Online ISSN: 3007-0244,
Print ISSN:  2410-4280
THE CURRENT STATE OF THE PROBLEM OF THE FORMATION AND DYNAMICS OF THE INFANTS' MICROBIOTA. LITERATURE REVIEW
Relevance: The human's microbiome is a complex and dynamic ecosystem. It plays an important role in the metabolism and physiology of the individual. Research shows a critical relationship between the human microbiome and individual's metabolism. The interaction between the microbiome and human's metabolism affects human health and disease. The more researches are needed with the usage of new technologies for better understanding the formation of the microbiota. The Aim: General characteristics of modern information about the trajectories of the formation of the microbiome of infants. Search strategy: The search for publicly available scientific publications was carried out using the following databases of scientific publications and specialized search engines: PubMed, Google Scholar, Web of Science, Сyberleninca. A number of original publications and reviews in the field of research over the past 10 years have been analyzed. As a result of the search, we studied 1695 foreign and russian-language publications, of which 78 publications were included in this review. Inclusion сriteria: Evidence level A, B publications: meta-analyses, systematic reviews, cohort and cross-sectional studies. Exclusion criteria: short reports, newspaper articles and expert opinion in the form of short messages. Results and conclusions: We have analyzed current data on the infant's gut microbiome and assessed the impact of delivery and feeding patterns on its development. Unlike infants born vaginally, the gut microbiota of infants born by caesarean section showed significantly less similarity to their maternal microbiome. The type of feeding (natural or artificial), as well as the introduction of complementary foods into the diet of infants, has a significant impact on the composition and functions of the microbiota in the early stages. The composition of the microbiota and the ecological network had distinctive features influenced by the social determinants of health. These results form the basis for understanding the interaction between the gut's microbiome and the human's body at an early age.
Zarina K. Meiirmanova1, https://orcid.org/0000-0002-4997-6704 Marina A. Morenko1, https://orcid.org/0000-0001-9553-3560 Kseniya V. Shnaider1, https://orcid.org/0000-0002-4919-1878 Bakytkul Zh. Toktabayeva2, https://orcid.org/0000-0001-5899-1247 Samat S. Kozhakhmetov3, https://orcid.org/0000-0001-9668-0327 Irina N. Zakharova4, Arailym K. Duysebaeva1, https://orcid.org/0000-0003-4249-7652 Madina R. Gatauova1, https://orcid.org/0000-0002-6517-192X 1NJSC "Astana Medical University", Astana, Republic of Kazakhstan; 2NJSC "Semey Medical University", Semey, Republic of Kazakhstan; 3. "Center for Life Sciences", "Nazarbayev University", Astana, Republic of Kazakhstan; 4. Department of Pediatrics named after academician G.N. Speransky, «National Medical Research Center for Children's Health», Moscow, Russian Federation.
1. Антонова Л.К., Самоукина А.М., Алексеева Ю.А., Федотова Т.А., Петрова О.А., Страхова С.С. Современный взгляд на формирование микробиоты пищеварительного тракта у детей первого года жизни // Современные проблемы науки и образования. 2018. №6. С. 115-122. 2. Aagaard K., Jun Ma, Kathleen M. Antony et al. The placenta harbors a unique microbiome // Comparative Study Sci Transl Med. 2014. May 21. 6 (237):237ra65. 3. Al-Balawi M., Morsy F.M. Enterococcus faecalis. Is a Better Competitor Than Other Lactic Acid Bacteria in the Initial Colonization of Colon of Healthy Newborn Babies at First Week of Their Life // Front Microbiol. 2020. 11:2017. 4. Aloisio I., Quagliariello A., De Fanti S. et al. Evaluation of the effects of intrapartum antibiotic prophylaxis on newborn intestinal microbiota using a sequencing approach targeted to multi hypervariable 16S rDNA regions // Appl Microbiol Biotechnol, 2016. 