MICROBIOLOGICAL INDICATORS OF PATIENTS WITH CONFIRMED INFECTION COVID-19
Background. The aim of this study was to identify etiological microorganisms and antibiotic resistance rates of bacterial infection in patients with COVID-19 infection.
Materials and methods. A prospective microbiological study of the microbial landscape and antibiotic resistance of strains isolated from patients with confirmed COVID-19 infection, hospitalized in National Scientific Medical Research Center, Nur-Sultan, Kazakhstan. Identification of isolates and antibiotic susceptibility testing were performed by Vitek-2 automated system.
Results: During study period, 282 strains were isolated; of them, the most frequently isolated microorganisms were as follows: Streptococcus viridans group 51.6%, Candida sp. 24.8%, Acinetobacter baumannii 6.4% and Klebsiella pneumoniae 3.5% with high level of antibiotic resistance.
Conclusion. Based on our results, we report fungal and gram-negative bacterial infection with high level of antibiotic resistance in patients with COVID-19 infection. All this prompts the conduct of microbiological monitoring in order to make changes in the strategy of administration and treatment of these patients in accordance with the principles of the rational use of antimicrobial drugs.
Nelya M. Bissenova1, http://orcid.org/0000-0001-8722-0398
Aigerim S. Yergaliyeva1, http://orcid.org/0000-0003-2111-9888
1JSC National Scientific Medical Research Center, Laboratory of Microbiology,
Nur-Sultan, Republic of Kazakhstan
1. Priya Nori et al. Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge // Infect Contr and Hospital Epid, 2020. 1-5
2. MacIntyre C.R., Chughtai A.A., Barnes M., et al. The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a (H1N) // BMC Infect Dis. 2018.18:637.doi.org/10.1186/s12879-018-3548-0.
3. Morris D.E., Cleary D.W., Clarke S.C. Secondary bacterial infections associated with influenza pandemics // Front Microbiol 2017.8:1041
4. Mulcany M.E., McLoughlin R.M. Staphylococcus aureus and influenza A virus: patterns and coinfecrions. VBio. 2016. 7:e02068-16
5. Canning B., Sennyake R.V., Burns D., Moran E., Dedicoat M. Post-influenza aspergillus ventriculitis // Clin Infect Pract 2020:100026. doi:10.1016/j.clinpr.2020.100026
6. Guidelines of standards for microbiologic tests in the laboratory of clinical microbiology. National scientific medical research center, Astana, 2008.P.11-12
7. The European Committee on Antimicrobial Susceptibility Testing. Breakpoints tables for interpretation of MICs and zone diameters. 2018. Version 8.1.
8. Hughes S. et al. Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary care-setting // Clinical Micro and Infect 2020.(26).P.1395-99
9. Youngs J., Wyncoll D., Hopkins P., Arnold A., Ball J., Bicanic T. Improving antibiotic stewardship in COVID-19:Bacterial co-infection is less common than with inuenza // J Infect 2020.81(3):55-57
10. Timothy M.R., Luke S.P., Nina Zhu, et al. Bacterial and fungal coinfection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing // Clinical Infectious Diseases. doi.org/10.1093/cid/ciaa530
11. Verroken A., Scohy A., Gerard L., et al. Co-infections in COVID-19 critically ill and antibiotic management: A prospective cohort analysis // Crit Care. 2020.24:410. doi.org/10.1186/s13054-020-03135-7
12. Hans H. Liu et al. Bacterial and fungal growth in sputum cultures from 165 COVID-19 pneumonia patients requiring intubation: evidence for antimicrobial resistance development and analysis of risk factors. doi:10.21203/rs.3.rs-79487/v1
13. Zhou P., Liu Z., Chen Y., et al. Bacterial and fungal infections in COVID-19 patients: A matter of concern // Infect Control Hosp Epidemiology. 2020. doi:10.1017/ice.2020.156.
14. Cheng B., Hu J., Zuo X., et al. Predictors of progression from moderate to severe coronavirus disease 2019: A retrospective cohort // Clin Micro Infect. 2020. doi.org/10.1016/j.cmi.2020.06.033.
Number of Views: 217
Category of articles:
COVID-19 - Topical Subject
Bibliography link
Bissenova N.M., Yergaliyeva A.S. Microbiological indicators of patients with confirmed infection COVID-19 // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, 6 (Vol.22), pp. 5-10. doi 10.34689/SH.2020.22.6.001Related publications:
IMMUNOLOGICAL CHANGES IN CHILDREN WITH MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH SARS-COV-2
EFFICACY OF THE ANTIVIRAL DRUG ENISAMY IODIDE IN SEVERE ADULT ACUTE RESPIRATORY INFECTIONS IN THE COVID-19 ERA
APPLICATION OF ARTIFICIAL INTELLIGENCE IN COMBATING THE COVID-19 PANDEMIC: CURRENT TRENDS AND PROSPECTS. REVIEW
CONSEQUENCES OF THE CORONAVIRUS INFECTION: THE POST-COVID SYNDROME AND MENTAL MANIFESTATIONS. LITERATURE REVIEW
FEATURES OF THE SICKNESS BEHAVIOR OF ARTERIAL HYPERTENSION AND OBESITY DURING THE PANDEMIC OF COVID-19 CORONAVIRUS. REVIEW