THE MAIN POINTS OF TREATMENT OF PATIENTS WITH MECHANICAL JAUNDICE
Introduction. Structural changes in the liver and cholemia due to MJ lead to the development of endotoxicosis, which in turn leads to a violation of the antitoxic function of the liver, prolonged MJ reduces the function of the nephron. All this leads to the development of renal-hepatic insufficiency. Thrombohemorrhagic changes develop in the vascular bed, leading to the development of DIC syndrome. Despite the achievements of intensive therapy and surgery of the biliary tract, with mechanical jaundice, mortality also occurs.
The purpose of the study. Analysis of modern concepts concerning hemostatic disorders in mechanical jaundice and practical recommendations on therapeutic strategies.
Search strategy: to achieve this goal, an analysis of scientific publications in evidence-based medicine databases (PubMed) was carried out using specialized search engines (Google Scholar) from 2005 to 2020. All studies and reviews devoted to this topic were analyzed by the authors and classified according to their methodology - retrospectively, prospectively, descriptively or comparatively. Inclusion criteria: research of high methodological quality: meta-analysis, systematic review and cohort studies, as well as publications with clearly formulated and statistically proven conclusions in English and Russian. Exclusion criteria: summary of reports, reports in the form of abstracts, advertising articles.
Results. Coagulopathy, sepsis and renal insufficiency remain the main problems in patients with mechanical jaundice. The main preventive strategies include the elimination of coagulopathy by parenteral administration of vitamin K and the replacement of clotting factors, an adequate volume load to ensure euvolemia and the appropriate use of antibiotics. Patients with established complications of cholangitis and renal insufficiency require urgent decompression of the biliary tract. In patients with mechanical jaundice, risk stratification is important for making informed therapeutic decisions. Patients with unacceptable concomitant diseases may be suitable only for non-surgical palliative therapy. For those patients who are candidates for biliary tract resection, the issue of preoperative drainage is controversial.
Conclusion. Currently, patients with mechanical jaundice can be operated with a lower mortality rate, and the percentage of complications can be minimized with relatively simple clinical interventions. The presented review, based on literary sources, is a recommendation for the management of patients with mechanical jaundice in order to prevent complications.
Meyrbek J. Aimagambetov1, https://orcid.org/0000-0003-4699-8200
Meruert T. Orazgalieva1, https://orcid.org/0000-0002-9899-9881
Nazarbek B. Omarov1, http://orcid.org/0000-0002-6201-8263
Marat K. Syzdykbayev1, https://orcid.org/0000-0002-0561-4111
Samatbek T. Abdrakhmanov1, https://orcid.org/0000-0002-4270-3498
Medet A. Auenov1, https://orcid.org/0000-0002-1809-9091
Ainash S. Orazalina1, https://orcid.org/0000-0003-4594-0138
Aldiyar Ye. Masalov1, https://orcid.org/0000-0002-2844-037X
Zhansaya M. Muratkhanova1, https://orcid.org/0000-0002-6639-8950
Moldir M. Akbayeva1, https://orcid.org/0000-0002-3616-7000
1 NCJSC "Semey Medical University" Semey, Republic of Kazakhstan.
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Aimagambetov M.J., Orazgalieva M.T., Omarov N.B., Syzdykbayev M.K., Abdrakhmanov S.T., Auenov M.A., Orazalina A.S., Masalov A.Ye., Muratkhanova Zh.M., Akbayeva M.M. The main points of treatment of patients with mechanical jaundice // // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 2, pp. 206-215. doi 10.34689/SH.2023.25.2.027Related publications:
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