CLINICAL AND SOCIO-DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH MENTAL AND BEHAVIORAL DISORDERS IN THE POST-COVID PERIOD
Introduction: The long-term consequences of the Covid-19 pandemic still remain an urgent problem of our time.
Objective: the study of socio-demographic and clinical characteristics of persons with mental and behavioral disorders in the postcovid period for further improvement of treatment and rehabilitation measures in relation to this category of patients.
Materials and methods: clinical-psychopathological, clinical-dynamic. By the method of continuous selection, 1,670 case histories of patients with mental and behavioral disorders hospitalized in the psychosomatic departments of the RSСE at the «Republican Scientific and Practical Center for Mental Health» of the Ministry of Health of the Republic of Kazakhstan and at the «Mental Health Center in Almaty» for the period from April 2020 were studied. by January 2023: of these, 1,050 in the RСSE at the «Republican Scientific and Practical Center for Mental Health» of the Ministry of Health of the Republic of Kazakhstan, 620 in at the «Mental Health Center in Almaty». For further study, 93 case histories of patients whose mental and behavioral disorders were directly related to a coronavirus infection were selected, which was confirmed by anamnesis, the fact of their hospitalization in infectious hospitals, positive results of PCR tests.
Results: the clinical picture of post-ovoid mental and behavioral disorders in patients who underwent COVID-19 was characterized by polymorphism of psychopathological symptoms and their gender difference: depressive (12-44.4%), insomniac (4-14.8%) and psycho-organic syndrome with cognitive impairment (4-14.8%) were more often detected in male patients, whereas in women, anxiety-phobic (26-39.4%) and asthenic (15-22.72%) syndromes were more often observed.
Conclusion: Among patients with mental and behavioral disorders of the postcovid period, middle-aged females prevailed, while young age is most common among males. Most of the examined patients are married and have a high level of education. The total number of patients was dominated by people who had undergone COVID-19 on an outpatient basis. Depressive and anxiety-phobic syndromes were prevalent in the examined patients. Psychopharmacotherapy of postcovid mental disorders included the administration of antidepressants in combination with neuroleptics and tranquilizers.
Saida Z. Eshimbetova1, Natalia I. Raspopova1, Sapar K. Rakhmensheev1,3 Natalya N. Logacheva1,2, Medina A. Abylgazy1, Gulnafis B. Ramanova1, Zarina G. Gabitova1, Murat R. Azhgireev1, Zarina M. Kurenkeeva1,
Zaure M. Ibraimova1, Yrysbolsyn A. Abdibekov1, Nazerke E. Baqbergenova1
1 NEI «Kazakh-Russian medical university», Department of psychiatry, narcology, Almaty, Republic of Kazakhstan;
2 RSCE «Republican scientific and practical center for mental health», Almaty, Republic of Kazakhstan;
3 Mental health centers in Almaty, Almaty, Republic of Kazakhstan.
1. Мельников К.Н., Повереннова И.Е., Качковский М.А., Кузьмина Т.М., Антонов А.И. Астеновегетативный синдром у перенесших COVID-19 // Саратовский научно-медицинский журнал, 2022. 18(1), С.128-132.
2. Орынбасарова А., Закирова М. Оценка психологического состояния больных, переболевших COVID-19, подтвержденных положительным ПЦР // Научный взгляд в будущее, 2021. (22-01), С. 82-91.
3. Распопова Н.И., Ешимбетова С.З., Джамантаева М.Ш., Сулейменова А.А., Аймакова И.М., Куламкадырова Н.С. Психические нарушения у лиц, перенесших COVID-19, и методы их терапии // Вестник Казахского Национального медицинского университета, 2021. (4), С. 228-234.
4. Aiyegbusi O.L., Hughes S.E., Turner G., Rivera S.C., McMullan C., Chandan J.S., Haroon S., Price G., Davies E.H., Nirantharakumar K., Sapey E., Calvert M.J. TLC Study Group. Symptoms, complications and management of long COVID: a review // JRSocMed. 2021 Sep. 114(9):428-442. doi: 10.1177/01410768211032850. Epub 2021 Jul 15. PMID: 34265229. PMCID: PMC8450986.
5. Al-Aly Z., Bowe B., Xie Y. Long COVID after breakthrough SARS-CoV-2 infection // Nat Med. 2022 Jul. 28(7):1461-1467. doi: 10.1038/s41591-022-01840-0. Epub 2022 May 25. PMID: 35614233; PMCID: PMC9307472.
