THE USE OF PHOTODYNAMIC THERAPY IN WOMEN WITH HPV-ASSOCIATED PRECANCEROUS CERVICAL DISEASE. LITERATURE REVIEW
Relevance: This article provides a brief overview of modern methods of diagnosis and treatment of cervical cancer. Special attention is paid to the etiological factor of cervical precancerous development – human papillomavirus (HPV). The role of the immune system during HPV infection and the main methods of treatment of cervical dysplasia are described. The article also discusses in detail the mechanism of action of photodynamic therapy (PDT) in the treatment of cervical dysplasia in women of childbearing age.
PDT is a high-tech treatment method that uses a combination of photosensitizer, light and molecular oxygen. The method is based on the mechanisms of free radical oxidation, violation of the vascular stroma of tumors and elimination under the action of immune cells. It is a non-invasive, effective and safe treatment that allows you to damage and destroy the structures of the affected area. However, in order to normalize the immune response, providing a stable regression of carcinogenesis, prolonged elimination of HPV is necessary. The article presents an overview of foreign and domestic articles on the safety and effectiveness of the use of PDT. The role of the immune response in HPV-associated precancerous diseases of the cervix is considered. Destructive and non-destructive methods of treatment of cervical dysplasia are described. The first sources of photodynamic therapy in gynecology, as well as the advantages and disadvantages of PDT are disclosed in this article.
Aim: to analyze the literature data on the use of photodynamic therapy in women with HPV-associated precancerous cervical disease.
Search strategy: Analysis of publications on the research topic, sources indexed in the databases of the electronic library e-Library, Google Academy, Pubmed, Web of Science, Scopus. The inclusion criteria were: reports on randomized and cohort studies conducted on large populations, meta-analyses and systematic reviews, original full-text articles in English and Russian that are publicly available and contain statistically confirmed conclusions. Exclusion criteria: summary reports, newspaper articles and personal messages. The search depth was 10 years (2013-2023). The relevant search yielded 2,200 articles, after the initial analysis, 45 articles were selected for the final analysis
Results: According to the results of our literature review, the results of studies show that the use of photodynamic therapy in women with HPV-associated precancerous cervical disease is a promising research area. Further clinical studies are needed to evaluate the effectiveness, safety and optimal timing.
Nasrulla A. Shanazarov1, https://orcid.org/0000-0002-2976-259X
Saule D. Kisikova1, https://orcid.org/0000-0003-4584-9342
Rustam K. Albayev1, https://orcid.org/0000-0002-2689-2663
Maksim S. Afanasyev2, https://orcid.org/0000-0002-5860-4152
Zaituna G. Khamidullina3, https://orcid.org/0000-0002-5324-8486
Tatiana G. Grishacheva4, https://orcid.org/0000-0002-9515-914X
Akmaral Yе. Khangeldi3, https://orcid.org/0000-0003-0603-1230
1 Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, Republic of Kazakhstan;
2 Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation;
3 NJSC "Astana Medical University", Astana, Republic of Kazakhstan;
4 The First St. Petersburg State Medical University named after Academician I.P. Pavlova, Russia, St. Petersburg, Russian Federation.
1. Бенберин В.В., Шаназаров Н.А., Сарсебеков Е.К., Сейтбекова К.С., Алдаберген Г.С. Флуоресцентная диагностика, фотодинамическая терапия и внутривенное лазерное облучение крови при предраковых заболеваниях шейки матки, ассоцированных вирусом папилломы человека (обзор литературы) // Вестник медицинского Центра Управления делами Президента республики Казахстан, 2020. №2 (79), С.138-142
2. Залетаев Д.В., Немцова М.В., Бочков Н.П. Метилирование ДНК как этиологический фактор канцерогенеза // Вестник Российской академии медицинских наук. 2002. № 4. C. 6–11.
