A CASE OF AUTOIMMUNE COMPLICATIONS FOLLOWING COVID-19 VACCINATION WITH SINOVAC-CORONAVAC (CHINA)
During the COVID-19 pandemic, vaccination in the Republic of Kazakhstan utilized the vaccine SinoVac-CoronaVac (China), which contains a chemically inactivated form of the SARS-CoV-2 virus and an adjuvant to stimulate immunity. A retrospective analysis was conducted on the medical history and observation of a patient, T., born in 1989, who developed overlap syndrome, rheumatoid arthritis, and systemic lupus erythematosus (SLE) after receiving the SinoVac-CoronaVac vaccine.
Blood analysis revealed leukopenia (2.8 × 10⁹), thrombocytopenia (104 units/µL), hypochromic anemia (hemoglobin 87 g/L), increased ESR, elevated rheumatoid factor (13.9), increased CRP (70.4), and elevated anti-streptolysin O (218 IU/mL). Antibodies to nuclear antigens (ANA) were also detected (32 units). The patient was treated with hormones, non-steroidal anti-inflammatory drugs, and rituximab.
This case suggests that COVID-19 vaccination with the SinoVac-CoronaVac vaccine activated the immune system and acted as a trigger for the development of autoimmune overlap syndrome. Recognizing the possibility of autoimmune complications enables better patient monitoring and care post-vaccination.
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Nurgaliyeva B., Akzhalova Yu., Khaidarov S., Moldakaryzova A. A Case of Autoimmune Complications Following COVID-19 Vaccination with SinoVac-CoronaVac (China) // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (6), pp. 230-233. doi 10.34689/SH.2024.26.6.026Related publications:
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