PATHOGENETIC ASSESSMENT OF CLINICAL AND INSTRUMENTAL PARAMETERS OF THE LUNGS IN PATIENTS WITH DIABETES MELLITUS
Background: For the past two decades, many studies have investigated how diabetes mellitus (DM) affects the bronchopulmonary system, but the results have been inconsistent. Diabetes mellitus leads to metabolic disorders and lack of oxygen. And thus causes problems in the lungs and their vessels. One of the common diseases is increased ventilation of the lungs.
Aim of the study is to identify the features and characteristics of the effect of diabetes mellitus and its concomitant pathologies on the morphofunctional state of the respiratory system.
Materials and methods. The sample size was 395 people. A One Touch® glucose meter and a DCA-2000 MT analyzer were used for laboratory and diagnostic assessment of the patients' condition. C-peptide, hormone levels, and insulin resistance indices (Caro and HOMA-IR) were determined using standard laboratory techniques. Instrumental examinations included chest X-rays, computer spirometry, and bronchoscopy.
Results. Lung function disorders were found in the study sample of patients: from bronchial obstruction in type 1 diabetes to restrictive and perfusion disorders in combination with type 2 diabetes with coronary heart disease and obesity.
Conclusion. As a result of the study, it was found that diabetes mellitus is associated with various disorders of respiratory function, including restrictive and obstructive changes, as well as morphological changes in the lung tissue and vascular system. Ultrasound revealed a complex of destructive and inflammatory changes in the lungs.
Zhautikova Saule - Professor of the Department of Physiology of NJSC «Karaganda Medical University», Gogol str. 40, Karaganda 100000, Kazakhstan. https://orcid.org/0009-0000-5712-7369; е-mail: zhautikova@qmu.kz; Cell phone +7 701 299 34 07
Urazalina Nailya - Candidate of Medical Sciences, Associate Professor of the Department of physiological disciplines named after honored scientist of the republic of Kazakhstan, professor T.A. Nazarova, NJSC "Semey Medical University", Semey, Kazakhstan; phone: 8 777 907 55 89, е-mail: hakim_15@mail.ru, https://orcid.org/0000-0003-0200-1763,
Bakaramova Gulnur - Assistant Professor of the Department of Physiology of NJSC «Karaganda Medical University», Gogol str. 40, Karaganda 100000, Kazakhstan. https://orcid.org/0009-0001-1169-9596; е-mail: Bakaramova@qmu.kz; Cell phone +7 778 675 33 64
Tolubayeva Diana - Doctor PhD “Medical Center Hospital of the President affairs Administration of the Republic of Kazakhstan” Astana, https://orcid.org/0000-0003-3119-7814; е-mail: dianajianna@gmail.com; Cell phone +7 701 299 34 06.
Tanysheva Gulyash – Candidate of Medical Sciences, Head of the Department of Obstetrics and Gynecology, NCJSC «Semey Medical University», phone 8(777)153-53-57, email gulyash1965@mail.ru, https://orcid.org/0000-0001-9531-5950, Semey, Kazakhstan;
Orazalina Ainash – Candidate of Biological Sciences, Associate Professor, Head of the Department of Molecular Biology and Medical Genetics named after Academician of the National Academy of Sciences of the Republic of Kazakhstan T.K. Raisov, NJSC «Semey Medical University», phone; +7-777-235-47-72; e-mail: ainash.orazalina@smu.edu.kz; https://orcid.org/0000- 0003-4594-0138; Semey, Kazakhstan.
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Zhautikova S.B., Urazalina N.M., Bakaramova G.A., Tolubayeva D.B., Tanysheva G.А., Orazalina A.S. Pathogenetic assessment of clinical and instrumental parameters of the lungs in patients with diabetes mellitus // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 31-38. doi 10.34689/SH.2025.27.2.004Related publications:
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