3. Караулов А.В., Афанасьев М.С., Петрищев Н.Н. др. Фотодинамическая терапия: иммуномодулирующий метод в онкогинекологии. 1-е изд., Москва: ООО «Контакт», 2020. 144 c.
4. Киселев В.И. и др. Этиологическая роль вируса папилломы человека в развитии рака шейки матки: генетические и патогенетические механизмы, возможности терапии и профилактики // Гинекология. 2004. № 4 (6). C. 174–180.
5. Киселев В.И., Аполихина И.А., Муйжнек Е.Л. Патогенетические подходы к лечению ВПЧ-ассоциированных заболеваний шейки матки под ред. Прилепской В.Н., М.: МЕДпресс-информ, 2008.C. 87–94.
6. Лопухов П.Д. Научно-методическое обоснование направлений оптимизации эпидемиологического надзора и профилактики папилломавирусной инфекции 2018. 56c.
7. Нургазиев К.Ш., Жылкайдарова А.Ж., Кайрбаев М.Р, Болатбекова Р.О. Оценка показателей заболеваемости и смертности от рака шейки матки в Республике Казахстан за 2004 – 2014 годы // Онкология и радиология Казахстана, 2016, Т.39, №1, С.3-9.
8. Роговская С.И. [и др.]. Распространенность папилломавирусной инфекции в России // Эпидемиоло-гия и Вакцинопрофилактика. 2012. № 62 (1). C. 25–33.
9. Ротару Т.В., Ротару Л.И., Лапочкина Н.П. Генетическая предрасположенность при раке шейки матки // Акушерство, Гинекология и Репродукция. 2020. 14(2):218–228. https://doi.org/10.17749/2313-7347.139
10. Сейтбекова К.С., Шаназаров Н.А., Сарсебеков Е.К., Алдаберген Г.С., Ташпулатов Т.Б. Фотодинамическая терапия ВПЧ-ассоцированной цервикальной интераэпителиальной неоплазии // Материалы III международного Форума онкологии и радиологии, Москва, 21-25 сентября 2020г. С. 59-60.
11. Странадко Е.Ф., Рябов М.В. Новая лазерная технология в медицине - Фотодинамическая терапия. // Анналы хирургии. 2003. №2. С.16-20.
12. Шаназаров Н.А. Флуоресцентная диагностика и фотодинамическая терапия в лечении злокачественных новообразований // Ахмет Ясауи университетінің хабаршысы, 2016. №4(102), С. 549-555.
13. Шаназаров Н.А. Флуоресцентная диагностика и фотодинамическая терапия злокачественных новообразований (обзор литературы) // Вестник Медицинского центра Управления Делами президента Республики Казахстан. 2014. №2 (55). С. 62-67.
14. Шаназаров Н.А. Фотодинамическая терапия и флуоресцентная диагностика в онкологии (обзор литературы) // Сборник научных трудов «Современные вопросы клинической медицины». Национальный научный центр онкологии и трансплантологии. 2015. С. 153-158.
15. Шаназаров Н.А., Ахетов А.А., Сейдалин Н.К. Первый опыт применения фотодинамической терапии в Казахстане // Материалы VI Всероссийской конференции с международным участием «Фотодинамическая терапия и Фотодиагностика» Ростов на Дону 14-16 сентября 2017. Biomedical photonics. Специальный выпуск, 2017. С.37-38.
16. Abreu Velez A.M., Howard M.S. Tumor-suppressor genes, cell cycle regulatory checkpoints, and the skin // N Am J Med Sci. 2015. 7(5):176–88. DOI: 10.4103/1947-2714.157476.
17. Afanasiev M. et al. The Multi-Course Approach of Photodynamic Therapy to Treat Invasive Cervical Cancer IB2: A Case Report // Case Reports in Oncology. 2021. № 1 (14). C. 506–519.
18. Afanasiev M.S. et al. Photodynamic therapy for early-stage cervical cancer treatment // Photodiagnosis and Photodynamic Therapy. 2022. №37. C. 102-620.
