FEATURES OF CHANGES IN HEMATOLOGICAL PARAMETERSOF BLOOD IN SYSTEMIC LUPUS ERYTHEMATOSUS.LITERATURE REVIEW

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with alternating multisystem and broad spectrum clinics. Any tissue in the body could be involved in SLE like musculoskeletal, cutaneous, renal, neurological, hematological, vascular, pulmonary, gastrointestinal and ocular. Hematological abnormalities are common
findings in patients with SLE. Sometimes, hematological abnormalities can be caused by the pathophysiology of SLE itself,
but at other times they can be found in patients with SLE but not be a manifestation of SLE. Thus, it is important to
distinguish hematological abnormalities as either manifestations of SLE, consequence of SLE treatment or as part of another
blood cell dyscrasia.
Objective: Review of current literature on the peculiarities of changes in hematological parameters of blood, the level of
white blood cells and white blood cell formulas depending on the activity and clinical manifestation of SLE disease.
Materials and methods: Search and analysis of material for writing articles were conducted on the information bases
and web sites PubMed, Scopus, Medline, Web of Science, SpringerLink, Web of Knowledge (Thomson Reuters), Medicine,
Science Direct, rheumatolog.ru, BMC (biomedcentral.com), cyberleninka.ru, BMJ (ard.bmj.com), Oxford academic
(academic.oup.com). The depth of search operations included data for the last 15-20 years. From more than 70 literary
sources, 63 were selected as analytical material for this article.
Results: Systemic lupus erythematosus (ICD-10) is an autoimmune disease of unknown etiology arising from genetic
disorders of the regulatory process immune system development of immune inflammation in the tissues of many organs,
education of special organisms of antibodies to core antigens and immune complexes of cells, with the development of
immune inflammation in the tissues of many organs.
Conclusion: Hematological disorders are the most common sign of the disease in patients with SLE. It is important to
distinguish between hematological disorders as a manifestation of SLE, the consequences of SLE treatment, or other types
of blood dyscrasia. Our review considered the pathogenesis of SLE, leukopenia, neutropenia, lymphocytopenia, and
peripheral cytopenia.