CLINICAL FEATURES OF HEPATOCELLULAR CARCINOMA

Abstract

Background. Hepatocellular carcinoma (HCC) is the most common primary malignant neoplasm of the liver. HCC is the
fifth most common cancer among men worldwide and seventh among women, and is the second leading cause of cancer
deaths in the world. In Kazakhstan HCC consistently ranks 10th in the structure of oncological diseases.
The aim of the research is to study the organizational and clinical features of providing care to patients with HCC at
National Scientific Center of Surgery named after A.N. Syzganov.
Materials and methods. Retrospective study. We studied inpatient records of patients diagnosed with HCC at National
Scientific Center of Surgery named after A.N. Syzganov from 2012 to 2020. It was processed in the statistical package IBM
SPSS Statistics 20. The following variables were used for the analysis: qualitative (history of diseases, stage of fibrosis) and
quantitative (age, duration of hospital stay, bilirubin level, body mass index).
Pearson’s chi-square test was applied to test for the difference. Chi-squared test was used to compare the categorical or
nominal variables. Differences were considered statistically significant when P ≤ 0.05. We assessed association between
continuous variables total bilirubin and BMI in patients with HCC using Correlation Analysis.
Results. According to the results of the study, 183 patients were treated at National Scientific Center of Surgery named
after A.N. Syzganov from 2012 to 2020 (ICD-10-C22.0). The average length of hospital stay was 12 bed-days. The average
age of patients with HCC was 61.67 ± 8.928 (95% CI: 59.84- 63.50). Among patients, the main reason for the development
of HCC was a history of hepatitis B, C, B with a delta agent. Patients with elevated bilirubin levels have a low body mass
index. Basically, in recent years, transarterial chemoembolization (TACE) is used in HCC at National Scientific Center of
Surgery named after A.N. Syzganov.
Conclusions. The average bed-days for the clinical-cost groups diagnosed with HCC for 2012-2020 was 12 bed-days at
National Scientific Center of Surgery named after A.N. Syzganov. The study revealed a correlation between BMI and the
level of bilirubin associated with the development of HCC and subsequent cell necrosis.