19. Ara Unanyan, Pivazyan L., Davydova Ju., Murvatova K., Khrapkova A., Movsisyan R., Ishchenko A., Ishchenko A. A chlorin e6 derivative-mediated photodynamic therapy for patients with cervical and vaginal low-grade squamous intraepithelial lesions: a retrospective analysis// Translational Biophotonics. 2022. с
20. Balasubramaniam S.D., Balakrishnan V., Oon C.E., Kaur G. Key Molecular Events in Cervical Cancer Development // Medicina (Kaunas). 2019 Jul 17;55(7):384. doi: 10.3390/medicina55070384. PMID: 31319555; PMCID: PMC6681523.
21. Bruni L., Barrionuevo-Rosas L., Albero G., Aldea M., Serrano B., Valencia S., Brotons M., Mena M., Cosano R., Munoz J., Bosch F.X., de Sanjose S., Castellsague X. (ICO Information Centre on HPV and Cancer (HPV Information Centre)) / Human Papillomavirus and Related Diseases in Kazakhstan // Summary Report. 2015. С.12-23.
22. Cohen P.A. et al. Cervical cancer // Lancet, 2019, vol. 393, no. 10167, pp. 169–182. doi: org/10.1016/S0140–6736 (18)32470-X
23. Сohen P.A. Questioning the value of margin status in treated cervical precancer // Lancet Oncol. 2017. 18:1565–6. 10.1016/S1470-2045(17)30839-2.
24. Della Fera A.N., Warburton A., Coursey T.L., Khurana S., McBride A.A. Persistent Human Papillomavirus Infection // Viruses. 2021 Feb 20. 13(2):321. doi: 10.3390/v13020321. PMID: 33672465; PMCID: PMC7923415.
25. Domenico Di M., Giovane G., Kouidhi S. et al. HPV epigenetic mechanisms related to oropharyngeal and cervix cancers // Cancer Biol Ther. 2018. 19(10):850–7. DOI: 10.1080/15384047.2017.1310349.
26. Espinoza H., Ha K.T., Pham T.T., Espinoza J.L. Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers // Microorganisms. 2021 Oct 3. 9(10):2092. doi: 10.3390/microorganisms9102092. PMID: 34683414; PMCID: PMC8539927.
27. Gheit T. Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology // Front Oncol. 2019 May 8;9:355. doi: 10.3389/fonc.2019.00355. PMID: 31134154; PMCID: PMC6517478.
28. Gu L., Cheng M., Hong Z., Di W., Qiu L. The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study // Photodiagnosis Photodyn Ther. 2021 Mar;33:102172. doi: 10.1016/j.pdpdt.2020.102172. Epub 2021 Jan 2. PMID: 33401023.
29. Kristin A Keefe, Yona Tadir, Bruce Tromberg, Michael Berns, Kathryn Osann, Rasha Hashad, Bradley J Monk Photodynamic therapy of high-grade cervical intraepithelial neoplasia with 5-aminolevulinic acid // Lasers Surg. Med. 2002. 31:289–293.
30. Kuguyo O., Tsikai N., Thomford N.E. et al. Genetic susceptibility for cervical cancer in African populations: what are the host genetic drivers? OMICS. 2018. 22(7):468–83. DOI: 10.1089/omi.2018.0075.
31. Li D., Zhang F., Shi L. et al. Treatment of HPV infection-associated low grade cervical intraepithelial neoplasia with 5-aminolevulinic acid-mediated photodynamic therapy Photodiagn // Photodyn. Ther., 2020, 32 Article. 101974
32. Nam M., Seo S.S., Jung S., Jang S.Y., Lee J., Kwon M. et al. Comparable plasma lipid changes in patients with high-grade cervical intraepithelial neoplasia and patients with cervical cancer // J Proteome Res. 2021. 20:740–50. 10.1021/acs.jproteome.0c00640
33. Pak R., Sadykova T., Kaidarova D., Gultekin M., Kasimova G., Tanabayeva S., Ussebayeva N., Tazhiyeva A., Senbekov M., Fakhradiyev I. The Life Quality and Sexual Function of Women Underwent Radical Hysterectomy // Asian Pac J Cancer Prev. 2021 Feb 1. 22(2):581-589. doi: 10.31557/APJCP.2021.22.2.581. PMID: 33639677; PMCID: PMC8190359.