100 (12): p. 5537–5546. 5. Arslanoglu S., Moro G.E., Boehm G., Wienz F., Stahl B., Bertino E. Early neutral prebiotic oligosaccharide supplementation reduces the incidence of some allergic manifestations in the first 5 years of life // J. Biol. Regul. Homeost. Agents. 2013. 26:49–59. 6. Azad M.B., Konya T., Maughan H., et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity // Allergy Asthma Clin Immunol, 2013. 9(1): p. 15. 7. Bagga R., Arora P. Genital microorganisms in pregnancy // Front. Public Health. 2020. (8):225. 8. Backhed F., Roswall J., Peng Y. et al. Dynamics and stabilization of the human gut microbiome during the first year of life // Cell Host Microbe. 2015; 17(6): 852. 9. Backhed F., Roswall J., Peng Y., Feng Q., Jia H., Kovatcheva-Datchary P., Li Y., Xia Y., Xie H., Zhong H., et al. Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life // Cell Host Microbe. 2015; 17: 690–703. 10. Bezirtzoglou E., Stavropoulou E. Immunology and probiotic impact of the newborn and young children intestinal microflora // Anaerobe. 2013; 17 (6): 369–374. 11. Bergstrom A., Skov T.H., Bahl M.I., Roager H.M., Christensen L.B., Ejlerskov K.T., Molgaard C., Michaelsen K.F., Licht T.R. Establishment of intestinal microbiota during early life: A longitudinal, explorative study of a large cohort of Danish infants // Appl. Environ. Microbiol. 2014; 80: 2889–2900. 12. Bernstein C.N., Burchill C., Targownik L.E., Singh H., Roos L.L. Events Within the First Year of Life, but Not the Neonatal Period, Affect Risk for Later Development of Inflammatory Bowel Diseases // Gastroenterology. 2019. 156: 2190–2197.e10. 13. Bischoff S.C., Boirie Y., Cederholm T. et al. Towards a multidisciplinary approach to understand and manage obesity and related diseases // Clin Nutr. 2017. 36(4):917–938. 14. Borewicz K., Suarez-Diez M., Hechler C., Beijers R., de Weerth C. et al. The effect of prebiotic fortified infant formulas on microbiota composition and dynamics in early life // Sci. Rep. 2019. 9:2434. 15. Cabrera-Rubio R., Collado M.C., Laitinen K., Salminen S., Isolauri E., Mira A. The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery // Am. J. Clin. Nutr. 2013. 96:544–551. 16. Cho I., Blaser M.J. The human microbiome: at the interface of health and disease // Nat. Rev. Genet. 2012. 13:260–270. 17. Chu D.M., Ma J., Prince A.L., Antony K.M., Seferovic M.D., Aagaard K.M. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery // Nat Med. 2017. 23:314–26. 18. Chu D.M., Ma J., Prince A.L., Antony K.M., Seferovic M.D., Aagaard K.M. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery // Nat. Med. 2017. 23:314–326. 19. Cheng J., Ringel-Kulka T., Heikamp-de Jong I., Ringel Y., Carroll I., de Vos W.M., Salojärvi J., Satokari R. Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children // ISME J. 2016. 10:1002–1014. 20. Costello E.K., Carlisle E.M., Bik E.M., Morowitz M.J., Relman D.A. Microbiome assembly across multiple body sites in low-birthweight infants // MBio. 2013. 4, e00782–13. 21. De Filippo C., Cavalieri D., Di Paola M. et al. Effects of diet on gut microbiota formation from a comparative study in children from Europe and rural Africa // Proc Natl Acad Sci USA. 2013. 107(33): 14691-14696. 22.De Filippo C., Cavalieri D., Di Paola M., Ramazzotti M., Poullet J.B., Massart S., Collini S., Pieraccini G., Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa // Proc. Natl. Acad. Sci. USA. 2013. 107:14691–14696. 23. Dominguez-Bello M.G., Costello E.C., Contreras M., Magris M., Hidalgo G., Fierer N., Knight R. The method of delivery determines the acquisition and structure of the initial microbiota in different habitats of newborns // Proc Natl Acad Sci USA. 2013 June 29. 107(26):11971-5. 24. Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns// Proc Natl Acad Sci USA. 2013. 107(26):11971–11975. 