Online ISSN: 3007-0244,
Print ISSN:  2410-4280
IMMUNOLOGICAL CHANGES IN CHILDREN WITH MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH SARS-COV-2
Introduction. SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) is characterized by signs and symptoms reflecting intense immune activation with increased production of cytokines. Аim. The aim of our study was to study changes in the immune response in children with MVS associated with SARS-CoV-2. Methods. The study included 35 children with MIS-C associated with SARS-CoV-2, the control group consisted of 15 healthy children who had COVID-19 and did not develop MIS-C. The state of the immune response in all patients was assessed by the method of immunophenotyping of peripheral blood. Results. Children with MIS-C associated with SARS-CoV-2 had CD3+ T-cell lymphopenia, a decrease in NK cells, a decrease in the expression of the apoptosis marker CD95, and an increase in the expression of the activation marker CD25. The change in the humoral immune response was manifested as an increase in the relative number of B-lymphocytes and an increase in the expression of the B-cell activation marker CD3-HLA-DR+. Conclusions. Children with MIS-C associated with SARS-CoV-2 have profound immune dysregulation, as evidenced by our data.
Indira S. Jaxybayeva1,2 https://orcid.org/0000-0001-7456-6638 Riza Z. Boranbayeva1, https://orcid.org/0000-0002-7195-5926 Minira G. Bulegenova1, https://orcid.org/0000-0002-1625-0173 Aizhan A. Tolganbayeva2, https://orcid.org/0009-0005-5300-8238 Natalya T. Urazaliyeva1, https://orcid.org/0000-0002-1625-0173 Elena A. Kustova1, https://orcid.org/0000-0003-4922-1739 Valentin I. Gerein3, https://orcid.org/0000-0001-6259-5773 1 Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Republic of Kazakhstan; 2 Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan; 3 Clinic of Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
1. Beckmann N.D. et al. Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children // Nature communications. 2021. Т. 12. №. 1. С. 1-15. 2. Bellesi S. et al. Increased CD95 (Fas) and PD‐1 expression in peripheral blood T lymphocytes in COVID‐19 patients // British journal of haematology. 2020. Т. 191. №. 2. С. 207-211. 3. Bukulmez H. Current understanding of multisystem inflammatory syndrome (MIS-C) following COVID-19 and its distinction from Kawasaki disease //Current Rheumatology Reports. 2021. Т.23. №. 8. С. 1-11. 4. Carter M.J. et al. Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection //Nature medicine. – 2020. Т. 26. №. 11. С. 1701-1707. 5. Cencioni M.T. The immune regulation of PD-1/PDL-1 axis, a potential biomarker in multiple sclerosis // Neuroimmunology and Neuroinflammation. 2020. Т. 7. №. 3. С. 277-290. 6. Consiglio C.R. et al. The immunology of multisystem inflammatory syndrome in children with COVID-19 // Cell. 2020. Т. 183. №4. С. 968-981. e7. 7. Cook K.D., Whitmire J.K. The depletion of NK cells prevents T cell exhaustion to efficiently control disseminating virus infection // The Journal of Immunology. 2013. Т. 190. №. 2. С. 641-649. 8. Esteve-Sole A. et al. Similarities and differences between the immunopathogenesis of COVID-19–related pediatric multisystem inflammatory syndrome and Kawasaki disease // The Journal of clinical investigation. 2021. Т.131. №6. С. e144554. 9. Feldstein L.R. et al. Multisystem inflammatory syndrome in US children and adolescents // New England Journal of Medicine. 2020. Т. 383. №4. С. 334-346. 10. Jiang T.T. et al. Programmed death-1 culls peripheral accumulation of high-affinity autoreactive CD4 T cells to protect against autoimmunity // Cell reports. 2016. Т. 17. №7. С. 1783-1794. 11. Lee P.Y. et al. Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children // The Journal of clinical investigation. 2020. Т. 130. №. 11. С. 5942-5950. 12. Moreews M. et al. Polyclonal expansion of TCR Vb 21.3+ CD4+ and CD8+ T cells is a hallmark of multisystem inflammatory syndrome in children // Science immunology. 2021. Т. 6. №.59. С. eabh1516. 13. Reddy M. et al. Comparative analysis of lymphocyte activation marker expression and cytokine secretion profile in stimulated human peripheral blood mononuclear cell cultures: an in vitro model to monitor cellular immune function // Journal of immunological methods. 2004. Т. 293. №. 1-2. С. 127-142. 14. Ross S.H., Cantrell D.A. Signaling and function of interleukin-2 in T lymphocytes // Annual review of immunology. 2018. Т.36. С.411. 15. Syrimi E., Fennell E., Richter A., et al. The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery // Iscience. 2021. Т. 24. №. 11. С. 103215. 16. Waggoner S.N. et al. Natural killer cells act as rheostats modulating antiviral T cells // Nature. 2012. Т. 481. №. 7381. – С. 394-398.
Number of Views: 99


Category of articles: COVID-19 - Topical Subject

Bibliography link

Jaxybayeva I.S., Boranbayeva R.Z., Bulegenova M.G., Tolganbayeva A.A., Urazaliyeva N.T., Kustova E.A., Gerein V.I. Immunological changes in children with multisystem inflammatory syndrome associated with SARS-COV-2 // Nauka i Zdravookhranenie [Science & Healthcare]. 2024, (Vol.26) 1, pp. 132-139. doi 10.34689/SH.2024.26.1.017

Авторизируйтесь для отправки комментариев