THE CLINICAL PICTURE OF COVID-19 IN ADULT PATIENTS OF THE TURKESTAN REGION, DEPENDING ON COMORBID DISEASES
Currently, the new coronavirus infection and its consequences, despite significant progress in vaccination and treatment, does not lose relevance.
The purpose of the study: To conduct a comparative analysis of symptoms depending on the presence of comorbid diseases in patients with COVID-19 hospitalized in infectious hospitals of the Turkestan region.
Research methods: A retrospective observational study was conducted, during which we analyzed the data of patients with COVID-19 hospitalized in infectious diseases hospitals of the Turkestan region in 2020-2021. The data of 958 patients with COVID-19 were randomly selected from the information system, information about the clinical symptoms of COVID-19 and comorbidities were extracted from medical records. The collected data were entered into the trial version of the SPSS program (SPSS 20 Inc, Chicago, IL, USA), p < 0,05 was considered as significance threshold.
Results: In the studied sample of patients with COVID-19, the most common comorbidities were diseases of the respiratory system - 45.6%, in second place were cardiovascular diseases - 36.2%. The most frequent symptoms upon admission were cough - 68.8%, fever - 56.7%, and shortness of breath - 47.4%. Less frequent symptoms were diarrhea -3%, dizziness - 29%, vomiting - 12.5%, myalgia - 19.1%. The data obtained by us indicate that in COVID-19 patients with comorbid diseases of the cardiovascular system, respiratory organs, nervous system and diabetes mellitus, such clinical symptoms as cough over 80.0%, diarrhea over 7.0%, dizziness above 41.0%, myalgia – above 27.0%, shortness of breath above 64.0 % and fever over 71.0 % were statistically significantly more common.
Conclusions: In the older age group, clinical symptoms were significantly more common. In general, in the presence of comorbid pathology, almost all the symptoms were observed much more often, which indicates a more severe clinical course COVID-19 in this category of patients.
Karlygash Zh. Sadykova1, https://orcid.org/0000-0002-9120-8565
Gulnaz O. Nuskabayeva1, https://orcid.org/0000-0002-2906-1427
Kamshat M. Madenbay2, https://orcid.org/0000-0002-1069-7125
Khadicha B. Kulakhmetova1, Dilbar N. Aidarbekova1,
Dinara Sh. Azizhodzhayeva1,
Kanatzhan S. Kemelbekov3, https://orcid.org/0000-0001-9482-9079
Аiman А. Mussina4, https://orcid.org/0000-0002-0864-1238
1 Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Republic of Kazakhstan;
2 Al-Farabi Kazakh National University, Almaty, Republic of Kazakhstan;
3 South Kazakhstan Medical Academy, Shymkent, Republic of Kazakhstan;
4 NJSC «Astana Medical University», Astana c., Republic of Kazakhstan.
1. CDC COVID-19 Response Team. Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019 − United States, February 12 − March 28, 2020 // MMWR Morb Mortal Wkly Rep. 2020. N69(13). P. 382-386. doi: 10.15585/mmwr.mm6913e2.
2. Chaolin Huang, Yeming Wang, Xingwang Li et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China // Lancet. 2020. N 395. P. 497-506. doi: 10.1016/S0140-6736(20)30183-5.
3. Cheng Y., Luo R., Wang K. et al. Kidney disease is associated with in-hospital death of patients with COVID-19 // Kidney International. 2020. N 97(5). P. 829-838. doi: 10.1016/j.kint.2020.03.005.
4. Diao B., Wang C., Wang R., et al. Human kidney is a target for novel severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection // Nat Commun. 2021. N 12(1). P. 2506. doi: 10.1038/s41467-021-22781-1.
5. Gentile S., Strollo F., Ceriello A. COVID-19 infection in Italian people with diabetes: lessons learned for our future (an experience to be used) // Diabetes Res Clin Pract. 2020. N162. 108137. doi: 10.1016/j.diabres.2020.108137. Epub 2020 Apr 4.
6. Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Andrew Parviz Zarei, Farzaneh Hekmatnia, Shamim Shafieyoon. Comparison of pulmonary computed tomography scan findings and clinical symptoms of COVID-19 in three outbreak peaks in Isfahan, Iran // Res Med Sci. 2022. N 27. P. 81. doi: 10.4103/jrms.jrms_501_21. eCollection 2022.
7. Grasselli G., Zangrillo A., Zanella A., et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region. Italy // JAMA. 2020. N 323. P. 1574–158.
8. Han R., Huang L., Jiang H., Dong J., Peng H., Zhang D. Early clinical and CT manifestations of coronavirus disease 2019 (COVID 19) pneumonia // AJR Am J Roentgenol. 2020. N 215. P. 338 343.
9. Jatin Machhi, Jonathan Herskovitz, Ahmed M. Senan et al. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections // Journal of Neuroimmune Pharmacology. 2020. N 15(3). P. 359-386. doi: 10.1007/s11481-020-09944-5.
10. Klok F.A., Kruip M., van der Meer N.J.M., Arbous M.S., Gommers D., Kant K.M., Kaptein F.H.J., van Paassen J., Stals M.A.M., Huisman M.V., Endeman H. Incidence of thrombotic complications in critically ill ICU patients with COVID-19 // Thromb Res. 2020. N 191. P. 145–147.
11. Kollias A., Kyriakoulis K.G., Dimakakos E., Poulakou G., Stergiou G.S., Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action // Br J Haematol. 2020. N 189. P. 846–847.
12. Lu H. Drug treatment options for the 2019-new coronavirus (2019-nCoV) // Biosci Trends. 2020. N 14. P. 69-71.
13. Mao L., Jin H., Wang M., Hu Y., Chen S., He Q., Chang J., Hong C., Zhou Y., Wang D., Miao X., Li Y., Hu B. Neurologic manifestations of hospitalized patients with Coronavirus disease 2019 in Wuhan, China // JAMA Neurol. 2020. N 77. P. 1–9.
14. Mao R., Qiu Y., He J.S., Tan J.Y., Li X.H., Liang J., Shen J., Zhu L.R., Chen Y., Iacucci M., Ng S.C., Ghosh S., Chen M.H. Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis // Lancet Gastroenterol Hepatol. N 5. P. 667–678.
15. Mahmoud Gheblawi, Kaiming Wang, Anissa Viveiros et al. Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2 // Circ Res. 2020. N 126(10). P.1456-1474. doi: 10.1161/CIRCRESAHA.120.317015.
16. Manish Bansal Cardiovascular disease and COVID-19 // Diabetes Metab Syndr. 2020. N 14(3). P. 247-250. doi: 10.1016/j.dsx.2020.03.013.
17. Onder G., Rezza G., Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy // JAMA. 2020. https://doi.org/10.1001/jama.2020.4683.
18. Rodriguez Morales A.J., Cardona Ospina J.A., Gutiérrez Ocampo E., Villamizar Peña R., Holguin Rivera Y., Escalera Antezana J.P. et al. Clinical, laboratory and imaging features of COVID 19: Asystematic review and meta-analysis // Travel Med Infect Dis. 2020.N 34. 101623. doi: 10.1016/j.tmaid.2020.101623. Epub 2020 Mar 13.
19. Rogers J.P., Chesney E., Oliver D., Pollak T.A., McGuire P., Fusar-Poli P., Zandi M.S., Lewis G., David A.S. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic // Lancet Psychiatry. 2020. N 7. P. 611–627.
20. Struyf T., Deeks J.J., Dinnes J., Takwoingi Y., Davenport C., Leeflang M.M. et al. Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID 19 disease // Cochrane Database Syst Rev. 2020. N 7(7). CD013665. doi: 10.1002/14651858.CD013665.
