ГЕНЕТИЧЕСКИЕ АССОЦИАЦИИ С ПРЕДРАСПОЛОЖЕННОСТЬЮ К РЕВМАТОИДНОМУ АРТРИТУ. ОБЗОР ЛИТЕРАТУРЫ.
Введение: Ревматоидный артрит (РА) характеризуется аутоиммунным воспалением, поражающим суставы и весь организм. Распространенность РА в мире составляет 0,5-1%, однако этот показатель варьируется в зависимости от географических регионов. Этиология РА до сих пор неизвестна. Взаимосвязь между эндогенными и экзогенными факторами подтверждается рядом исследований. Одним из виновников развития ревматоидного артрита и ведущих эндогенных факторов является генетическая предрасположенность, которая является широким предметом изучения на сегодняшний день.
Цель: продемонстрировать актуальность темы изучения генетических ассоциаций с предрасположенностью к ревматоидному артриту научно-практическому медицинскому сообществу Казахстана.
Cтратегия поиска: Представленная обзорная статья написана в рамках исследования по проекту АР08052703 «Определение микробиомных и геномных биомаркеров ревматоидного артрита в Казахстанской популяции». Информационный поиск осуществлялся в базах данных PubMed, Trip Database, EMBASE, Medline, Elsiever, GoogleScholar. В общей сложности было найдено 206 литературных источников, 100 из которых соответствовали критериям отбора и были включены в этот обзор. Критерии включения: полнотекстовые статьи, опубликованные на английском и русском языках в основном за последние 5 лет. Однако для подробного описания базовых знаний и механизмов также использовались более ранние источники. Критерии исключения: неподходящие источники, неполные статьи, дубликаты, рефераты.
Результаты и выводы: на сегодняшний день изучены более 100 локусов HLA и неHLA генов РА. В этой статье мы попытались сосредоточиться на наиболее широко изученных или патогенетически ведущих генах, связанных с высоким риском развития РА. Изучение генетической предрасположенности к РА, безусловно, требует дальнейших обширных исследований. Со своей стороны, мы надеемся, что наша работа дополнит данные о патогенезе РА и роли генетических маркеров в развитии этой патологии.
*Аргуль А. Исильбаева1,2,
Баян А. Айнабекова2
1 Назарбаев университет, Лаборатория микробиома и долголетия человека, Центр наук о жизни, Национальная лаборатория Астана, г. Нур-Султан, Республика Казахстан;
2 НАО "Медицинский университет Астана", Кафедра внутренних болезней с курсом гастроэнтерологии, эндокринологии и пульмонологии, г. Нур-Султан, Республика Казахстан.
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Исильбаева А.А., Айнабекова Б.А. Генетические ассоциации с предрасположенностью к ревматоидному артриту. Обзор литературы // Наука и Здравоохранение. 2022. 1 (Т.24). С. 139-146. doi: 10.34689/SH.2022.24.1.016Related publications:
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