DETERMINATION OF THE PROGNOSTIC SIGNIFICANCE OF OXIDATIVE STRESS AND THE STATE OF THE ANTIOXIDANT SYSTEM IN ISCHEMIC STROKE
Introduction. Oxidative stress is one of the universal pathophysiological mechanisms in ischemia and reperusion. In patients with ischemic stroke, its severity and the state of the antioxidant system directly in the ischemic zone are of great interest. This can be achieved by performing an invasive intervention on the cerebral arteries.
Research purpose. Comparative characteristics and determination of the prognostic significance of the severity of oxidative stress and the antioxidant system in ischemic stroke.
Materials and methods. The design of the study was a cross-sectional single-center clinical study. The study included 113 patients with acute ischemic stroke, hospitalized during the first day after its start. 101 men and 12 women were examined, of which 32 were aged 50-60 years, 64 were 61-70 years old, and 17 were 71-80 years old. On the first day after the development of a stroke, venous blood was taken (5 ml). When performing an invasive intervention, blood was taken directly from the vessels of the brain in a volume of 2 ml.
The content of diene conjugates, malondic dialdehyde as lipid peroxidation products, thiol-disulfide ratio and superoxide dismutase activity as parameters of the antioxidant system were studied.
Results. Regular changes in the content of lipid peroxidation products and the activity of the antioxidant system were determined. In the early stages after the development of a stroke in the peripheral blood, there was an increase mainly in the content of DC and a decrease in TDR, while in the blood from the stroke area, an increase in the secondary products of lipid peroxidation and inhibition of the enzymatic link of the antioxidant system were detected.
A high degree of correlation of indicators with the size of the stroke and functional results in the study of blood from the stroke area was revealed.
Conclusions:
1. The study of indicators of lipid peroxidation and antioxidant protection in stroke in blood obtained from the area of cerebral ischemia is more consistent with the size of ischemic damage than in peripheral blood.
2. The degree of violation of lipid peroxidation and antioxidant protection in blood obtained from the area of cerebral ischemia has a great prognostic value in relation to the development of functional failure in the early period after a stroke.
Alzhan A. Baubekov1,3, https://orcid.org/0000-0001-7197-4871
Yergali M. Meirbekov2, https://orcid.org/0000-0002-7609-0300
Tolegen J. Egemberdiev3, https://orcid.org/0000-0001-6518-5825
Venera K. Israilova3, https://orcid.org/0000-0001-7778-9618
Nazarbek B. Omarov4, https://orcid.org/0000-0003-3262-1410
1. "Private Сlinic Almaty", Almaty, Republic of Kazakhstan;
2. National Scientific Research Center for Surgery named after A.N. Syzganov,
Almaty, Republic of Kazakhstan;
3. NJSC "Kazakh National Medical University named after Asfendiyarov",
Almaty, Republic of Kazakhstan;
4. NJSC "Semey Medical University", Semey, Republic of Kazakhstan.
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Baubekov A.A., Meirbekov Ye.M., Egemberdiev T.J., Israilova V.K., Omarov N.B. Determination of the prognostic significance of oxidative stress and the state of the antioxidant system in ischemic stroke // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 5, pp. 97-104. doi 10.34689/SH.2022.24.5.013Related publications:
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