 2009, V.11, № 5(2), pp. 468-471.[in Russian] 2. Mazurok L.A., Kolomeitsev O.A., Tumyan G.S., Kovrigina A.M. Pervichnaya mediastinalnaya B-krupnokletochnaya limfoma [Primary mediastinal large B-cell lymphoma]. Oncohematologiya [Oncohematology]. 2007. № 2. pp.18-23. 3. Poteshkina N.G., Troshina A.A., Maslova M.Yu., Lysenko M.A., Samsonova I.V., Zhelnova E.I. Obrazovanya sredostenya v klinicheskoi praktike [Mediastinal formation in clinical practice]. Meditsinskii Sovet [Medical advice]. 2018. № 5. p. 104-108. 4. Sushko A.A., Prokopchik N.I., Mozheiko M.A., KropaYu.S., Bogatyrevich I.Ch. Diagnostika I lechenie opukholei I opukholevidnykh obrazovanii sredostenia [Diagnostics and treatment of tumors and tumor-like formations of the mediastinum]. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta [Journal of Grodno State Medical University]. 2015. № 3, pp. 51-55. 5. Trakhtenberg A.Kh., Pikin O.V. Zlokachestvennye opukholi sredostenia [Malignant tumors of the mediastinum]. In the book. Clinical recommendations. Oncology 2006. - edited by V.I. Chissova and S.L. Daryalova. - M., 2006. - р.246-266. 6. Shavlokhov V.S., Karagyulyan S.R., Moiseeva T.N., Dzhumabayeva B.T. Кhirurgicheskoe lechenie retsidivov opukholei I legkikh u bolnykh limfogranulematozom I diffuznoi B-kletochnoi limfomoi [Surgical treatment of recurrent tumors of the mediastinum and lungs in patients with lymphogranulomatosis and diffuse B-cell lymphoma]. Hematologiya i transfusiologiya. [Hematology and transfusiology]. 2012. v. 57, № 1, pp.18-23. 7. Shalyga I.F., Grishakov V.V., Martemyanova L.A. et al. Limfoma Khodjkina s extranodullyarnymi proyavlenyami [Hodgkin's lymphoma with extranodular manifestations]. Problemy zdorov'ya i ekologii [Health and ecology problems]. 2017; No. 2 (52), pp. 106-110. 8. Allen P.B., Gordon L.I. Frontline Therapy for Classical Hodgkin Lymphoma by Stage and Prognostic Factors. Clinical Medicine Insights: Oncology. SAGE Publications Ltd, 2017. Vol. 11. р.11-25 9. Aror A.R., Prakasha S.R., Seshadri S., et al. A study of clinical characteristics of mediastinal mass. J. Clin. Diagn. Res. 2014; 8: 77–80. 10. Baram A., Tayeb Z.A. Mediastinal Masses: Retrospective Single Center Based Studyю J Cancer Sci. Ther. 2016. 8: 252-256. 11. Behringer K., Thielen I., Mueller H. et al. Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial. Ann Oncol. 2012; 23(7):1818-25. 12. Eichenauer D.A., Engert A. et al. Hodgkin’s lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and followup. Ann. Oncol., 2014, 25 (suppl.3): 70-5. 13. Engert A., Haverkamp H., Kobe C. et al. Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin"s lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial. Lancet. 2012;379(9828):1791-1799. 14. Harris N.L. Shades of grey between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications. Mod Pathol. 2013; 26: 57-70. 15. Hu B. et al. Phase-I and randomized phase-II trial of panobinostat in combination with ICE (Ifosfamide, carboplatin, etoposide) in relapsed or refractory classical hodgkin lymphoma. Leuk. Lymphoma. Taylor and Francis Ltd, 2018. Vol. 59, № 4. P. 863– 870. 16. Jagadeesh D., Diefenbach C., Evens A. Hodgkin lymphoma in older patients: challenges and opportunities to improve outcomes. Hemat Oncol 2013;31(suppl. 1):69-75. 17. Leticia Quintanilla-Martinez, Fend F. Mediastinal Gray Zone Lymphoma. Haematologica April. 2011. 96: 496-499. 18. Meyer R.M., Gospodarowicz M.K., Connors J.M. et al. ABVD Alone versus Radiation-Based Therapy in Limited-Stage Hodgkin"s Lymphoma. N Engl J Med. 2012; 366:399-408. 19. Nikolaenko L., Chen R. Current strategies for salvage treatment for relapsed classical Hodgkin lymphoma. Ther. Adv. Hematol. 2017. Vol. 8, № 10. P. 293–302. 20. Younes A., Gopal A.K., Smith S.E. et al. Results of a Pivotal Phase II Study of BrentuximabVedotin for Patients With Relapsed or Refractory Hodgkin"s Lymphoma. J Clin Oncol. 2012;30:2183-2189.
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Fokeev S.D., Kapitulin S.Yu., Kazantseva E.S., Kapitulina E.K., Sydykbayev M.K. The surgical treatment of Hodgkin lymphoma of the thymus gland and the late post-operative complication-relaxation of both domes of the diaphragm // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 2, pp. 155-161. doi 10.34689/SH.2021.23.2.017

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