25. Findley K., Oh J., Yang J., Conlan S., Deming C., Meyer J.A., et al. Topographic diversity of fungal and bacterial communities in human skin // Nature. 2013. 498: 367–70. 26. Forbes J.D., Azad M.B., Weling L. et al. Association of hospital formula exposure and subsequent feeding practices in infants with gut microbiota and risk of overweight in the first year of life // JAMA Pediatr. 2018. 172(7):el81161. 27. Friedman E.S., Bittinger K., Esipova T.V. et al. Microbes vs. chemistry in the origin of the anaerobic gut lumen // Proc Natl Acad Sci USA. 2018. 115(16):4170–4175. 28. Fukuda S., Toh H., Hase K., Oshima K., Nakanishi Y., Yoshimura K., Tobe T., Clarke J.M., Topping D.L., Suzuki T., et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate // Nature. 2013. 469:543–547. 29. Gomez-Arango L.F. et al. Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women // Sci. Rep. 2017. 7:2860. 30. Gomez-Gallego C., Garcia-Mantrana I., Salminen S., Collado M.C. The human milk microbiome and factors influencing its composition and activity // Semin. Fetal Neonatal Med. 2016. 21:400–405. 31. Guo S., Gillingham T., Guo Y., Meng D., Zhu W., Walker W.A., Ganguli K. Secretions of Bifidobacterium infantis and Lactobacillus acidophilus Protect Intestinal Epithelial Barrier Function // J. Pediatr. Gastroenterol. Nutr. 2017. 64:404–412. 32. Hascoët J.M., Hubert C., Rochat F., Legagneur H., Gaga S., Emady-Azar S., Steenhout P.G. Effect of formula composition on the development of infant gut microbiota // J. Pediatric Gastroenterol. Nutr. 2013; 52:756–762. 33. Hermansson H., Kumar H., Collado M.C., Salminen S., Isolauri E., Rautava S. Breast Milk Microbiota Is Shaped by Mode of Delivery and Intrapartum Antibiotic Exposure // Front Nutr. 2019. 6:4. 34. Hollister E.B., Riehle K., Luna R.A., Weidler E.M., Rubio-Gonzales M., Mistretta T.A., Raza S., Doddapaneni H.V., Metcalf G.A., Muzny D.M., et al. Structure and function of the healthy pre-adolescent pediatric gut microbiome // Microbiome. 2015. 3:36. 35. Human Microbiome Project C Structure, function and diversity of the healthy human microbiome // Nature. 2013. 486:207–14. 36. Jirillo E., Jirillo F., Magrone T. Healthy effects exerted by prebiotics, probiotics, and symbiotics with special reference to their impact on the immune system // Int. J. Vitam. Nutr. Res. 2013. 82 (3): 200–208. 37. Jo J.H., Deming C., Kennedy E.A., Conlan S., Polley E.C., Ng W.L. et al. Diverse human skin fungal communities in children converge in adulthood // J Invest Dermatol. 2016. 136:2356–63. 38. Jost T., Lacroix C., Braegger C.P., Rochat F., Chassard C. Vertical mother–neonate transfer of maternal gut bacteria via breastfeeding // Environ. Microbiol. 2014. 16:2891–2904. 39. Kennedy E.A., Connolly J., Hourihane J.O., Fallon P.G., and McLean W.H., and Murray D., et al. Skin microbiome before development of atopic dermatitis: early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year // J Allergy Clin Immunol. 2017. 139: 166–72. 40. Kim G., Bae J., Kim M.J. et al. Delayed Establishment of Gut Microbiota in Infants Delivered by Cesarean Section // Front Microbiol. 2020. 11:2099. 41. Koenig J.E., Spor A., Scalfone N., et al. Succession of microbial consortia in the developing infant gut microbiome // Proc Natl Acad Sci USA, 2013. 108. Suppl 1:4578–85. 42. Kong H.H., Segre J.A. The molecular revolution in cutaneous biology: investigating the skin microbiome // J Invest Dermatol. 2017. 137: e119–22. 43. Kumar H., du Toit E., Kulkarni A., Aakko J., Linderborg K.M., Zhang Y., Nicol M.P., Isolauri E., Yang B., Collado M.C., et al. Distinct Patterns in Human Milk Microbiota and Fatty Acid Profiles Across Specific Geographic Locations // Front. Microbiol. 2016. 7:1619. 44. Laursen M.F., Bahl M.I., Michaelsen K.F., Licht T.R. First Foods and Gut Microbes // Front. Microbiol. 2017. 8:356. 45.Laursen M.F., Andersen L.B.B., Michaelsen K.F., Mølgaard C., Trolle E., Bahl M.I., Licht T.R. Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity // mSphere. 2016; 1: e00069-15. 46. Laursen M.F., Zachariassen G., Bahl M.I. et al. Having older siblings is associated with gut microbiota development during early childhood // BMC Microbiol, 2015; 15:154. 47. Le Doare K., Holder B., Bassett A., Pannaraj P.S. Mother’s milk: A purposeful contribution to the development of the infant microbiota and immunity // Front. Immunol. 2018. 9:361. 48. Levin A.M., Sitarik A.R., Havstad S.L., Fujimura K.E., Wegienka G., Cassidy-Bushrow A.E., Kim H., Zoratti E.M., Lukacs N.W., Boushey H.A., et al. Joint effects of pregnancy, sociocultural, and environmental factors on early life gut microbiome structure and diversity // Sci. Rep. 2016. 6:31775. 49. Lihong Zhu, Fei Luo, Wenjing Hu, et al. Bacterial communities in the womb during healthy pregnancy // Front Microbiol. 2018. (9):2163. 50. Martin V., Maldonado-Barragan A., Moles L., Rodriguez-Banos M., Campo R.D., Fernandez L., Rodriguez J.M., Jimenez E. Sharing of bacterial strains between breast milk and infant feces // J. Hum. Lact. Off. J. Int. Lact. Consult. Assoc. 2013; 28:36–44. 51. Martín R., Jiménez E., Heilig H., Fernández L., Marín M.L., Zoetendal E.G., Rodríguez J.M. Isolation of Bifidobacteria from Breast Milk and Assessment of the Bifidobacterial Population by PCR-Denaturing Gradient Gel Electrophoresis and Quantitative Real-Time PCR. Appl. Environ// Microbiol. 2009. 75:965. 52. Martin R, Makino H, Cetinyurek Yavuz A, et al. Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota // PLoS One. 2016. 11:e0158498. 53. Ma J., Li Z., Zhang W., Zhang C., Zhang Y., Mei H., Zhuo N., Wang H., Wang L., Wu D. Comparison of gut microbiota in exclusively breast-fed and formula-fed babies: A study of 91 term infants // Sci. Rep. 2020;10:15792. 54. Mitchell C.M., Mazzoni C., Hogstrom L., Bryant A., Bergerat A., Cher A., Pochan S., Herman P., Carrigan M., Sharp K., et al. Delivery Mode Affects Stability of Early Infant Gut Microbiota // Cell Rep. Med. 2020. 1:100156. 55. Milani C., Duranti S., Bottacini F., Casey E., Turroni F., Mahony J., Belzer C., Delgado Palacio S., Arboleya Montes S., Mancabelli L., et al. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota // Microbiol. Mol. Biol. Rev. 2017. 81: e00036-17. 56. Moya-Pérez A., Luczynski P., Renes B.I., Wang Sh. Intervention strategies for cesarean section-induced alterations in the microbiota-gut-brain axis // Nutr Rev. 2017 Apr 1. 75(4):225-240. 57. Muriel Derrien, Anne-Sophie Alvarez, Willem M de Vos The Gut Microbiota in the First Decade of Life // PMID:31474424 58. Nagpal R., Tsuji H., Takahashi T., et al. Ontogenesis of the Gut Microbiota Composition in Healthy, Full-Term, Vaginally Born and Breast-Fed Infants over the First 3 Years of Life: A Quantitative Bird’s-Eye View // Front Microbiol. 2017; 8:1388. 59. Nermes M, Endo A, Aarnio J, et al., Furry pets modulate gut microbiota composition in infants at risk for allergic disease // J Allergy Clin Immunol, 2015. 136(6): p. 1688–1690.e1681. 60. Pichler M.J., Yamada C., Shuoker B., Alvarez-Silva C., Gotoh A., Leth M.L., Schoof E., Katoh T., Sakanaka M., et al. Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways // Nat. Commun. 2020. 11:3285. 61. Pompei A., Cordisco L., Amaretti A., Zanoni S., Matteuzzi D., Rossi M. Folate Production by Bifidobacteria as a Potential Probiotic Property // Appl. Environ. Microbiol. 2013. 73:179. 62. Prince A.L., Ma J., Kannan P.S. et al. The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis // Am J Obstet Gynecol. 2016 214(5): 627.e1–627. e16. 63. Qasem W., Azad M.B., Hossain Z., Azad E., Jorgensen S., Castillo San Juan S., Cai C., Khafipour E., Beta T., Roberts L.J., et al. Assessment of complementary feeding of Canadian infants: Effects on microbiome & oxidative stress, a randomized controlled trial // BMC Pediatr. 2017. 17:54. 