CLINICAL AND MORPHOLOGICAL FEATURESOF BREAST CANCER AMONG WOMENWITH RADIOECOLOGICAL AND FAMILY ANAMNESIS

Abstract

The peculiarities of histomorphological characteristics of malignant neoplasm can be linked to its
genesis, including the presence of genetic changes in regulatory genes. By-turn, the frequency of the
last depends from the influence of mutagenic factors.
The aim. The purpose of research is to determine the morphological features of breast cancer due to
the presence of gene mutations BRCА1 and TP53 among women with family and radioecological
anamnesis.
Materials and methods. The study included 190 women aged between 40 to 78 years, patients with
breast cancer, ethnic Kazakhs, allocated to depending on the availability of family anamnesis of disease
and personal and family radioecological anamnesis.
The main group - women with breast cancer with the presence of a family history of malignant
tumor - 125 peoples. The main group was divided into 2 subgroups - with the presence of
radioecological anamnesis, including a family - 60 people, and without it - 65 people. As a comparison
group of 65 patients with breast cancer were examined, in which there was no family history of the
disease and information about irradiation. Time intervals inclusion in the study and prospective
observation in the groups were similar. The presence of mutations in BRCA1 and TP53 gene was
determined by PCR.
Result of the studys. Women with radioecological and family anamnesis were statistically
significant relative reduction in the incidence of infiltrating ductal cancer in the presence of BRCA1 and
TP53 gene mutations and combinations particularly by enhancing the role of such forms of cancer as
medullary cancer, secretory cancer, squamous cell carcinoma and tubular breast cancer.
Conclusions. In the study found presence of interconnection histological characteristics of breast
cancer with a family history and the presence of BRC1 and TP53 gene mutations. At persons with
mutant genotype of all clinical groups identified an increased frequency of relatively rare histological
forms of the disease. The first generation of a family history of breast cancer may also be due to the
action of radiation, since the majority of mothers in this group of women living in areas of the radiation
risk during the dose-forming explosions.