COMPARATIVE CHARACTERISTICS OF ENERGY METABOLISMIN LYMPH NODES OF SMALL INTESTINE OF DESCENDANTSOF RATS OF DIFFERENT AGE EXPOSED TO 60Co

Abstract

The purpose of research was study the changes of activity energy metabolism enzymes -
succinatedehydrogenase and citohromoksidase in lymph nodes of the small intestine at the generation
descendents in 2, 5 and 10-monthly ages of white rats subjected to low dose (0,2 Gr) of gamma
radiation. Experimental studies were carried out on white outbred 90 rats of both sexes which was
generation of animals exposed to radiation. The study status of energy metabolism in the lymph nodes of the small intestine in 2, 5 and 10-monthly intact descendants and the descendants of animals
subjected to gamma-radiation at a dose of 0,2 Gr. Irradiation was performed in czech radiotherapy
device «Teragam» rays of 60Co. This method was developed by topometric-dosimetric preparation of
experimental animals to radiation exposure. In the lymph nodes of the small intestine gomogenats were
determined the activity of succinatedehydrogenase (S. Tapbergenov, 1971), citohromoksidase
(R.Krivchenkova, 1974). The results of the study were generally accepted by SPSS program. The
comparison conducted by the criterion of t-Student.
Our experimental study showed that in the lymph nodes of the small intestine in 2-monthly of the
descendants of the irradiated white rats the activity of SDG is not reliable changes, and the 5-monthly
descendants irradiated animals characterized that lymph nodes of the small intestine there is no reliable
changes. The 10-monthly descendants of animals subjected to low-dose gamma radiation activity of
SDG in the lymph nodes of the small intestine to 20,13% (p<0,05).
So it is set that in researched lymph nodes of the small intestine at the 10-monthly descendants of
rats subjected to low dose (0,2 Gr) of gamma-radiation compared to 2 and 5-monthly descendants of
the exposed rats there has been a significant reduction of activity of SDG and CHO enzymes.