THE RELATIONSHIP BETWEEN BODY MASS INDEX AND BONE MINERAL DENSITY IN THE MIDDLE-AGED AND ELDERLY POPULATION
Actuality. Оsteoporosis (OP) is the most common skeletal metabolic disorder that affects postmenopausal women and includes microarchitectural disorders and decreased bone mineral density (BMD) caused by estrogen deficiency associated with menopause and increasing age. Osteoporosis and overweight are two important aspects of bone health and metabolism. There is a close relationship between body weight and BMD, which is manifested through the influence of various body components such as muscle and fat mass.
The aim to study the relationship between bone mineral density and body mass index in middle-aged and elderly people.
Materials and Methods. The study was conducted from July 2023 to March 2024 in two stages. The study participants were recruited at the Semey Medical University University Hospital in the regional center of the Abai region, Semey city. Basic information for the first stage of the research and questionnaires were collected from 408 respondents. At the second stage, the BMD of the study participants was measured using DXA. Groups with normal and low BMD were formed
Results. The average age in the group with normal BMD was 55.9±7.61 years and in the group with low BMD 58.8±7.6 years. Data analysis between the two groups showed the static significance of BMI (p<0.001) and fractures after minor injuries and falls (p=0.003). To determine the relationship between BMI and BMD, we performed regression analysis, which revealed a number of indicators related to the probability of bone preservation: age (AOR 1.04; 95% CI from 1.01 to 1.07; p <0.006), body mass index (AOR 0.90; 95% CI from 0.86 to 0.94; p <0.000), fracture history (AOR 1.67; 95% CI from 1.05 to 2.66; p <0.030).
Conclusion. Our study has shown that the solution to the problem of reducing BMD in old age should be aimed at controlling risk factors such as body mass index, dieting, and sufficient physical activity. These activities should be initiated in middle age and regardless of the gender of the patients.
Madina Madiyeva1, https://orcid.org/0000-0001-6431-9713
Nurgul Kultumanova1, https://orcid.org/0009-0005-2475-2009
Kairat Almisaev1,https://orcid.org/0009-0005-6519-2319
Aray Mukanova1, https://orcid.org/0000-0001-5603-0207
Daniyar Raissov1, https://orcid.org/0000-0002-3872-1263
Gulzhan Bersimbekova1, https://orcid.org/0000-0002-9416-5054
Gulnur Kanapiyanova1,https://orcid.org/0000-0002-8102-5220
1 NCJSC «Semey Medical University», Semey, Republic of Kazakhstan;
1. Evans A.L., Paggiosi M.A., Eastell R., Walsh J.S. Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood. J Bone Miner Res. 2015 May.30(5):920-8. doi: 10.1002/jbmr.2407.
2. GargM.K., KharbS.Dual energy X-ray absorptiometry: Pitfalls in measurement and interpretation of bone mineral density. Indian J. Endocrinol. Metab. 2013, 17, 203–210.https://doi.org/10.4103/2230-8210.109659
3. Gkastaris K., Goulis D.G., Potoupnis M., Anastasilakis A.D., Kapetanos G. Obesity, osteoporosis and bone metabolism. J Musculoskelet Neuronal Interact. 2020 Sep 1. 20(3):372-381
4. InternationalSocietyforClinicalDensitometry.Availableonline:https://iscd.org/official-positions-2023. (accessedon15April2024).
5. Jia L., Cheng M. Correlation analysis between risk factors, BMD and serum osteocalcin, CatheK, PINP, β-crosslaps, TRAP, lipid metabolism and BMI in 128 patients with postmenopausal osteoporotic fractures. Eur Rev Med Pharmacol Sci. 2022 Nov. 26(21):7955-7959. doi: 10.26355/eurrev_202211_30147.
6. Kanis J.A., Cooper C., Rizzoli R., Reginster J.Y. Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2019 Jan. 30(1):3-44. doi: 10.1007/s00198-018-4704-5.
7. Li Y. Association between obesity and bone mineral density in middle-aged adults. J Orthop Surg Res. 2022 May 14. 17(1):268. doi: 10.1186/s13018-022-03161-x
8. Madeira E., Mafort T.T., Madeira M., Guedes E.P., Moreira R.O., de Mendonça L.M., Lima I.C., de Pinho P.R., Lopes A.J., Farias M.L. Lean mass as a predictor of bone density and microarchitecture in adult obese individuals with metabolic syndrome. Bone. 2014 Feb. 59:89-92. doi: 10.1016/j.bone.2013.11.004.
9. Rinonapoli G., Ruggiero C., Meccariello L., Bisaccia M., Ceccarini P., Caraffa A. Osteoporosis in Men: A Review of an Underestimated Bone Condition. Int J Mol Sci. 2021. 22(4):2105. doi: 10.3390/ijms22042105.
10. Rizzoli R. Postmenopausal osteoporosis: Assessment and management. Best Pract Res Clin Endocrinol Metab 2018. 32:739–75.
11. Saarelainen J., Kiviniemi V., Kröger H., Tuppurainen M., Niskanen L., Jurvelin J., Honkanen R. Body mass index and bone loss among postmenopausal women: the 10-year follow-up of the OSTPRE cohort. J Bone Miner Metab. 2012 Mar. 30(2):208-16. doi: 10.1007/s00774-011-0305-5.
12. United Nations.World Population Prospects: The 2017 Revision, World Population 2017 Wallchart; Department of Economic and Social Affairs: New York, USA, 2017.
13. Wang L., Yu W., Yin X., et al. Prevalence of Osteoporosis and Fracture in China: The China Osteoporosis Prevalence Study. JAMA Netw Open. 2021. 4(8):e2121106.doi:10.1001/jamanetworkopen.2021.21106
14. Wang X., Zhang C., Zhao G., Yang K., Tao L. Obesity and lipid metabolism in the development of osteoporosis (Review). Int J Mol Med. 2024 Jul. 54(1):61. doi: 10.3892/ijmm.2024.5385. Epub 2024 May 31.
15. Xie R., Huang X., Zhang Y., Liu Q., Liu M. High Low-Density Lipoprotein Cholesterol Levels are Associated with Osteoporosis Among Adults 20-59 Years of Age. Int J Gen Med. 2022 Feb 28. 15:2261-2270. doi: 10.2147/IJGM.S353531.
Number of Views: 8
Category of articles:
Original article
Bibliography link
Madiyeva M., Kultumanova N., Almisaev K., Mukanova A., Raissov D., Bersimbekova G., Kanapiyanova G. The relationship between body mass index and bone mineral density in the middle-aged and elderly population // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (6), pp. 88-93. doi 10.34689/SH.2024.26.6.011Related publications:
THE RELATIONSHIP BETWEEN BODY MASS INDEX AND BONE MINERAL DENSITY IN THE MIDDLE-AGED AND ELDERLY POPULATION
CLINICAL, MORPHOLOGICAL AND MORPHOMETRIC ASSESSMENT OF GRANULOMATOUS INFLAMMATION IN SARCOIDOSIS AND PULMONARY TUBERCULOSIS
DRUG-INDUCED LIVER INJURY IN HIV-INFECTED PATIENTS WITH ACTIVE TUBERCULOSIS: COMPARATIVE LABORATORY CHARACTERIZATION
RESULTS OF THE IMPLEMENTATION OF THE DISEASE MANAGEMENT PROGRAM ON CHRONIC HEART FAILURE IN THE REPUBLIC OF KAZAKHSTAN
AVOIDABLE DEATHS FROM ONCOLOGY DISEASE IN AKTOBE REGION