EVALUATION OF THE EFFECTIVENESS OF MOLECULAR ALLERGY DIAGNOSTIC METHODS IN THE PERSONALIZED MANAGEMENT OF PATIENTS WITH ALLERGIC RHINITIS
Introduction: Allergic rhinitis (AR) is a common IgE-mediated condition that significantly reduces quality of life. Conventional diagnostic methods do not always allow for the accurate identification of causative allergens, especially in cases of polysensitization.
Objective: A comparative evaluation of the effectiveness of two molecular allergy diagnostic methods—ImmunoCAP and immunochemiluminescent assay (ICLA)—in patients with allergic rhinitis.
Methods: A retrospective study involving 60 patients with confirmed AR was conducted. Sensitivity, specificity, predictive values, and overall diagnostic performance of the methods were analyzed. Pearson’s chi-squared test, ROC analysis, and calculation of AUC were applied.
Results: ImmunoCAP demonstrated a sensitivity of 87.8% and an AUC of 0.88. ICLA showed higher specificity (61.3%) and an AUC of 0.79. PPV was comparable (66.7% vs. 65.7%), whereas NPV was higher for ICLA (76.0% vs. 16.7%). The differences between the methods were statistically significant (p = 0.001).
Conclusions: Both methods are valuable tools in the diagnosis of AR. ImmunoCAP is preferable for the initial detection of sensitization, while ICLA is more suitable for confirming clinically relevant allergy and minimizing false-positive results.
Number of Views: 333
Category of articles:
Original article
Bibliography link
Valiyeva S.R., Glushkova N.E., Buribayeva Zh.K., Izekenova A.K. Evaluation of the effectiveness of molecular allergy diagnostic methods in the personalized management of patients with allergic rhinitis // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (3), pp. 151-156. doi 10.34689/SH.2025.27.3.017Related publications:
REPROGRAMMING EXPERIENCE OF BLOOD MONONUCLEAR CELLS INTO INDUCED PLURIPOTENT STEM CELLS (IPSCS) IN A PATIENT WITH CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
CREATION OF THE PREGNANCY MICE MODEL TO STUDY THE EFFECT OF GLP-1/GIP AGONISTS
SATISFACTION WITH THE QUALITY OF PRIMARY CARE FOR PATIENTS WITH HYPERTENSION
EPIDEMIOLOGY, RESOURCE DISTRIBUTION, AND MANAGEMENT CHALLENGES OF CHRONIC HEART FAILURE IN KAZAKHSTAN: A NATIONAL RETROSPECTIVE ANALYSIS
PREVALENCE OF POLYMORPHISMS IN WARFARIN METABOLISM-RELATED GENES AMONG THE KAZAKH POPULATION