Online ISSN: 3007-0244,
Print ISSN:  2410-4280
TREATMENT OF NON-OBSTRUCTIVE AZOOSPERMIA WITH MESENCHYMAL STEM CELLS. CLINICAL CASE.
Infertility in marital marriage is the most important medical and social problem, drawing the attention of many researchers to the problem of reproductive health of the population. The frequency of increasing infertility causes a decrease in the birth rate and a decrease in the population. According to statistics, about 20% of cases are associated with the male factor of infertility, 50% with the female factor. The male factor predominates in 50% of infertility cases. The article presents the results of our observation of a patient with non-obstructive azoospermia who received an intratesticular injection of mesenchymal stem cells. The results of our study, as well as the results of this review, should provide scientists, endrologists, reproductologists and healthcare managers with confidence that, according to the available scientific data, an innovative method of cell therapy is safe for clinical use. From a practical point of view, the results of this work can serve as the basis for the application of a new cellular approach for the treatment of this pathology using regenerative medicine.
Rano A. Zhankina1, Ulanbek Zhanbyrbekuly1, Amin Tamadon2, Manarbek B. Askarov3, Dana T. Saipieva3, Ravil T. Sherkhanov1, Daniyar E. Akhmetov1, Nurbol M. Keulimzhaev1 1Department of Urology and Andrology, NJSC "Astana Medical University", Nur-Sultan с., the Republic of Kazakhstan; 2Shiraz University of Medical Sciences, Shiraz, Iran; 3JSC "National Scientific Medical Center" Center for Cellular Technology, Transplantation and Scientific Management, Nur-Sultanс., the Republic of Kazakhstan.
1. Aboyan I.A., Grachev S.V., Pavlov S.V. et al. Structure and correlation of male infertility // Proceedings of the 8th Congress "Men's Health", Yerevan, 2012.P.10-19. 2. Agarwal A., Mulgund A., Hamada A., Chyatte M.R.A unique view on male infertility around the globe // ReprodBiolEndocrinol. 2015, Vol.26(4). P.13-3 3. Glybochko P.V., Alyaev Yu.G., Chaly M.E., Barashkov G.K. et al. Infertility and pathozoospermia after surgical treatment of varicocele // Farmateka. 2013. №3 (256). P. 35-37 4. Hendriks S., Dancet E.A., Meissner A. et al. Perspectives of infertile men on future stem cell treatments for nonobstructive azoospermia // Reproductive biomedicine online. 2014. V.28 (5). P. 650-657. 5. Kostin A.A., Kaprin A.D., Semin A.V., Kruglov D.P., Danielyan A.A. Infertility as an aspect of the quality of life of cancer patients //Oncourology. 2009. №4. P. 63-67 6. MetelevA.Yu., Bogdanov A.B., Ivkin E.V. et al. Prognostic value of various indicators of sperm in relation to male fertility // Andrology and Genital Surgery. 2015. T.16. No.4. P.51-54 7. Moazamian R., Polhemus A., Connaughton H. et al. Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation // Mol. Hum. Reprod. 2015. N. 21. P. 502–515. 8. Metelev A.Yu., Bogdanov A.B. et al. Prognostic value of various indicators of sperm in relation to male fertility // Andrology and Genital Surgery. 2015. T.16. No.4. P.51-54. 9. Shestakova O.V., Tetelyutina F.K. Quality of life and features of the psychoemotional state in a married couple with infertile marriage // Modern problems of science and education. 2015. No.6. P.146. 10. Vij S.C., Sabanegh E.Jr., Agarwal A. Biological therapy for non-obstructive azoospermia // Expert Opin Biol Ther. 2018. 18(1):19–23. 11. Cocuzza M., Alvarenga C., Pagani R. The epidemiology and etiology of azoospermia // Clinics, 2013. 68(Suppl 1), 15–26. 12. Hendriks S., Dancet E.F., Meissner A., van der Veen F., Mochtar M.H., Repping S. Perspectives of infertile men on future stem cell treatments for nonobstructive azoospermia // Reproductive Biomedicine Online, 2014. 28(5), 650–657. 13. Dabaja A.A., Schlegel P.N. Microdissection testicular sperm extraction: an update // Asian journal of andrology 2013. 15: 35–39. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid_3739122 & tool_pmcentrez&rendertype_abstract [Accessed April 5, 2014]. 14. Chiba K., Enatsu N., Fujisawa M. Management of non-obstructive azoospermia // Reprod Med Biol. 2016. 15:165-73. PMID: 29259433 DOI: 10.1007/s12522-016-0234-z. 15. Cyranoski D. Japan to offer fast-track approval path for stem cell therapies // Nat Med. 2013. 19:510.
Number of Views: 119

Key words:

Category of articles: Clinical case

Bibliography link

Zhankina R.A., Zhanbyrbekuly U., Tamadon A., Askarov M.B., Saipieva D.T., Sherkhanov R.T., Akhmetov D.E., Keulimzhaev N.M. Treatment of non-obstructive azoospermia with mesenchymal stem cells. Clinical case // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 4, pp. 240-245. doi 10.34689/SH.2022.24.4.029

Авторизируйтесь для отправки комментариев