THE RELATIONSHIP BETWEEN ACUTE CORONARY SYNDROME AND CARBOHYDRATE METABOLISM DISORDERS
Introduction. The main cause of people’s death, according to WHO, remains cardiovascular diseases (CVD). The majority of deaths (85%) occur as a result of myocardial infarction (MI) and stroke [16]. The prevalence of CVD in DM2 (type 2 diabetes mellitus) according to the CAPTURE study is 31.8% [17]. In 54.3% of cases the causes of death in DM2 are CVD [5]. The high frequency of acute coronary syndrome (ACS) in DM2 (22-43%) [1,9,11,15] draws attention to itself.
Objective: to evaluate the relationship of newly identified disorders of carbohydrate metabolism (DCM) and acute coronary syndrome.
Materials and methods: A quantitative, cross-sectional study of 200 patients with acute coronary syndrome without a history of DCM was conducted. The main group consisted of patients with newly identified DCM (126 patients), the control group included patients without them (74 patients). Statistical analysis was performed using the IBM SPSS Statistics 23 statistical program. Methods of parametric and nonparametric statistics were used. The differences between the groups were considered statistically significant at p<0.05.
Results: The main end result of our research was to identify the relationship between NUO and ACS. One of the important results of the study was to identify the prevalence of DCM in patients with ACS, as well as the structure of ACS depending on the state of carbohydrate metabolism.
Conclusions: Disorders of carbohydrate metabolism were detected in 63% of the examined patients. DCM were more common in patients with MI compared to patients with unstable angina.
The largest number of patients with newly diagnosed DM2 was in the group of patients with ST segment elevation. The increased level of HbA1c in all patients with DCM in ACS indicates the previous nature of the detected disorders and the probable association of the formation of ACS with DCM.
Svetlana U. Kazaryan1, https://orcid.org/0000-0002-8511-2567
Rimma B. Bazarbekova2, https://orcid.org/0000-0002-0470-7594
Ainur K. Dosanova2, https://orcid.org/0000-0002-0565-9651
Gulnara A. Dzhunusbekova3, https://orcid.org/0000-0001-7452-5625
Karashash S. Absatarova4, https://orcid.org/0000-0003-2739-3468
Aigul O. Doskulova5
1 KMU "Higher School of Public Health", Almaty, Republic of Kazakhstan;
2 NGEI "Kazakh-Russian Medical University", Almaty, Republic of Kazakhstan;
3 NJSC "Kazakh National Medical University named after S.D. Asfendiyarov",
Almaty, Republic of Kazakhstan;
4 NJSC "Al-Farabi Kazakh National University", Almaty, Republic of Kazakhstan;
5 City clinical Hospital No. 7, Almaty, Republic of Kazakhstan.
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Kazaryan S.U., Bazarbekova R.B., Dosanova A.K., Dzhunusbekova G.A., Absatarova K.S., Doskulova A.O. The relationship between acute coronary syndrome and carbohydrate metabolism disorders // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 6, pp. 38-45. DOI 10.34689/SH.2023.25.6.005Related publications:
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