MODERN UNDERSTANDING OF THE DEVELOPMENT AND METHODS OF DIAGNOSIS IN HIRSCHSPRUNG'S DISEASE. LITERATURE REVIEW
Introduction: Hirschsprung's disease - is a complex congenital pathology that requires reconstructive surgical interventions. This is a multigenetic disease, refers to neurocrystopathies, an etiopathogenetic factor in the development of Hirschsprung's disease is a violation of the development of the enteral nervous system of the intestine in the form of agangliosis. Analyzes the literature reflecting modern views on Hirschsprung's disease in children, as well as modern diagnostic methods using immunohistochemical research and treatment of the disease. The introduction of new methods of examination and surgical treatment is still difficult and ambiguous.
Objective: To review the current literature on the pathogenesis of Hirschsprung's disease, clinical features of the course of the disease in the neonatal period and modern diagnostic methods.
Search strategy: The search and analysis of material for writing articles were carried out in the information bases and websites PubMed, Scopus, Web of Science, Journal Neonatology, Journal Pediatrics, Journal of Maternal-fetal and neonatal medicine, BMC (biomedcentral.com). The depth of the search included data for the last 15-20 years. From more than 110 literary sources, 74 were selected as analytical material for this article.
Results: Hirschsprung's disease is a complex congenital pathology of the intestinal tube, refers to neurocrystopathies. They have complex genetic aspects, can be combined with other congenital and chromosomal pathologies.
Conclusions: Identification of ganglion cells in newborns and premature infants can be a difficult task since neurons are often undifferentiated and imperfect. Therefore, determining ganglion cells based solely on their appearance is not always an easy task. The use of immunohistochemistry with calretinin is a highly sensitive and specific diagnostic tool for histopathological examination in case of suspected Hirschsprung's disease.
Gulmira T. Kaukenbayeva 1,2, https://orcid.org/0000-0002-6689-7135
Nurlan N. Akhparov2,
Riza Z. Boranbayeva 1, https://orcid.org/0000-0002-7154-6436
Rasulbek R. Aipov1,
Gauhar T. Tassibekova1, https://orcid.org/0000-0002-1301-6496
Moldir M. Kalabaeva2,
Gulmira B. Altynbaeva2
1 NJSC “Asfendiyarov Kazakh National Medical University”, Almaty, Republic of Kazakhstan;
2 JSC "Scientific Center of Pediatrics and Pediatric Surgery " Almaty, Republic of Kazakhstan.
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Kaukenbayeva G.T., Akhparov N.N., Boranbayeva R.Z., Aipov R.R., Tasibekova G.T., Kalabaeva M.M., Altynbaeva G.B. Modern understanding of the development and methods of diagnosis in Hirschsprung's disease. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 2, pp. 216-224. doi 10.34689/SH.2023.25.2.028Related publications:
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