Online ISSN: 3007-0244,
Print ISSN:  2410-4280
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THE FREQUENCY OF POLYMORPHISMS OF THE GENE 5382insC BRCA1 IN PATIENTS WITH FAMILIAL BREAST CANCERS ARE EXPOSED TO IONIZING RADIATION AS A RESULT OF SEMIPALATINSK NUCLEAR TEST SITE AND THEIR DESCENDANTS
Genetic changes play an important role among the risk factors for breast cancer, but their mechanisms of and contribution to the development of the disease is not finalized.
Purpose of the study: determining the frequency of the BRCA1 gene polymorphism 5382insC in patients with familial breast cancers in the region radiological trouble Semipalatinsk nuclear test site in the first and second generations of irradiated.
Materials and methods: The study included 250 women aged 40 to 79 years, Kazakh nationality, including 190 breast cancer patients, distributed in groups. The first gro...
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2016 год | Выпуск: 3 | Страницы: 58-66

CLINICAL AND MORPHOLOGICAL FEATURES OF BREAST CANCER AMONG WOMEN WITH RADIOECOLOGICAL AND FAMILY ANAMNESIS
The peculiarities of histomorphological characteristics of malignant neoplasm can be linked to its genesis, including the presence of genetic changes in regulatory genes. By-turn, the frequency of the last depends from the influence of mutagenic factors.
The aim. The purpose of research is to determine the morphological features of breast cancer due to the presence of gene mutations BRCА1 and TP53 among women with family and radioecological anamnesis.
Materials and methods. The study included 190 women aged between 40 to 78 years, patients with breast cancer, ethnic Kazakhs, alloc...
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2016 год | Выпуск: 1 | Страницы: 66-76