COMPARATIVE ANALYSIS OF FACTORS ASSOCIATED WITH THE SEVERE COURSE OF COVID-19 IN THE AGE GROUPS UNDER 60 AND OVER 60 YEARS OF AGE
Introduction: Coronavirus infection is a disease that causes respiratory failure and complications in certain groups of people, leading to death. The factors associated with the severe course of COVID-19 have been fairly well studied by now; at the present stage, it is necessary to search for and study them in separate groups of people that differ in age, gender, ethnicity, the presence of background diseases, etc. to develop more personalized approaches to severe disease prevention.
Objective: To conduct a comparative analysis of the factors associated with the severe course of COVID-19 in people under and over 60 years of age and evaluate their prognostic significance in combination of factors.
Materials and methods: A retrospective analysis of the clinical and laboratory parameters of 812 COVID-19 patients was carried out. Multiple logistic regression analysis was used to identify factors associated with the development of severe COVID-19. ROC analysis was performed to assess the prognostic significance of the set of identified statistically significant factors in the development of a severe course of COVID-19.
Results: Multivariate logistic regression analysis showed that patients under 60 diabetes mellitus (OR=2,561, p=0,048), lymphopenia (OR=2,133, p=0,030), and pneumonia at admission (OR=2,556, p=0,011), rapid breathing (OR=3,497, p=0,001), low saturation (OR=4,076, p=0,006) were significantly associated with the development of severe COVID-19.
At the same time, in patients older than 60 years, the presence of diabetes mellitus (OR=1,899, p=0,029), rapid breathing (OR=2,338, p=0,007) and low saturation (OR=4,248, p<0,0001) were significantly associated with the development of a severe course of COVID-19.
In groups under 60 and over 60 years of age, the prognostic value of the combination of all statistically significant factors corresponding to the groups was equal to the average level (AUC=0,760 and AUC=0,709, respectively)
Conclusion: Factors associated with the development of a severe course of COVID-19 in elderly and middle-aged people have some differences related to the pathogenesis of the disease. For individuals under 60 years of age, factors associated with severe COVID-19 are diabetes mellitus, the presence of pneumonia on admission, dyspnea, low oxygen saturation, and lymphopenia. For individuals over 60 years of age, factors associated with severe COVID-19 are the presence of diabetes mellitus, shortness of breath, and low saturation. The combination of all the studied factors significantly increases the risk of developing a severe course of COVID-19 in both age groups.
Arailym Abilbayeva1, https://orcid.org/0000-0001-5081-5492
Anel Tarabayeva1, https://orcid.org/0000-0002-2851-2396
Elmira Bitanova1, https://orcid.org/0000-0003-3976-9653
Gulzhana Idrissova1, https://orcid.org/0000-0002-7072-2565
Moldir Sadykova1, https://orcid.org/0000-0002-2277-6331
Uldana Sakhadin1, https://orcid.org/0000-0003-4233-9611
Karina Abayeva1, https://orcid.org/0000-0002-7980-1286
1 Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
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Абильбаева А.А., Тарабаева А.С., Битанова Э.Ж., Идрисова Г.М., Садыкова М.Б., Сахадин У.К., Абаева К.А. Сравнительный анализ факторов, ассоциированных с тяжелым течением COVID-19 в возрастных группах до 60 лет и старше 60 лет // Наука и Здравоохранение. 2023. 1 (Т.25). С. 7-15. doi 10.34689/SH.2023.25.1.001 Abilbayeva A., Tarabayeva A., Bitanova E., Idrissova G., Sadykova M., Sakhadin U., Abayeva K. Comparative analysis of factors associated with the severe course of COVID-19 in the age groups under 60 and over 60 years of age // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 7-15. doi 10.34689/SH.2023.25.1.001Related publications:
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