EFFECTIVENESS EVALUATION OF COMPREHENSIVETREATMENT OF PATIENTS WITH CHRONIC GENERALIZEDPERIODONTITIS ASSOCIATED WITH ORAL LICHENPLANUS BY MONITORING OF LOCAL IMMUNITY INDICES

Abstract

Relevance. Changes in the oral mucosa, parodontium tissues are in most cases clinical and
sometimes only signs of disorders in functioning of different organs and systems. Lichen planus is one
of the most wide-spread and manifest as for clinical implications diseases of the oral mucosa.
In this regard the goal of our research is assessment of sIgA in the oral fluid, C3 components of
the complement, activity of lysozyme and beta-lysins in patients suffering from CGP and lichen planus
before and after treatment, as indices of positive influence of suggested complex therapy on the
immunological course of CGP pathogenesis.
Object and methods of the research. 72 patients were examined and divided into 4 groups. The
first group (20 people) comprised patients with CGP of initial and mild severity without lichen planus. 32
patients with conjoint course of CGP (initial and mild severity) associated with planus (typical form) were
divided into 2 groups (2 and 3). The fourth observational group comprised patients with intact
parodontium (20 people).
Results of the research and their consideration. After conservative treatment firm increase of
lysozyme activity in the oral fluid of the patients of all observational groups after two weeks of treatment
and while control measurement of lysozyme intake in 3 months is noted. However, only in the patients,
who were undergoing treatment according to elaborated scheme, indices of lysozyme activity achieved
the level of control ones and corresponded to it during the whole period of observation (from 34,86% до
36,38%).
Conclusions. With reference to the foregoing it is possible to draw a conclusion that CGP as well as
conjoint course of CGP and lichen planus are accompanied by significant changes of local immunity of the
oral cavity which become apparent in the form of sharp decrease of lysozyme and beta-lysins activity,
reduction of the amount of C3 components of complement and increase sIgA level in the oral fluid.