THE ROLE OF ESSENTIAL AND TOXIC TRACE ELEMENTS IN THE DEVELOPMENT OF KIDNEY STONE DISEASE. LITERATURE REVIEW
Relevance. A literature review focused on the impact of essential and toxic trace elements on the development of kidney stone disease. Special attention is given to the relationship between trace element imbalance, mineral metabolism disorders, oxidative stress, and inflammatory processes, which play a key role in the mechanisms of stone formation.
Search Strategy: A systematic search of scientific publications was conducted in the PubMed, Scopus, Web of Science, Google Scholar, and Science Direct databases. The search period covered 10 years. A total of 60 articles, containing data on the role of essential and toxic trace elements in the pathogenesis of kidney stone disease, were included in the analysis.
Results: Data on the impact of essential trace elements (calcium, magnesium, zinc, selenium) and toxic metals (lead, cadmium, mercury, arsenic) on the stone formation processes are presented. It was found that trace element imbalance may contribute to disturbances in mineral metabolism, the development of oxidative stress, and inflammatory reactions, which play a key role in the pathogenesis of kidney stone disease. The findings confirm the significant involvement of trace elements in the mechanisms of urolith formation.
Conclusion: Monitoring the levels of trace elements in the body and reducing exposure to toxic metals may contribute to the prevention of kidney stone disease. Further research is needed to develop effective prevention and treatment strategies, focusing on studying the mechanisms through which trace elements influence stone formation processes.
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Kanatbekova A.K., Kozykenova Zh.U., Apsalikov B.A., Akkaliyev M.N., Shagiyeva D.Sh., Mukasheva G.D., Terlikbaeva G.A., Buleukhanova R.T., Yessenbayeva А.А., Massabayeva M.R. The role of essential and toxic trace elements in the development of kidney stone disease. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 179-187. doi 10.34689/SH.2024.27.2.020Related publications:
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