64. Rautava S. Microbial Composition of the Initial Colonization of Newborns // Nestle Nutr Inst Workshop Ser. 2017. 88:11–21. 65. Reyman M., van Houten M.A., van Baarle D., Bosch A.A.T.M., Man W.H., Chu M.L.J.N., Arp K., Watson R.L., Sanders E.A.M., Fuentes S., et al. Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life // Nat. Commun. 2019. 10:4997. 66. Reyman M., Houten M., Watson R., Ling M.J. Kayleigh Arp et al ., Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial // Nature Communications 2022 Feb 16;13(1):893. 67. Ringel-Kulka T., Cheng J., Ringel Y., Salojärvi J., Carroll I., Palva A., de Vos W.M., Satokari R. Intestinal Microbiota in Healthy U.S. Young Children and Adults - A High Throughput Microarray Analysis // PLoS ONE. 2013. 8: e64315. 68. Roberfroid M.B. Prebiotics and probiotics: are they functional foods? // Am. J. Clin. Nutr. 2000. 71 (6) Suppl.: 1682–1687. 69. Shi B., Bangayan N.J., Curd E., Taylor P.A., Gallo R.L., Leung D.Y.M. et al. The skin microbiome is different in pediatric versus adult atopic dermatitis // J Allergy Clin Immunol. 2016. 138:1233–6. 70. Shao Y., Forster S.C., Tsaliki E. et al. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth // Nature. 2019. 574(7776):117–121. 71. Song S., Wang J., Martino C., Jiang L. Thompson W Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding // Med (N Y) 2021 Aug 13. 2(8):951-964.e5 72. Stewart C.J., Ajami N.J., O’Brien J.L., Hutchinson D.S., Smith D.P., Wong M.C., Ross M.C., Lloyd R.E., Doddapaneni H., Metcalf G.A. Temporal development of the gut microbiome in early childhood from the TEDDY study// Nature. 2018. 562:583–588. 73. Stearns J.C., Simioni J., Gunn E. et al. Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants // Sci Rep, 2017. 7(1): p. 16527. 74. Subramanian S., Huq S., Yatsunenko T., Haque R., Mahfuz M., Alam M.A., Benezra A., DeStefano J., Meier M.F., Muegge B.D., et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children // Nature. 2014. 510:417–421. 75. Toscano M., De Grandi R., Peroni D.G., Grossi E., Facchin V., Comberiati P., Drago L. Impact of delivery mode on the colostrum microbiota composition // BMC Microbiol. 2017. 17:205. 76. Tun H.M., Konya T., Takaro T.K. et al. Exposure to household furry pets influences the gut microbiota of infant at 3–4 months following various birth scenarios // Microbiome, 2017. 5(1): p. 40. 77. Zhong H., Penders J., Shi Z., Ren H., Cai K., Fang C., Ding Q., Thijs C., Blaak E.E., Stehouwer C.D.A., et al. Impact of early events and lifestyle on the gut microbiota and metabolic phenotypes in young school-age children // Microbiome. 2019. 7:2. 78. Zwittink R.D., Renes I.B., van Lingen R.A., et al. Association between duration of intravenous antibiotic administration and early-life microbiota development in late-preter infants // Eur J Clin Microbiol Infect Dis, 2018. 37(3): p. 475–483. 79. Milani C, Duranti S, Bottacini F, Casey E, et al. First human gut microbial colonizers: Composition, activity, and health implications of the infant gut microbiota// Microbiol Mol Biol Rev. 2017. 81(4). ph: e00036–17. References: [1] 1. Antonova L.K., Samoukina A.M., Alekseeva Yu.A., Fedotova T.A., Petrova O.A., Strakhova S.S. Sovremennyi vzglyad na formirovanie mikrobioty pishchevaritel'nogo trakta u detei pervogo goda zhizni [A modern view on the formation of the microbiota of the digestive tract in children of the first year of life]. Sovremennye problemy nauki i obrazovaniya [Modern problems of science and education]. 2018. №6. pp. 115-122. [in Russian]
Number of Views: 101

Key words:

Category of articles: Reviews

Bibliography link

Meiirmanova Z.K., Morenko M.A., Shnaider K.V., Toktabayeva B.Zh., Kozhakhmetov S.S., Zakharova I.N., Duysebaeva A.K., Gatauova M.R. The current state of the problem of the formation and dynamics of the infants' microbiota. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 232-242. doi 10.34689/SH.2023.25.1.027

Авторизируйтесь для отправки комментариев