АTHEROGENESIS AND INFLAMMATION

Abstract

Introduction: The article presents atherosclerosis theory and modern views on the role of
inflammation in atherogenesis. We reviewed national and international literature on inflammatory theory
of atherosclerosis, the role of cytokines in the development of atherosclerosis, the interaction of the lipid
and inflammatory theory of atherogenesis, the formation of atherosclerotic plaque. Basic research in
molecular biology, immunology, genetics have greatly expanded the concept of the pathogenesis of
atherosclerosis.
The aim: Сonducting a literature review on the pathogenesis of atherosclerosis.

Materials and methods: We performed a systematic literature search in the online resources. We
found 300 sources, 68 of which were selected for the analysis. Key points of forming search queries for
the formation of the literature review were presented to the following elements: "atherosclerosis",
"inflammation", "cytokines", "atherogenesis."
Results: In the formation and destabilization of atherosclerotic plaques the main role can be
attributed to inflammation markers.
Conclusions: Inflammation has been actively involved in the implementation of the immune
response in atherosclerosis, in which the leading role played by intercellular interaction mediators -
cytokines, such as interleukin-6 and TNF-α. However, despite the large number of studies on the blood
inflammatory markers in atherosclerosis, to date there is no consensus on the nature and extent of the
inflammatory response in this disease.