34. Peter Hillemanns, Francisco Garcia, Karl Ulrich Petry, Vladimír Dvorak, Oliver Sadovsky, Ole-Erik Iversen, Mark H Einstein A randomized study of hexaminolevulinate photodynamic therapy in patients with cervical intraepithelial neoplasia // American journal of obstetrics and gynecology, 2015 Apr. 212(4).
35. Peter Hillemanns, Karl-Ulrich Petry, Philipp Soergel, Pierre Collinet, Katty Ardaens, Julia Gallwas, Alexander Luyten, Christian Dannecker Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia // Lasers Surg. Med. 46:456–461, 2014.
36. Philipp Soergel, Gunn Fallås Dahl, Mathias Onsrud, Peter Hillemanns Photodynamic therapy of cervical intraepithelial neoplasia 1–3 and human papilloma virus (HPV) infection with methylaminolevulinate and hexaminolevulinate // Lasers Surg. Med. 2012. 44: 468–474.
37. Song D., Li H., Li H., Dai J. Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer // Oncol Lett. 2015, 10(2):600–6. DOI: 10.3892/ol.2015.3295.
38. Sung H. et al. Global cancer statistics 2020: // GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries // CA Cancer J Clin, 2021, vol. 71, no. 3, pp. 209–249. doi: 10.3322/caac.21660.
39. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. 2021 Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries // CA: a cancer journal for clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
40. Tang Y., Su Y., Xu Y., Zhang Y., Shen Y., Qin L., Zhang L., Cao L., Zhou Y., Zhang T., Zhang M. Therapeutic effects of topical photodynamic therapy with 5-aminolevulinic acid on cervical high-grade squamous intraepithelial lesions // Photodiagnosis Photodyn Ther. 2022 Apr 29.39:102884. doi: 10.1016/j.pdpdt.2022.102884. Epub ahead of print. PMID: 35500740.
41. Tao X.H., Guan Y., Shao D., Xue W., Ye F.S., Wang M., He M.H. Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia: a systemic review // Photodiagnosis Photodyn Ther. 2014 Jun. 11(2):104-12
42. Wenjia Zhang, Aijia Zhang, Wende Sun, Ying Yue, Hong Li Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia and human papilloma virus infection: A systematic review and meta-analysis of randomized clinical trials // Medicine (Baltimore). 2018 May. 97(21).
43. Zhou C., Tuong Z.K., Frazer I.H. Papillomavirus immune evasion strategies target the infected cell and the local immune system // Front Oncol. 2019. 9:682. DOI: 10.3389/fonc.2019.00682.
