ГИПЕРГОМОЦИСТЕИНЕМИЯ КАК ФАКТОР РИСКА СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ
Кардиоваскулярные заболевания занимают первое место среди причин смертности населения. В связи с этим, возрастает актуальность проблемы профилактики, которая направлена на выявление и устранение факторов риска, к которым относят повышенный уровень гомоцистеина в крови.
В последние годы активно изучается возможность применения витаминов группы В при сосудистых и ней родегенеративных заболеваниях. Дефицит витаминов В6, В12, В9, возникший в результате особенностей диеты и нарушения абсорбции, признан одним из основных факторов развития гипергомоцистеинемии. Установлено, что применение препаратов витаминов группы В позволяет уменьшить содержание гипергомоцистеинемии в крови. На основании гомоцистеиновой теории развития атеросклероза объясняется наличие возможной связи гипергомоцистеинемии с формированием сосудистой патологии. Установлено, что применение высоких доз витаминов группы В способствовало значительному снижению прогрессирования атеросклероза на ранних стадиях.
В статье описана роль гипергомоцистеинемии как фактора риска сердечно-сосудистых заболеваний. Проведен обзор доказательной базы и отечественных исследований. Сделаны выводы с учетом региональных особенностей и влияния радиационного фактора.
Цель исследования: проведение поиска литературы по изучению гипергомоцистеинемии как фактора риска сердечно-сосудистых заболеваний.
Материалы и методы: Для достижения поставленной цели был выполнен систематический поиск литературы в онлайн ресурсах. Было найдено 278 источников, из которых для последующего анализа было отобрано - 63. Ключевые пункты формирования поисковых запросов для поиска литературы были представлены следующими элементами: гомоцистеин, витамины группы В, фолиевая кислота, сердечно-сосудистый риск.
Результаты и выводы: Для пациентов группы высокого риска, к которым относятся пациенты, имеющие личную и семейную предрасположенность к ранней сердечно-сосудистой недостаточности, а также лица с нарушением питания, (синдромом сниженной абсорбции), гипотиреодизмом, почечной недостаточностью, системной красной волчанкой; принимающих такие лекарственные средства, как никотиновая кислота, теофиллин, метотрексат, допамин и те, кто подвергался воздействию оксида азота, необходимо проводить определение плазменного гомоцистеина.
Людмила К. Каражанова, http://orcid.org/0000-0002-4719-6034
Айсулу С. Жунуспекова, http://orcid.org/0000-0003-1496-3281
Государственный медицинский университет города Семей,
Кафедра интернатуры по терапии
г. Семей Казахстан.
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Каражанова Л.К., Жунуспекова А.С. Гипергомоцистеинемия как фактор риска сердечно-сосудистых заболеваний (Обзор литературы) / / Наука и Здравоохранение. 2016. №4. С. 129-144. Karazhanova L.K., Zhunuspekova A.S. Hyperhomocysteinemia as a risk factor of cardiovascular diseases (Literature review). Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 4, pp. 129-144. Қаражанова Л.Қ., Жүніспекова А.С. Гипергомоцистеинемия жүрек – қантамыр ауруларының қауіп-қатер факторы ретінде (Әдебиеттерге шолу) / / Ғылым және Денсаулық сақтау. 2016. №4. Б. 129-144.Похожие публикации:
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