DETECTION OF MUTATIONS IN RPOB GENE RESPONSIBLE FOR RIFAMPICIN-RESISTANCEAMONG CLINICAL ISOLATES OF M. TUBERCULOSIS FROM DIFFERENT REGIONS OF KAZAKHSTAN
DOI:
https://doi.org/10.34689/yt31v904Keywords:
rpoB gene , rifampicin-resistance , Mycobacterium tuberculosisAbstract
Spectrum of mutations in rpoB gene that cause resistance to one of the main antituberculosis drugs – rifampicin in clinical isolates of M. tuberculosis distributed in 3 regions (Almaty, Kostanay, Kyzylorda) of Kazakhstan was estimated in this
study. High frequency of mutation at codon Ser531 of rpoB gene (79,2%) responsible for drug resistance to rifampicin was
determined among M. tuberculosis population circulating in the mentioned regions.
References
А.Ж. Ахметова1, С.Е. Рахимова1, В.Л. Бисмилда2, М.А. Даришева3, А.Р. Акилжанова1 ОПРЕДЕЛЕНИЕ МУТАЦИЙ В RPOB ГЕНЕ, ОБУСЛАВЛИВАЮЩИХ УСТОЙЧИВОСТЬ К РИФАМПИЦИНУ СРЕДИ КЛИНИЧЕСКИХ ИЗОЛЯТОВ M. TUBERCULOSIS ИЗ РАЗЛИЧНЫХ ОБЛАСТЕЙ КАЗАХСТАНА //Наука и Здравоохранение 2014.№ 4. С. 26-27 А.Zh. Аkhmetova1, S.Е. Rakhimova1, V.L. Bismilda2, М.А. Darisheva3, A.R. Akilzhanova1 DETECTION OF MUTATIONS IN RPOB GENE RESPONSIBLE FOR RIFAMPICIN-RESISTANCE AMONG CLINICAL ISOLATES OF M. TUBERCULOSIS FROM DIFFERENT REGIONS OF KAZAKHSTAN // Nauka i Zdravookhranenie. 2014.№ 4. С. 26-27 А.Ж. Ахметова1, С.Е. Рахимова1, В.Л. Бісмілда2, М.А. Даришева3, А.Р. Ақылжанова1 ҚАЗАҚСТАННЫҢ ӘР ТҮРЛІ ОБЛЫСТАРЫНДА ТАРАЛҒАН M. TUBERCULOSIS ИЗОЛЯТТАРЫНЫҢ РИФАМПИЦИНГЕ ТӨЗІМДІЛІГІН АНЫҚТАЙТЫН RPOB ГЕНІНДЕ МУТАЦИЯЛАРДЫ АНЫҚТАУ // Ғылым және Денсаулық сақтау 2014.№ 4. С. 26-27
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Copyright (c) 2026 Айнур Ахметова, Сауле Рахимова, Венера Бисмилда, М.А. Даришева, А.Р. Акильжанова (Автор)
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