THE CURRENT STATE OF THE PROBLEM OF THE FORMATION AND DYNAMICS OF THE INFANTS' MICROBIOTA. LITERATURE REVIEW
Relevance: The human's microbiome is a complex and dynamic ecosystem. It plays an important role in the metabolism and physiology of the individual. Research shows a critical relationship between the human microbiome and individual's metabolism. The interaction between the microbiome and human's metabolism affects human health and disease. The more researches are needed with the usage of new technologies for better understanding the formation of the microbiota.
The Aim: General characteristics of modern information about the trajectories of the formation of the microbiome of infants.
Search strategy: The search for publicly available scientific publications was carried out using the following databases of scientific publications and specialized search engines: PubMed, Google Scholar, Web of Science, Сyberleninca. A number of original publications and reviews in the field of research over the past 10 years have been analyzed. As a result of the search, we studied 1695 foreign and russian-language publications, of which 78 publications were included in this review.
Inclusion сriteria: Evidence level A, B publications: meta-analyses, systematic reviews, cohort and cross-sectional studies. Exclusion criteria: short reports, newspaper articles and expert opinion in the form of short messages.
Results and conclusions: We have analyzed current data on the infant's gut microbiome and assessed the impact of delivery and feeding patterns on its development. Unlike infants born vaginally, the gut microbiota of infants born by caesarean section showed significantly less similarity to their maternal microbiome. The type of feeding (natural or artificial), as well as the introduction of complementary foods into the diet of infants, has a significant impact on the composition and functions of the microbiota in the early stages. The composition of the microbiota and the ecological network had distinctive features influenced by the social determinants of health. These results form the basis for understanding the interaction between the gut's microbiome and the human's body at an early age.
Zarina K. Meiirmanova1, https://orcid.org/0000-0002-4997-6704
Marina A. Morenko1, https://orcid.org/0000-0001-9553-3560
Kseniya V. Shnaider1, https://orcid.org/0000-0002-4919-1878
Bakytkul Zh. Toktabayeva2, https://orcid.org/0000-0001-5899-1247
Samat S. Kozhakhmetov3, https://orcid.org/0000-0001-9668-0327
Irina N. Zakharova4,
Arailym K. Duysebaeva1, https://orcid.org/0000-0003-4249-7652
Madina R. Gatauova1, https://orcid.org/0000-0002-6517-192X
1NJSC "Astana Medical University", Astana, Republic of Kazakhstan;
2NJSC "Semey Medical University", Semey, Republic of Kazakhstan;
3. "Center for Life Sciences", "Nazarbayev University", Astana, Republic of Kazakhstan;
4. Department of Pediatrics named after academician G.N. Speransky, «National Medical Research Center for Children's Health», Moscow, Russian Federation.
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Meiirmanova Z.K., Morenko M.A., Shnaider K.V., Toktabayeva B.Zh., Kozhakhmetov S.S., Zakharova I.N., Duysebaeva A.K., Gatauova M.R. The current state of the problem of the formation and dynamics of the infants' microbiota. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 232-242. doi 10.34689/SH.2023.25.1.027Related publications:
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