References:
1. Benberin V.V., Shanazarov N.A., Sarsebekov E.K., Seitbekova K.S., Aldabergen G.S. Fluorestsentnaya diagnostika, fotodinamicheskaya terapiya i vnutrivennoe lazernoe obluchenie krovi pri predrakovykh zabolevaniyakh sheiki matki, assotsirovannykh virusom papillomy cheloveka (obzor literatury) [Fluorescent diagnostics, photodynamic therapy and intravenous laser irradiation of blood for precancerous diseases of the cervix associated with the human papillomavirus (literature review)]. Vestnik meditsinskogo Tsentra Upravleniya delami Prezidenta respubliki Kazakhstan [Bulletin of the Medical Center for the Administration of the President of the Republic of Kazakhstan], 2020. №2 (79), pp.138-142. [in Russian]
2. Zaletaev D.V., Nemtsova M.V., Bochkov N.P. Metilirovanie DNK kak etiologicheskii faktor kantserogeneza [DNA methylation as an etiological factor of carcinogenesis]. Vestnik Rossiiskoi akademii meditsinskikh nauk [Bulletin of the Russian Academy of Medical Sciences.]. 2002. № 4. pp. 6–11. [in Russian]
3. Karaulov A.V., Afanas'ev M.S., Petrishchev N.N., Grishacheva T.G., Nesvizhskii Yu.V. i dr. Fotodinamicheskaya terapiya: immunomoduliruyushchii metod v onkoginekologii [Photodynamic therapy: an immunomodulatory method in oncogynecology.] 1-e izd., Moskva: OOO «Kontakt», 2020. 144 p. [in Russian]
4. Kiselev V.I. i dr. Etiologicheskaya rol' virusa papillomy cheloveka v razvitii raka sheiki matki: geneticheskie i patogeneticheskie mekhanizmy, vozmozhnosti terapii i profilaktiki [Etiological role of human papillomavirus in the development of cervical cancer: genetic and pathogenetic mechanisms, possibilities of therapy and prevention]. Ginekologiya [Gynecology]. 2004. № 4(6). pp.174–180. [in Russian]
5. Kiselev V.I., Apolikhina I.A., Muizhnek E.L. Patogeneticheskie podkhody k lecheniyu VPCh-assotsiirovannykh zabolevanii sheiki matki. [Pathogenetic approaches to the treatment of HPV-associated cervical diseases]. pod red. Prilepskoi V.N., Moskva: MEDpress-inform, 2008. pp. 87–94. [in Russian]
6. Lopukhov P.D. Nauchno-metodicheskoe obosnovanie napravlenii optimizatsii epidemiologicheskogo nadzora i profilaktiki papillomavirusnoi infektsii 2018. [Scientific and methodological substantiation of the directions of optimization of epidemiological surveillance and prevention of papillomavirus infection]. Moskva, 2004.[in Russian]
7. Nurgaziev K.Sh., Zhylkaidarova A.Zh., Kairbaev M.R, Bolatbekova R.O. Otsenka pokazatelei zabolevaemosti i smertnosti ot raka sheiki matki v Respublike Kazakhstan za 2004 – 2014 gody [Assessment of morbidity and mortality from cervical cancer in the Republic of Kazakhstan for 2004-2014.]. Onkologiya i radiologiya Kazakhstana [Oncology and radiology of Kazakhstan.] 2016, T.39, №1, pp.3-9. [in Russian]
8. Rogovskaya S.I. [i dr.]. Rasprostranennost' papillomavirusnoi infektsii v Rossii [There is no prevalence of papilloma virus and infection in Russia]. Epidemiologiya i Vaktsinoprofilaktika [Epidemiology and Vaccine Prevention]. 2012. № 62 (1). рр. 25–33. [in Russian]
9. Rotaru T.V., Rotaru L.I., Lapochkina N.P. Geneticheskaya predraspolozhennost' pri rake sheiki matki [Genetic predisposition' in cervical cancer]. Akusherstvo, Ginekologiya i Reproduktsiya [Obstetrics, Gynecology and Reproduction]. 2020. 14(2):218–228. https://doi.org/10.17749/2313-7347.139 [in Russian]
