POEMS SYNDROME: CLINICAL CASE. AUTOLOGICAL TRANSPLANTATION OF PERIPHERAL HEMATOPOIETIC STEM CELLS AS AN EFFECTIVE THERAPEUTIC TREATMENT OPTION.
Introduction. POEMS is a rare multisystem paraneoplastic syndrome, secondary to plasma cell dyscrasia, accompanied by symptoms and/or signs of peripheral polyneuropathy (P), osteosclerotic lesions, Castleman's disease, organomegaly (O), endocrinopathy (E), serum monoclonal protein (M) edema, typical changes in the skin (S), optic and/or nerve disc edema, serum VEGF (vascular endothelial growth factor) level elevation. Despite the insignificant level of monoclonal secretion in comparison with multiple myeloma, the treatment of POEMS syndrome is carried out according to a similar protocol. High-dose chemotherapy with subsequent transplantation of peripheral stem cells is considered the most effective. Here we present a patient with POEMS syndrome who achieved a rapid complete response to double therapy consisting of systemic chemotherapy followed by autologous transplantation of hematopoietic stem cells.
Case description. A 56-year-old man presented with generalized edema syndrome, significant weight loss, and progressive weakness in lower extremities. A vivid clinical picture practically excluded other diagnostic alternatives, and a diagnosis of POEMS syndrome was made. After systemic chemotherapy and autologous hematopoietic stem cell transplantation, a complete hematological response was achieved, and the patient showed clinical recovery.
Conclusion. High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is an effective therapy for young age patients with POEMS syndrome.
Olga O. Kolesnikova1, Vadim M. Kemaykin1, Azat B. Karabekov1,
Ruzal F. Vildanova1, Ayagul M. Ainabai1
“National Research Oncology Center” LLP, Nur-Sultan, Republic of Kazakhstan.
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Kolesnikova O.O., Kemaykin V.M., Karabekov A.B., Vildanova R.F., Ainabai A.M. POEMS syndrome: clinical case. Autological transplantation of peripheral hematopoietic stem cells as an effective therapeutic treatment option // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 6, pp. 224-229. doi 10.34689/SH.2021.23.6.024Related publications:
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