CLINICAL AND DIAGNOSTIC FEATURES OF THE COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN PATIENTS TREATED IN AN INFECTIOUS HOSPITAL IN SEMEY
Introduction. Over the past years, the object of close study of many researchers is coronavirus infection. The infection under study may have both asymptomatic or mild and pronounced clinical course with the development of community-acquired pneumonia.
Objective: Study of clinical and diagnostic features of COVID-19-associated pneumonia in patients treated in the infectious diseases hospital of Semey.
Methods: A retrospective analysis of the data of discharge epicrises of 70 patients with a confirmed diagnosis of COVID-19-associated pneumonia was carried out. The sex and age structure, clinical symptoms, premorbid background, laboratory and instrumental data were analyzed.
Results: The study showed that the main clinical symptoms of COVID-19-associated pneumonia are weakness, cough, shortness of breath, fever. Concomitant somatic pathology included hypertension, coronary heart disease, diabetes mellitus, chronic obstructive pulmonary disease, oncological pathology. Laboratory assessments at the time of hospitalization showed an increase in white blood cell (62.9%) and ESR (52.9%), a decrease in lymphocyte count (37.1%), an increase in C-reactive protein (90%), alanine aminotransferase (65.7%), and aspartate aminotransferase (45.7%). With the progression of pneumonia severity, the level of C-reactive protein increased, while statistically significant differences in the level of C-reactive protein were found depending on the severity of the disease (р˂0,001). According to computed tomography of the chest and mediastinal organs, the main diagnostic criteria for COVID-19-associated pneumonia were bilateral polysegmental damage to the lung tissue in the form of areas of infiltrative darkening of the "ground-glass" type, which have a tendency to consolidate in severe form of the disease.
Conclusions: The clinical picture in COVID-19-associated pneumonia is characterized by non-specific clinical manifestations with a dominant predominance of respiratory symptoms in the form of shortness of breath and cough, as well as hyperthermia and weakness. Diagnostic significance is the increase in C-reactive protein, the level of which increases as the disease progresses, and the presence of infiltrative darkening sites on computer tomograms of the lungs, which have a tendency to consolidate in severe pneumonia.
Darkhan M. Kairalinov1, https://orcid.org/0000-0002-9906-0075
Aigul M. Tokesheva2, https://orcid.org/0000-0003-0651-7943
Ardak N. Zhumagalieva2, https://orcid.org/0000-0003-2128-6207
Asem K. Musainova2, https://orcid.org/0000-0002-0243-0456
Zhanara B. Ibrayeva2, https://orcid.org/0000-0001-7298-7869
Zarina K. Nuralina2, https://orcid.org/0000-0001-9390-4794
1 Polyclinic No. 1 of Semey с., Semey с., Republic of Kazakhstan;
2 NCJSC «Semey Medical University», Semey c., Republic of Kazakhstan.
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Bibliography link
Kairalinov D.M., Tokesheva A.M., Zhumagalieva A.N., Musainova A.K., Ibrayeva Zh.B., Nuralina Z.K. Clinical and diagnostic features of the course of COVID-19-associated pneumonia in patients treated in an infectious hospital in Semey // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 5, pp. 52-59. doi 10.34689/SH.2022.24.5.007Related publications:
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