10. Seitbekova K.S., Shanazarov N.A., Sarsebekov E.K., Aldabergen G.S., Tashpulatov T.B. Fotodinamicheskaya terapiya VPCh-assotsirovannoi tservikal'noi interaepitelial'noi neoplazii [Photodynamic therapy of HPV-associated cervical intraepithelial neoplasia]. Materialy III mezhdunarodnogo Foruma onkologii i radiologii, Moskva, 21-25 sentyabrya [Proceedings of the III International Forum of Oncology and Radiology, Moscow, September 21-25]. 2020g. pp. 59-60. [in Russian]
11. Sidorenko Yu.S., Prikhod'ko E.V. Sovremennye standarty v lechenii raka sheiki matki [Modern standards in the treatment of cervical cancer]. 2005.- 26p. [in Russian]
12. Stranadko E.F., Ryabov M.V. Novaya lazernaya tekhnologiya v meditsine - Fotodinamicheskaya terapiya [New laser technologies in medicine - Photodynamic therapy]. Annaly khirurgii [Annals of Surgery]. 2003. №2. pp.16-20. [in Russian]
13. Shanazarov N.A. Fluorestsentnaya diagnostika i fotodinamicheskaya terapiya v lechenii zlokachestvennykh novoobrazovanii [Fluorescent diagnostics and photodynamic therapy in the treatment of malignant neoplasms.] Akhmet Yasaui universitetіnің khabarshysy [Akhmet Yassawi university bulletin], 2016. №4(102), pp. 549-555. [in Russian]
14. Shanazarov N.A. Fluorestsentnaya diagnostika i fotodinamicheskaya terapiya zlokachestvennykh novoobrazovanii (obzor literatury) [Fluorescent diagnostics and photodynamic therapy of malignant tumors (literature review)]. Vestnik Meditsinskogo tsentra Upravleniya Delami prezidenta Respubliki Kazakhstan [Bulletin of the Medical Center for the Administration of the President of the Republic of Kazakhstan]. 2014. №2 (55). pp. 62-67. [in Russian]
15. Shanazarov N.A. Fotodinamicheskaya terapiya i fluorestsentnaya diagnostika v onkologii (obzor literatury) [Photodynamic therapy and fluorescent diagnostics in oncology (literature review)]. Sbornik nauchnykh trudov «Sovremennye voprosy klinicheskoi meditsiny». Natsional'nyi nauchnyi tsentr onkologii i transplantologii [National Research Center for oncology and transplantology]. 2015. pp. 153-158. [in Russian]
16. Shanazarov N.A., Akhetov A.A., Seidalin N.K. Pervyi opyt primeneniya fotodinamicheskoi terapii v Kazakhstane [The first experience of using photodynamic therapy in Kazakhstan.]. Materialy VI Vserossiiskoi konferentsii s mezhdunarodnym uchastiem «Fotodinamicheskaya terapiya i Fotodiagnostika» Rostov na Donu 14-16 sentyabrya 2017. Biomedical photonics. Spetsial'nyi vypusk [Proceedings of the VI All-Russian conference with the international participation of Rostov-on-Don "photodynamic therapy and photodiagnostics" on September 14-16, 2017. Biomedical photonics. Special edition]., 2017. pp.37-38. [in Russian].
Number of Views: 161
Category of articles:
Reviews
Bibliography link
Shanazarov N.A., Kisikova S.D., Albayev R.K., Afanasyev M.S., Khamidullina Z.G., Grishacheva T.G., Khangeldi A.Yе. The use of photodynamic therapy in women with HPV-associated precancerous cervical disease. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 4, pp. 231-240. DOI 10.34689/SH.2023.25.4.028Related publications:
INTERRELATION OF INTRAABDOMINAL HYPERTENSION AND MARKERS OF GASTROINTESTINAL TRACT INJURY IN PATIENTS WITH MULTIORGAN DYSFUNCTION
DRUG-INDUCED LIVER INJURY AND GENDER DIFFERENCES
QUALITY OF LIFE IN PRIMARY BILIARY CHOLANGITIS AND ITS ASSESSMENT
DIAGNOSTIC AND THERAPEUTIC LAPAROSCOPY FOR ABDOMINAL INJURIES. REVIEW
METHODS FOR SCHOOL-AGE CHILDREN NUTRITIONAL STATUS ASSESSMENT: FOCUS ON ANTHROPOMETRIC PARAMETERS. A REVIEW.