A CASE OF FATAL ACUTE NECROTISING ENCEPHALOPATHY ASSOCIATED WITH PROBABLE SARS-CoV-2
Introduction. Clinical studies during the epidemic of a new coronavirus infection caused by the SARS-CoV-2 virus confirm not only neurotropic damage to the central nervous system, but also complex immune-mediated neurological complications of COVID 19, one of which is acute necrotizing encephalopathy.
Purpose of the study. Presentation of a clinical case of acute fatal necrotizing encephalopathy resulting from a severe respiratory infection probably caused by the SARS-CoV-2 virus.
Research methods. Retrospective analysis of the medical history, interpretation of clinical and laboratory data, neuroimaging studies and autopsy results in a 22-year-old patient with a fatal neurological complication of a respiratory infection that occurs with bilateral polysegmental interstitial pneumonia.
Сonclusions. Characteristic ground-glass lung changes suggested a new coronavirus infection caused by the SARS-CoV-2 virus, despite a negative PCR result for virus RNA in a nasopharyngeal and cerebrospinal fluid swab. The rapid increase in focal and cerebral neurological symptoms, diffuse changes and edema of the brain substance according to CT scan and subsequently according to the results of autopsy, signs of systemic inflammation and changes in the coagulating blood system confirmed the changes characteristic of the "cytokine storm" and DIC syndrome developing against the background of systemic endothelitis in COVID 19.
Dinara S. Alzhanova1, https://orcid.org/0000-0003-2674-6778
Aliya А. Imanova2, https://orcid.org/0000-0002-4668-8467
Fariza M. Sadykova 2, https://orcid.org/0000-0003-4183-6085
Elvira Zh. Tanirkhanova2, https://orcid.org/0000-0002-7127-6341
1 NJSC «Astana Medical University», Nur-Sultan, Republic of Kazakhstan;
2 Multifunctional Сity Hospital №2, Nur-Sultan, Republic of Kazakhstan.
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Alzhanova D.S., Imanova A.A., Sadykova F.M., Tanirkhanova E.Zh. A case of fatal acute necrotising encephalopathy associated with probable SARS-CoV-2 // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 6, pp. 13-19. doi 10.34689/SH.2022.24.6.002Related publications:
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