PREGRAVIDAL PREPARATION OF WOMENWITH ANTIPHOSPHOLIPID SYNDROME AND ITS RESULTS

Abstract

Systemic enzyme therapy and plasmapheresis is positioned as methods of pathogenetic treatment
of antiphospholipid syndrome. One manifestation of this syndrome is the habitual miscarriage.
Therefore, these approaches can be used in the preparation for pregnancy.

The purpose of research - assessment of the impact of systemic enzyme therapy on the functional
state of hemostasis in women with antiphospholipid syndrome in pregravidal preparation.
Materials and Methods: The study included 70 women of reproductive age with APS, verified by
clinical and laboratory methods studies. The age of women was between 23-35 years old (mean age
27,6 ± 1,3). The drug of systemic enzyme therapy (SET) Wobenzym in the dose of 5 tablets 3 times a
day for 1 month and 5-course intermittent plasmapheresis exfusions of 0.5-1.0 liters of plasma in 1 day
with the substitution of albumin have been appointed for 33 women of the main group. Repeated
courses SET and plasmapheresis are appointed by each month before the onset of pregnancy. The
dynamics of hemostasis and contents of interleukins in the peripheral blood were studied, as well as the
outcomes of pregnancy and childbirth.
Results: On the background in the use of complex methods of preparation by SET and
plasmapheresis was revealed a trend toward normalization of hemostasis, mainly due to vascular
platelet link. In addition, the use of the complex methods of treatment led to improve of parameters of
the immune status in pregnant women with APS, which indicates a significant decrease in the degree of
proinflammatory preparedness and immunocomplex pathology.
Among of 37 women of the comparison group, pregnancy was ended in birth by alive newborn only
in 9 cases - (24,3 ± 7,1)%. But, among of the 33 women from basic group there were 17 births by live
newborns - (51,5 ± 8,2)% (p <0,05).
In general, the use of this complex methods showed high efficiency on pathogenic mechanisms and
big clinical significance.