Online ISSN: 3007-0244,
Print ISSN:  2410-4280
ANTITHROMBOTIC THERAPY IN PATIENTS WITH ATRIAL FIBRILLATION WITH ACUTE CORONARY SYNDROME AFTER PERCUTANEOUS CORONARY INTERVENTION. REVIEW.
Introduction. The review is devoted to the issues of antithrombotic combinations in patients with atrial fibrillation (AF) who underwent percutaneous coronary intervention (PCI) and stenting. Objective: To analyze the main literature and clinical recommendations on the efficacy and safety of antithrombotic combinations in patients with AF who have undergone PCI and stenting. Search strategy. The search for scientific publications was carried out in the search engines PubMed, Web of Science, Google Scholar, in the electronic scientific libraries eLibrary, CyberLeninka. The search depth is 15 years (2006-2021). Search for information on the efficacy and safety of antithrombotic combinations in patients with AF who have undergone PCI and stenting. Results. There are currently a lot of studies comparing the use of oral anticoagulants (OAC) in patients with AF after PCI. With the appearance of the results of large randomized trials, the recommendations for antithrombotic therapy in this category of patients have been updated. We aim to analyze the currently available literature on the problem of TAT and DAT in patients with AF and acute coronary syndrome (ACS), and provide data on the risks and benefits. Conclusions. A review of the current literature on antithrombotic therapy in patients with AF who have undergone PCI and subsequent coronary artery stenting shows that the preferred regimen is double antithrombotic therapy (DAT) consisting of a P2Y12 inhibitor in combination with UAC, and triple antithrombotic therapy (TAT) exposes them to an increased risk of bleeding. Decisions regarding specific agents and duration of treatment should be based on thrombotic risk, bleeding risk and patient preferences.
Assel A. Kassymova1, https://orcid.org/0000-0001-9333-4146 Jamilya A. Mansurova1, https://orcid.org/0000-0003-2439-2056 Lyudmila K. Karazhanova1, http://orcid.org/0000-0002-4719-6034 Aisulu S. Zhunuspekova1, https://orcid.org/0000-0002-2413-317X 1 NCJSC «Semey Medical University», Department of Cardiology and Interventional Arrhythmology, Semey, Republic of Kazakhstan.
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Kassymova A.A, Mansurova J.A., Karazhanova L.K., Zhunuspekova A.S. Antithrombotic therapy in patients with atrial fibrillation with acute coronary syndrome after percutaneous coronary intervention. Review // Nauka i Zdravookhranenie [Science &Healthcare]. 2022, (Vol.24) 6, pp.143-151. doi 10.34689/SH.2022.24.6.019

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