PROGNOSTIC SIGNIFICANCE OF GENETIC TUMOR MARKERS IN THYROID NEOPLASMS: LITERATURE REVIEW
Background. This review examines recent advances in the identification of molecular markers using next-generation sequencing and microarrays. The potential for using these tumor markers to differentiate the most common sporadic forms of thyroid cancer is presented and compared. Public databases with datasets obtained from high-throughput experiments are a valuable source of information that helps tumor marker research in general, including the identification of molecular signatures of thyroid tumors.
The aim of this review is to analyze well-established tests with a special emphasis on the effective role of new potential thyroid tumor markers based on modern data on the molecular genetic mechanisms involved in the tumor process.
Search strategy. To conduct the study, articles in the public domain were analyzed using the following databases and specialized search engines for scientific publications: PubMed, Web of Science, Scopus, Google Scholar, Cochrane Library. Inclusion criteria: publications with a high level of evidence (level A and B), including meta-analyses, systematic reviews and cross-sectional studies. Short reports and advertising articles were excluded.
Results and conclusions. The literature review is devoted to the problem of prognostic significance of genetic tumor markers of thyroid gland tumors. Various types of tumor markers of thyroid gland tumors are presented, including tumor markers of benign neoplasms. The significance of tumor markers of thyroid gland tumors is substantiated.
Number of Views: 3109
Bibliography link
Espenbetova M.Zh., Bidakhmetova A.M., Krykpaeva A.S., Uasheva L.B., Syzdykbaev M.K., Baimukhanova A.A., Baurzhan A.B. Prognostic Significance of Genetic Tumor Markers in Thyroid Neoplasms: Literature Review // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (5), pp. 204-212. doi 10.34689/SH.2024.26.5.024Related publications:
GENETIC VARIANTS IN LIPID-ASSOCIATED GENES IN THE KAZAKHSTANI COHORT WITH ATHEROSCLEROSIS AND HYPERTRIGLYCERIDEMIA
CLONAL HEMATOPOIESIS WITH INDETERMINATE POTENTIAL IN TET2 AND DNMT3A AMONG KAZAKHSTANI INDIVIDUALS WITH ATHEROSCLEROTIC DISEASE
PRELIMINARY ANALYSIS AND ASSESSMENT OF THE HEALTH STATUS OF THE DESCENDANTS OF PERSONS EXPOSED TO RADIATION, LIVING IN THE BESKARAGAI DISTRICT OF THE ABAY REGION
PRELIMINARY ANALYSIS OF THE HEALTH STATUS AND RADIATION DOSES OF RESIDENTS OF THE ABAY DISTRICT OF THE ABAY REGION, WHO ARE DESCENDANTS OF PERSONS EXPOSED TO RADIATION DUE TO NUCLEAR WEAPONS TESTS
TRENDS AND DISPARITIES IN CANCER MORBIDITY IN KAZAKHSTAN: A REGIONAL AND AGE-BASED ANALYSIS FOR 2014-2024