CONTEMPORARY VIEWS ON ETIOLOGY AND RISK FACTORS FOR GASTRIC CANCER DEVELOPMENT. LITERATURE REVIEW
review presents the latest data on epidemiology and characterizes risk factors for the development of gastric cancer, such as the state of the environment, infectious agents, unhealthy dietary and lifestyle. The issues of genetic predisposition and screening practices are briefly reported.
Objectives: to present a review of literature data on etiology and leading risk factors for the development of gastric cancer.
Search strategy: search and analysis of scientific publications across the databases and web-resources PubMed, CochraneLibrary, Medscape (Medline), Globocan, ResearchGate, including CyberLeninka electronic library were performed. The depth of the search was 20 years, within 2000 - 2018, including the latest publications as of 2019. The review included sources according to their importance in evidence-based medicine: reports on randomized and cohort studies conducted on large populations (15); meta-analyzes (14) and systematic reviews (7). There were excluded: case-report articles, summaries of reports, personal messages and newspaper publications. A total of 119 publications were analyzed, of which 71 were included in this review.
Results: According to uptodate concepts, gastric cancer is a common multifactorial pathology, in the launch mechanism of which the leading roles are mostly being played by infection agents, disfavorable environment, unhealthy lifestyle and hereditary predisposition.
Conclusion: The role of a single factor in gastric cancer development is almost impossible to distinguish. The high-risk group consists of persons infected with H. pylori, with a burdened hereditary history, often with a low level of education and socio-economic status, committed to consuming unhealthy foods and living in ecologically unfavorable areas. Among people at high risk, screening is justified as clinically as economically.
Anar B. Tulyayeva1, https://orcid.org/0000-0001-7149-0121
Saule K. Balmagambetova1, https://orcid.org/0000-0003-4080-5383
Gaziza A. Smagulova2, https://orcid.org/0000-0001-7222-620x
Yerbolat M. Iztleuov3, https://orcid.org/0000-0002-5303-8593
Arip K. Koyshybaev1, https://orcid.org/0000-0002-6164-8009
Olzhas N. Urazayev1, https://orcid.org/0000-0003-4426-342Х
Marzhan A. Aitmagambetovа1, https://orcid.org/0000-0002-0346-5829
Azamat B. Zharylgapov1, https://orcid.org/0000-0003-1609-8519
Valery A. Toimanova1, https://orcid.org/0000-0002-2224-3789
1 The Department of Oncology and Visual Diagnosis, West Kazakhstan Medical University named after Marat Ospanov, Aktobe, Republic of Kazakhstan.
2 Vice-Rector for Clinical and Scientific Work, Marat Ospanov West Kazakhstan Medical University, Aktobe, Republic of Kazakhstan.
3 The course of visual diagnostics, West Kazakhstan Medical University named after Marat Ospanov, Aktobe, Republic of Kazakhstan.
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Tulyayeva A.B., Balmagambetova S.K., Smagulova G.A., Iztleuov Ye.M., Koyshybaev A.K., Urazayev O.N., Aitmagambetovа M.A., Zharylgapov A.B., Toimanova V.A. Contemporary views on etiology and risk factors for gastric cancer development. Literature review. Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 4, pp. 20-27.Related publications:
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