THE FREQUENCY OF OCCURRENCE OF THYROID PATHOLOGY IN RESIDENTS OF THE TERRITORIES ADJACENT TO THE FORMER SEMIPALATINSK NUCLEAR TEST SITE
Introduction. The article provides an analysis of thyroid disease among the population of areas adjacent to the former Semipalatinsk nuclear test site. The tragic feature of the Semipalatinsk region, consisting in multiple acute and chronic exposure to large and small doses, virtually no area of decontamination and replacement foods have created a unique environment for the study of long-term exposure to certain doses of radiation on health. According to modern concepts, the main effects of exposure to radioactive iodine in the thyroid gland (TG) are thyroiditis, benign and malignant tumors. Among thyroid pathology observed a high frequency of autoimmune thyroiditis, and thyroid nodules (24,3% ± 0,81 - 28,3%±0,9). The study suggests the importance of radiation risk factor in the realization of thyroid pathology.
Objective: to study the frequency and features of thyroid gland and other endocrine diseases in residents of the territories adjacent to the former Semipalatinsk nuclear test site.
Materials and Methods: To study the epidemiological characteristics of thyroid pathology in the study region was carried out the cross-sectional study.
Conclusions: Given the set high frequency of autoimmune thyroiditis, the formation of nodules (24,3% ± 0,81 - 28,3% ± 0,9) and relatively high numbers prevalence among the surveyed population hypothyroidism (9,2% -42,1%), we can conclude the important role of ionizing radiation in the formation of thyroid disease in the population surveyed in the region. A more detailed study of the pathogenetic basis of the pathological effect of ionizing radiation on the state of the thyroid gland in the surveyed region will be possible with the molecular genetic analysis, which will provide early diagnosis and prevention of thyroid pathology in the study region.
Mayra Zh. Espenbetova1, http://orcid.org/0000-0003-2318-4765
Zhanar M. Zhumanbayeva1, http://orcid.org/0000-0001-8941-862X
Aynur S. Krykpayeva1, http://orcid.org/0000-0001-7701-9832
Zhanar K. Zamanbekova, http://orcid.org/0000-0003-3514-7144
Oksana A.Yurkovskaya, http://orcid.org/0000-0002-6251-5574
Kuralay Sh. Amrenova, http://orcid.org/0000-0002-4350-2698
Gulnar M. Shalgumbayeva, http://orcid.org/0000-0003-3310-4490
Natalia E.Glushkova, http://orcid.org/0000-0003-1400-8436
Semey State Medical University, Department of internship on general practice,
Semey, Republic of Kazakhstan
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Еспенбетова М.Ж., Жуманбаева Ж.М., Крыкпаева А.С., Заманбекова Ж.К., Юрковская О.А., Амренова К.Ш., Шалгумбаева Г.М., Глушкова Н.Е. Частота встречаемости патологии щитовидной железы у жителей территорий, прилегающих к бывшему Семипалатинскому испытательному ядерному полигону / / Наука и Здравоохранение. 2016. №6. С. 80-88. Espenbetova M.Zh., Zhumanbayeva Zh.M., Krykpayeva A.S., Zamanbekova Zh.K., Yurkovskaya O.A., Amrenova K.Sh., Shalgumbayeva G.M., Glushkova N.E. The frequency of occurrence of thyroid pathology in residents of the territories adjacent to the former Semipalatinsk nuclear test site. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 6, pp. 80-88. Еспенбетова М.Ж., Жуманбаева Ж.М., Крыкпаева А.С., Заманбекова Ж.К., Юрковская О.А., Амренова К.Ш., Шалгумбаева Г.М., Глушкова Н.Е. Бұрынғы Семей ядролық сынақ полигон аймағына жататын тұрғындардағы қалқанша без ауруының кездесу жиілігі / / Ғылым және Денсаулық сақтау. 2016. №6. Б. 80-88.Related publications:
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