IMMUNOLOGICAL AND CYTOGENETIC STATUS RELATIVELY HEALTHY RESIDENTS OF ALMATY CITY AND ALMATY REGION IN DYNAMICS
Introduction. At present, many countries are developing and implementing in practice the principles of research and preventive medicine based on the integral evaluation of the immune system and genetic features of the population. The study of cytogenetic and immunological status is one of the well-known and informative methods for the indication of health and environmental effects on humans.
Objective: study of the cytogenetic and immunological status of residents of Almaty city and Almaty region according to the criteria of chromosome aberrations formation in lymphocytes of peripheral blood and the content of immunoglobulins in plasma in almost healthy people in the dynamics for the last 15 years.
Materials and methods. In the comparative dynamics during 15 years biochemical and cytogenetic study of the almost healthy people aged 35 to 60 years living in Almaty and Almaty region has been conducted. They determined the level of immunoglobulins in the blood serum, the frequency and spectrum of chromosome aberrations in lymphocytes of peripheral blood.
Results. Differences of the contents of immunoglobulins in the plasma of practically healthy people of urban and rural populations of Almaty region have been established. The correlation of their content in the plasma of a number of factors - the location of residence, the ecological situation of the area, age. The data obtained indicate that the analysis of immunoglobulins and their interpretation will be more informative for a more accurate diagnosis and prediction of morbidity. The cytogenetic study of the residents of Almaty city showed that the frequency of chromosome aberrations among the residents of Almaty city has reliably increased for the last 15 years and its level is higher than in people living in the countryside. The correlation of these indexes was revealed. The necessity of constant monitoring of the immune and cytogenetic status of the population under the increasing anthropogenic load is shown. It has been argued whether it is appropriate to compare the urban and rural population groups under research with the urban ones and to choose control groups 13 for the ecological genetic and immunologic studies.
Conclusions. The last fifteen years have shown negative dynamics of cytogenetic and immunologic indexes in essentially healthy individuals, which was likely caused by the previous coronavirus pandemic as well as the deterioration of the ecological condition.
Keywords: immunity, immunoglobulins, chromosome aberrations, plasma, lymphocytes, ecology.
Number of Views: 399
Bibliography link
Cherednichenko O.G., Demchenko G.A., Kapysheva U.N., Bakhtiyarova Sh.K., Pilyugina A.L., Kozhaniyazova U.N., Zhaksymov B.I., Koibasova L.U. Immunological and cytogenetic status relatively healthy residents of Almaty city and Almaty region in dynamics // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (3), pp. 40-53. doi 10.34689/SH.2024.26.3.005Related publications:
GENETIC VARIANTS IN LIPID-ASSOCIATED GENES IN THE KAZAKHSTANI COHORT WITH ATHEROSCLEROSIS AND HYPERTRIGLYCERIDEMIA
CLONAL HEMATOPOIESIS WITH INDETERMINATE POTENTIAL IN TET2 AND DNMT3A AMONG KAZAKHSTANI INDIVIDUALS WITH ATHEROSCLEROTIC DISEASE
PRELIMINARY ANALYSIS AND ASSESSMENT OF THE HEALTH STATUS OF THE DESCENDANTS OF PERSONS EXPOSED TO RADIATION, LIVING IN THE BESKARAGAI DISTRICT OF THE ABAY REGION
PRELIMINARY ANALYSIS OF THE HEALTH STATUS AND RADIATION DOSES OF RESIDENTS OF THE ABAY DISTRICT OF THE ABAY REGION, WHO ARE DESCENDANTS OF PERSONS EXPOSED TO RADIATION DUE TO NUCLEAR WEAPONS TESTS
TRENDS AND DISPARITIES IN CANCER MORBIDITY IN KAZAKHSTAN: A REGIONAL AND AGE-BASED ANALYSIS FOR 2014-2024