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PREVALENCE AND SEVERITY OF SOMATIC DISTRESS AND FATIGUE AMONG RESIDENTS OF EAST KAZAKHSTAN REGION EXPOSED TO RADIATION DUE TO THE ACTIVITY OF THE SEMIPALATINSK NUCLEAR TEST SITE
Background: since Kazakhstan belongs to the range of industrialized world nations, most of its territory is affected by anthropogenic and man-induced risk factors, which contribute to the development of unfavorable ecological situation that has negative impact on the population health. Nuclear weapons tests at the Semipalatinsk nuclear test site have caused significant adverse changes in the habitat of hundreds of thousands of people who are now forced to live and conduct economic activities in territories contaminated with radionuclides. Studying the long-term effects of small radiation doses...
Толығырақ
2018 жыл | Шығарылым: 5 | Беттер: 125-134

POLYMORPHISMS OF GENES IN HYPERTENSION: RENIN - ANGIOTENSIN - ALDOSTERONE SYSTEM. REVIEW

The study of polymorphisms of genes responsible for the development of arterial hypertension is a promising direction of medicine. Hypertension is a multifactorial disease that depends on lifestyle, environment and nutrition, as well as polymorphisms of genes. Polymorphisms of the genes of the renin - angiotensin - aldosterone system play an important role in the pathogenesis of hypertension.

Толығырақ
2018 жыл | Шығарылым: 1 | Беттер: 116-130

RISK OF DISORDERS OF NONSPECIFIC RESISTANCE DUE TO LONG-TERM EXPOSURE TO RADIATION IN SMALL DOSES
Background: long-term exposure to ionizing radiation in small doses on the human body is manifested by violations of the adaptive response of regulatory systems to stress.

Aim: to perform a systematic search of valid scientific data in order to assess the disorders of nonspecific resistance in the human organism due to long-term exposure to radiation in small doses

Materials and methods. The search for scientific publications was carried out in the evidence-based medicine’s databases (PubMed, Cochrane Library, ResearchGate, Google Scholar) and in the electron...
Толығырақ
2017 жыл | Шығарылым: 5 | Беттер: 158-171

POLYMORPHISM OF IL10 GENE AT -1082G/A POSITION IN PATIENTS WITH ERYSIPELAS
The aim of this study is reveal the association of polymorphism of IL10 gene (rs1800896) at 1082 GA position with the erysipelas in Kazakh population.
Materials and methods. The polymorphism of IL10 gene (rs1800896) was assessed in 206 patients with erysipelas and 422 control subjects. Of them 143 patients with primary erysipelas and 63 with recurrence erysipelas. Genomic DNA was extracted from blood for genotyping. Genotyping of polymorphism of IL10 gene (-1082 GA) was conducted by   method of polymerase chain reaction in real time. Pearson’s Chi tests ...
Толығырақ
2016 жыл | Шығарылым: 3 | Беттер: 34-45