6. Carod-Artal F.J. Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved // Rev Neurol. 2021 Jun 1. 72(11):384-396. English, Spanish. doi: 10.33588/rn.7211.2021230. PMID: 34042167.
7. Ceban F., Ling S., Lui L.M.W., Lee Y., Gill H., Teopiz K.M., Rodrigues N.B., Subramaniapillai M., Di Vincenzo J.D., Cao B., Lin K., Mansur R.B., Ho R.C., Rosenblat J.D., Miskowiak K.W., Vinberg M., Maletic V., McIntyre R.S. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis // Brain Behav Immun. 2022 Mar;101:93-135. doi: 10.1016/j.bbi.2021.12.020. Epub 2021 Dec 29. PMID: 34973396; PMCID: PMC8715665.
8. Fernández-de-Las-Peñas C., Gómez-Mayordomo V., de-la-Llave-Rincón AI., et al. Anxiety, depression and poor sleep quality as long-term post-COVID sequelae in previously hospitalized patients: A multicenter study // J Infect. 2021 Oct. 83(4):496-522. doi: 10.1016/j.jinf.2021.06.022. Epub 2021 Jun 27. PMID: 34192525, PMCID: PMC8236125.
9. Gautam N., Madathil S., Tahani N., Bolton S., Parekh D., Stockley J., Goyal S., Qureshi H., Yasmin S., Cooper B.G., Short J., Geberhiwot T. Medium-Term Outcomes in Severely to Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection // Clin Infect Dis. 2022 Jan 29;74(2):301-308. doi: 10.1093/cid/ciab341. PMID: 33893486; PMCID: PMC8135551.
10. Hampshire A., Trender W., Chamberlain S.R., Jolly A.E., Grant J.E., Patrick F., Mazibuko N., Williams S.C., Barnby J.M., Hellyer P., Mehta M.A. Cognitive deficits in people who have recovered from COVID-19 // E Clinical Medicine. 2021 Sep. 39:101044. doi: 10.1016/j.eclinm.2021.101044. Epub 2021 Jul 23. PMID: 34316551. PMCID: PMC8298139.
11 Huang C., Huang L., Wang Y., Li X., Ren L., Gu X., Cao B. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study // The Lancet, 2021. 397(10270), 220–232. doi:10.1016/s0140-6736(20)32656-8
12. Huang L., Yao Q., Gu X., Wang Q., Ren L., Wang Y., Cao B. 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study // The Lancet, 2021. 398(10302), 747–758. doi:10.1016/s0140-6736(21)01755-4
13 Kyzar E.J., Purpura L.J., Shah J., Cantos A., Nordvig A.S., Yin M.T. Anxiety, depression, insomnia, and trauma-related symptoms following COVID-19 infection at long-term follow-up // Brain Behav Immun Health. 2021 Oct. 16:100315. doi: 10.1016/j.bbih.2021.100315. Epub 2021 Jul 30. PMID: 34345869, PMCID: PMC8321961.
14. Mazza M.G., De Lorenzo R., Conte C., Poletti S., Vai B., Bollettini I., Melloni E.M.T., Furlan R., Ciceri F., Rovere-Querini P. COVID-19 BioB Outpatient Clinic Study group; Benedetti F. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors // Brain Behav Immun. 2020 Oct;89:594-600. doi: 10.1016/j.bbi.2020.07.037. Epub 2020 Jul 30. PMID: 32738287; PMCID: PMC7390748.
15. Renaud-Charest O., Lui L.M.W., Eskander S., Ceban F., Ho R., Di Vincenzo J.D., Rosenblat J.D., Lee Y., Subramaniapillai M., McIntyre R.S. Onset and frequency of depression in post-COVID-19 syndrome: A systematic review // J Psychiatr Res. 2021 Dec;144:129-137. doi: 10.1016/j.jpsychires.2021.09.054. Epub 2021 Sep 30. PMID: 34619491; PMCID: PMC8482840.
16. Rogers J. P., Chesney E., Oliver D., Pollak T.A., McGuire P., Fusar-Poli P. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic // The Lancet Psychiatry, 2020. 7(7), 611-627.