21. Sultan S., Altayar O., Siddique S.M., Davitkov P., Feuerstein J.D., Lim J.K., Falck-Ytter Y., El-Serag H.B. AGA Institute rapid review of the GI and liver manifestations of COVID-19, meta-analysis of international data, and recommendations for the Consultative Management of Patients with COVID-19 // Gastroenterology. 2020. N 159(1). P. 320-334.e27. doi: 10.1053/j.gastro.2020.05.001.
22. Swaraj Waddankeri, Kshitij Arora, Nitin Mallasure, Bharat Konin, Basavaraj G Mangshetty. Clinical, Biochemical, and Radiological Presentation of RT-PCR-Positive vs RT-PCR-Negative SARS-CoV-2 Pneumonia Requiring ICU Care: An Observational, Cross-Sectional, Single-Center Study in Kalaburagi, Kalyana Karnataka // Cureus. 2022.N 14(11). e31493. doi:10.7759/cureus.31493.
23. Tavazzi G., Pellegrini C., Maurelli M., Belliato M., Sciutti F., Bottazzi A., Sepe P.A., Resasco T., Camporotondo R., Bruno R., Baldanti F., Paolucci S., Pelenghi S., Iotti G.A., Mojoli F., Arbustini E. Myocardial localization of coronavirus in COVID-19 cardiogenic shock // Eur J Heart Fail. 2020. N 22. P. 911–915.
24. Wang B.Hu, Hu C. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China // JAMA. 2020. N 323(11). P. 1061–1069.
25. Wang B., Li R., Lu Z., Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis // Aging (Albany NY). 2020. N 12(7). P.6049−6057. https://doi.org/10.18632/aging.103000.
26. Yang X., Yu Y., Xu J., et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study // Lancet Respir Med. 2020. N 8. P. 475–481.
27. Yang J., Zheng Y., Gou X., Pu K., Chen Z., Guo Q. et al. Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis // Int J Infect Dis. 2020. N 94. P. 91–95. http://dx.doi.org/10.1016/j.ijid. 2020.03.017.
28. Zhonghua Liu, Xing Bing, Xue Za Zhi. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China // Epidemiology Working Group for Ncip Epidemic Response. 2020. N 41(2). P. 145−151. https://doi.org/10.3760/cma.j.issn.0254-6450.2020.02.003.
29. Zhou B., She J., Wang Y., Ma X. A case of coronavirus disease 2019 with concomitant acute cerebral infarction and deep vein thrombosis // Front Neurol. N 11. P. 296 doi: 10.3389/fneur.2020.00296. eCollection 2020.
30. Zhou F., Yu T., Du R. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study // Lancet. 2020. N 395. P. 1054–1062.
Number of Views: 87
Category of articles:
COVID-19 - Topical Subject
Bibliography link
Sadykova K.Zh., Nuskabayeva G.O., Madenbay K.M., Kulakhmetova Kh.B., Aidarbekova D.N., Azizhodzhayeva D.Sh., Kemelbekov K.S., Mussina А.А. The clinical picture of COVID-19 in adult patients of the Turkestan region, depending on comorbid diseases // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 5, pp. 17-26. doi 10.34689/SH.2023.25.5.002Related publications:
IMMUNOLOGICAL CHANGES IN CHILDREN WITH MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH SARS-COV-2
EFFICACY OF THE ANTIVIRAL DRUG ENISAMY IODIDE IN SEVERE ADULT ACUTE RESPIRATORY INFECTIONS IN THE COVID-19 ERA
APPLICATION OF ARTIFICIAL INTELLIGENCE IN COMBATING THE COVID-19 PANDEMIC: CURRENT TRENDS AND PROSPECTS. REVIEW
CONSEQUENCES OF THE CORONAVIRUS INFECTION: THE POST-COVID SYNDROME AND MENTAL MANIFESTATIONS. LITERATURE REVIEW
FEATURES OF THE SICKNESS BEHAVIOR OF ARTERIAL HYPERTENSION AND OBESITY DURING THE PANDEMIC OF COVID-19 CORONAVIRUS. REVIEW