GENOMIC INSTABILITY IN ONCOCYTIC FOLLICULAR ADENOMA OF THE THYROID
Oncocytic follicular adenomas of the thyroid are neoplasmas of follicular cell origin that are predominantly composed of large polygonal cells with eosinophilic and granular cytoplasm. However, the pathological characteristics of these tumors are the largely unexplored.
The diagnosis of malignancy is reliably based on histological evidence of capsular invasion or vascular invasion, extrathyroidal local tissue invasion, and nodal or distant metastasis. Both the initiation and progression of cancer can be caused by an accumulation of genetic mutations that can induce genomic instability.
Zhanna U. Kozykenova1, http://orcid.org/0000-0001-7420-2279
Gulzira S. Shalgimbayeva2,
Zhanna B. Mussazhanova3, http://orcid.org/0000-0002-7315-7725
1 NCJSC “Semey medical university”, Semey c., Republic of Kazakhstan;
2 KGP on the REM “Almaty Oncological Center”, Almaty c., Republic of Kazakhstan;
3 Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
1. Carcangiu M.L., Bianchi S., Savino D. et al. Follicular Hurthle cell tumors of the thyroid gland // Cancer. 1991. Vol. 63. P. 1944-1953.
2. Coleman W.B., Tsongalis G.J. The role of genomic instability in human carcinogenesis // Anticancer Res. 1999. Vol.19. P. 4645-4664.
3. Hag M., Harmer C. Differentiated thyroid carcinoma with distant metastases at presentation: prognostic factors and outcome // Clin Endocrinol (Oxf). 2005. Vol.63. P.87-93.
4. Montone K.T., Baloch Z.W., LiVolsi V.A. The thyroid Hurthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review // Arch Pathol Lab Med. 2008. Vol. 132. P. 1241-1250.
5. McDonald M.P.,Sanders L.E., Silverman M.L. et al. Hurthle cell carcinoma of the thyroid gland: prognostic factors and resalts of surgical treatment // Surgery. 1996. Vol. 120. P.1000-1004; discussion 1004-1005.
6. Nakashima M., Suzuki K., Meirmanov S. et al. Foci formation of P53-binding protein 1 in thyroid tumors: activation of genomic instability during thyroid carcinogenesis // Int J Cancer. 2008. Vol.122. P.1082-1088.
7. Rosai J., Kuhn E., Carcangiu M.L. Pitfalls in thyroid tumour pathologi // Histopathology. 2006. Vol. 49. P.107-120.
8. Rappold I., Iwabuchi K., Date T., Chen J. Tumor suppressor p53 protein 1 (53BP1) is involved in DNA damage-signaling pathways // J Cell Biol. 2001. Vol. 153. P.613-620.
9. Shaha A.R., Loree T.R., Shah J.P. Prognostic factors and risk group analysis in follicular carcinoma of the thyroid // Surgery. 1995. Vol.118. P.1131-1136; discussion 1136-1138.
10. Schults L.B., Chehab N.H., Malikzay A., Halazonetis T.D. p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks // J Cell Biol. 2000. Vol.151. P. 1381-1390.
11. Ward LM., Minn K., van Deursen J., Chen J. p53 Binding protein 53BP1 is reguired for DNA damage responses and tumor suppression in mice // Mol Cell Biol. 2003.Vol. 23. P.2556-2563.
Количество просмотров: 230
Библиографическая ссылка
Kozykenova Zh., Shalgimbayeva G.S., Mussazhanova Zh.B. Genomic instability in oncocytic follicular adenoma of the thyroid // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 4, pp. 133-136. doi 10.34689/SH.2022.24.4.017Похожие публикации:
ASSESSMENT OF RISK FACTORS FOR DEVELOPMENT OF URETHRAL STRICTURES AND BLADDER NECK SCLEROSIS IN PATIENTS WHO HAVE UNDERWENT SURGERY FOR BENIGN PROSTATE HYPERPLASIA
ТАБАННЫҢ ТАЙҚУЫН, ТОБЫҚ СЫНЫҚТАРЫНЫҢ ЖӘНЕ ЖІЛІК АРАЛЫҚ СИНДЕСМОЗ ДИАСТАЗЫН ОРНЫНА КЕЛТІРІП ТАБАНДЫ АСЫҚТЫ ЖІЛІККЕ БЕКІТУГЕ АРНАЛҒАН ҚҰРЫЛҒЫНЫ ҚОЛДАНУДАҒЫ КЛИНИКАЛЫҚ НӘТИЖЕЛЕРІ
РАЗРАБОТКА УСТРОЙСТВА ДЛЯ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ ПЕРЕЛОМОВ ПРОКСИМАЛЬНОГО ОТДЕЛА ПЛЕЧЕВОЙ КОСТИ. ПРОВЕДЕНИЕ БИОМЕХАНИЧЕСКОГО ЭКСПЕРИМЕНТА.
FREQUENCY AND ASSOCIATION OF THE FACTORS INFLUENCING FETAL GROWTH RESTRICTION IN THE REPUBLIC OF KAZAKHSTAN
ПРОБЛЕМНОЕ ИСПОЛЬЗОВАНИЕ СОЦИАЛЬНЫХ СЕТЕЙ И ПСИХОЛОГИЧЕСКОЕ БЛАГОПОЛУЧИЕ ГОРОДСКИХ И СЕЛЬСКИХ ПОДРОСТКОВ КАЗАХСТАНА