17. Simonetti A., Bernardi E., Janiri D., Mazza M., Montanari S., Catinari A., Terenzi B., Tosato M., Galluzzo V., Ciciarello F., Landi F., Sani G. Suicide Risk in Post-COVID-19 Syndrome // J Pers Med. 2022 Dec 7;12(12):2019. doi: 10.3390/jpm12122019. PMID: 36556240, PMCID: PMC9785632.
18. Schou T.M., Joca S., Wegener G., Bay-Richter C. Psychiatric and neuropsychiatric sequelae of COVID-19 - A systematic review // Brain Behav Immun. 2021 Oct;97:328-348. doi: 10.1016/j.bbi.2021.07.018. Epub 2021 Jul 30. PMID: 34339806, PMCID: PMC8363196.
19. 2020. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records // Lancet Psychiatry. 2021 May;8(5):416-427. doi: 10.1016/S2215-0366(21)00084-5. Epub 2021 Apr 6. PMID: 33836148; PMCID: PMC8023694.
20. Wang S., Quan L., Chavarro J.E., et al. Associations of Depression, Anxiety, Worry, Perceived Stress, and Loneliness Prior to Infection with Risk of Post–COVID-19 Conditions // JAMA Psychiatry. 2022, 79(11):1081–1091. doi:10.1001/jamapsychiatry.2022.2640
21 Woodward S.F., Bari S., Vike N., Lalvani S., Stetsiv K., Kim B.W., Stefanopoulos L., Maglaveras N., Breiter H., Katsaggelos A.K. Anxiety, Post-COVID-19 Syndrome-Related Depression, and Suicidal Thoughts and Behaviors in COVID-19 Survivors: Cross-sectional Study // JMIR Form Res. 2022 Oct 25;6(10):e36656. doi: 10.2196/36656. PMID: 35763757; PMCID: PMC9604174.
22 Xie Y., Xu E., Al-Aly Z. Risks of mental health outcomes in people with covid-19: cohort study // BMJ. 2022 Feb 16;376:e068993. doi: 10.1136/bmj-2021-068993. PMID: 35172971, PMCID: PMC8847881.
23 Yong S.J. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments // Infect Dis (Lond). 2021 Oct;53(10):737-754. doi: 10.1080/23744235.2021.1924397. Epub 2021 May 22. PMID: 34024217, PMCID: PMC8146298.
24 Zhumanbayeva Zh.M., Кrykpaeva A.S., Serikbayev A.S., Dosbayeva А.М., Amrenova K.Sh., Sharapiyeva A.М., Kudaibergenov R.N., Juszkiewicz K., Zhussupov S.M. Post–COVID syndrome. Review // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 5, pp. 45-51. doi 10.34689/SH.2022.24.5.006
References:
1. Mel'nikov K.N., Poverennova I.E., Kachkovskii M.A., Kuz'mina T.M., Antonov A.I. Astenovegetativnyi sindrom u perenesshikh COVID-19 [Asthenovegetative syndrome in patients with COVID-19]. Saratovskii nauchno-meditsinskii zhurnal [Saratov Journal of Medical Science], 2022. 18(1), pp.128-132. [in Russian]
2. Orynbasarova A., Zakirova M. Otsenka psikhologicheskogo sostoyaniya bol'nykh, perebolevshikh COVID-19, podtverzhdennykh polozhitel'nym PTsR [Assessment of the psychological state of patients who have had COVID-19, confirmed by positive PCR]. Nauchnyi vzglyad v budushchee [A scientific look into the future], 2021. (22-01), pp. 82-91. [in Russian]
3. Raspopova N.I., Eshimbetova S.Z., Dzhamantaeva M.Sh., Suleimenova A.A., Aimakova I.M., Kulamkadyrova N.S. Psikhicheskie narusheniya u lits, perenesshikh COVID-19, i metody ikh terapii [Psychological disorders with COVID-19 methods of their therapy]. Vestnik Kazakhskogo Natsional'nogo meditsinskogo universiteta [Vestnik of the Kazakh National Medical University], 2021. (4), pp. 228-234. [in Russian]
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Eshimbetova S.Z., Raspopova N.I., Rakhmensheev S.K., Logacheva N.N., Abylgazy M.A., Ramanova G.B., Gabitova Z.G., Azhgireev M.R., Kurenkeeva Z.M., Ibraimova Z.M., Abdibekov Y.A., Baqbergenova N.E. Clinical and socio-demographic characteristics of patients with mental and behavioral disorders in the post-covid period // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 6, pp. 152-160. doi 10.34689/SH.2023.25.6.018Related publications:
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