GENOMIC INSTABILITY IN ONCOCYTIC FOLLICULAR ADENOMA OF THE THYROID
Oncocytic follicular adenomas of the thyroid are neoplasmas of follicular cell origin that are predominantly composed of large polygonal cells with eosinophilic and granular cytoplasm. However, the pathological characteristics of these tumors are the largely unexplored. The diagnosis of malignancy is reliably based on histological evidence of capsular invasion or vascular invasion, extrathyroidal local tissue invasion, and nodal or distant metastasis. Both the initiation and progression of cancer can be caused by an accumulation of genetic mutations that can induce genomic instability.
Zhanna U. Kozykenova1, http://orcid.org/0000-0001-7420-2279 Gulzira S. Shalgimbayeva2, Zhanna B. Mussazhanova3, http://orcid.org/0000-0002-7315-7725 1 NCJSC “Semey medical university”, Semey c., Republic of Kazakhstan; 2 KGP on the REM “Almaty Oncological Center”, Almaty c., Republic of Kazakhstan; 3 Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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Kozykenova Zh., Shalgimbayeva G.S., Mussazhanova Zh.B. Genomic instability in oncocytic follicular adenoma of the thyroid // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 4, pp. 133-136. doi 10.34689/SH.2022.24.4.017

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