SUDDEN CARDIAC DEATH: ROLE OF GENETIC FACTORS
The prediction and prevention of SCD remains an enormous challenge. Despite the accumulation of remarkable insight into the genetic basis and regulation of cardiac excitability, translation of this knowledge into novel strategies to identify the majority of individuals at risk of SCD is lacking. Translating new genetic information into improved understanding of physiology and disease represents a bottleneck to progress in mechanistic SCD research. Recent population, clinical, and basic science research studies, however, suggest there are real opportunities to improve our ability to identify individuals at moderate and high risk of SCD and to intervene to diminish such risk. Nonetheless, the complexity of the problem cannot be overstated and integrative strategies spanning a broad range of scales from molecular through organism and population studies, will be required to make progress in area of SCD prophylaxis.
A.R. Akilzhanova1, Zh.M. Nurkina1, M.S. Bekbosynova2
1Center for Life sciences, Nazarbayev University, Astana
2National Scientific Cardio surgery Center, Astana
1. Максимов В. Н., Куликов И. В., Устинов С. Н., Иванова А. А., Новоселов В. П., Савченко С. В. Ассоци-ация полиморфизма гена SREBF2 с внезапной сердеч-ной смертью. //БЮЛЛЕТЕНЬ СО РАМН. - 2011. – Т. 31. № 5. – С. 14-18.
2. Бурякина Т. А., Затейщиков Д. А. Клинико-диагностические особенности кардиологического об-следования спортсменов. Трудный пациент. - 2011.- С 2-3
3. Katz A. M. Cardiac ion channels // N. Engl. J. Med. 1993. - 328. – P. 1244-1251.
4. Reuter H. et al. Properties of single calcium channels in cardiac cell culture// Nature. -1982. -Vol. 297. - Р. 501-540.
5. Brugada R. Role of molecular biology in identifying individuals at risk for sudden cardiac death // The American journal of cardiology. 2000. -V. 86 (9a). -Nov, 2. -P.28-33.
6. Мазур Н. А. Внезапная сердечная смерть // Рус. мед. журн. - 1995. 1. (6). - С. 7–9.
7. Schwartz P. J., La Rovere M. T., Vanoli E. Autonomic nervous system and sudden cardiac death // Circulation. 1992. 85. (Suppl. 1). – P. 177–191.
8. Westaway S. K., Reinier K., Huertas-Vazquez A., Evanado A., Teodorescu C., Navarro J., Sinner M. F., Gun-son K., Jui J., Spooner P., Kaab S. and Chugh S. S. Com-mon Variants in CASQ2, GPD1L, and NOS1AP Are Signifi-cantly Associated With Risk of Sudden Death in Patients With Coronary Artery Disease. CircCardiovasc Genet. -2011. - 4. - P. 397-402
9. Valdivia C. R., Ueda K, Ackerman M. J., Makielski J. C. GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A. Am J Physiol Heart Circ Physiol. - 2009. - 297: H1446–H1452
Number of Views: 236
Category of articles:
Articles
Bibliography link
А.Р. Акильжанова1, Ж.М. Нуркина1, М.С. Бекбосынова2 ВНЕЗАПНАЯ СЕРДЕЧНАЯ СМЕРТЬ: РОЛЬ ГЕНЕТИЧЕСКИХ ФАКТОРОВ. //НАУКА ЗДРАВООХРАНЕНИЕ 2012.№ 4. С. 10-13 A.R. Akilzhanova1, Zh.M. Nurkina1, M.S. Bekbosynova2 SUDDEN CARDIAC DEATH: ROLE OF GENETIC FACTORS. // NAUKA I DRAVOOKHRANENIE 2012.№ 4. С. 10-13 А.Р. Ақылжанова1, Ж.М. Нуркина1, М.С. Бекбосынова 2 ЖҮРЕК АУРУЫНАН КЕНЕТ ҚАЗА БОЛУЫ: ГЕНЕТИКАЛЫҚ ТҰРҒЫЛАРЫНЫҢ РОЛІ. // ҒЫЛЫМ ЖӘНЕ ЕНСАУЛЫҚ САҚТАУ. 2012.№ 4. С. 10-13Related publications:
THE DEMOGRAPHIC, CLINICAL AND SOCIAL CHARACTERISTICS OF PATIENTS WITH SCHIZOPHRENIA AND SCHIZOPHRENIA SPECTRUM DISORDERS
STUDY OF KOMPLAENTNOSTI FOR THERAPY OF PATIENTS WITH A HIGH CORONARY RISK
EARLY DIAGNOSIS OF METABOLIC SYNDROME IN CHILDREN AND TEENAGERS OF № 6 SCHOOL GYMNASIUM OF SEMEY
MONITORING OF EDUCATIONAL LEVEL OF DENTAL STUDENTS IN ORAL CAVITY HEALTH
СТОМАТОЛОГИЧЕСКИЙ СТАТУС ПАЦИЕНТОК НА ФОНЕ ПРИМЕНЕНИЯ СОПРОВОДИТЕЛЬНОЙ ТЕРАПИИ ПРИ ПРОВЕДЕНИИ ПРОТИВООПУХОЛЕВОЙ ХИМИОТЕРАПИИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